Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zuzana Nichtová"'
Autor:
Abhishek Aich, Angela Boshnakovska, Steffen Witte, Tanja Gall, Kerstin Unthan-Fechner, Roya Yousefi, Arpita Chowdhury, Drishan Dahal, Aditi Methi, Svenja Kaufmann, Ivan Silbern, Jan Prochazka, Zuzana Nichtova, Marcela Palkova, Miles Raishbrook, Gizela Koubkova, Radislav Sedlacek, Simon E. Tröder, Branko Zevnik, Dietmar Riedel, Susann Michanski, Wiebke Möbius, Philipp Ströbel, Christian Lüchtenborg, Patrick Giavalisco, Henning Urlaub, Andre Fischer, Britta Brügger, Stefan Jakobs, Peter Rehling
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since c
Externí odkaz:
https://doaj.org/article/fbb1f03201784bd1bc12298332352d79
Autor:
Arpita Chowdhury, Angela Boshnakovska, Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon, Ivan Silbern, Christian Lüchtenborg, Lukas Cyganek, Jan Prochazka, Radislav Sedlacek, Jiri Lindovsky, Dominic Wachs, Zuzana Nichtova, Dagmar Zudova, Gizela Koubkova, André Fischer, Henning Urlaub, Britta Brügger, Dörthe M Katschinski, Jan Dudek, Peter Rehling
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-21 (2023)
Abstract Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS) is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase tafazzin. Altered cardiolipin remodeling affects mitochondri
Externí odkaz:
https://doaj.org/article/d06b0aeb0b084c3dae36b33896fa43c5
Autor:
Máté Katona, Ádám Bartók, Zuzana Nichtova, György Csordás, Elena Berezhnaya, David Weaver, Arijita Ghosh, Péter Várnai, David I. Yule, György Hajnóczky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The formation and dissolution of ER-Mitochondria contacts is unclear. Here, authors show that the IP3 receptor traffics in and out of the contacts and, when trapped, improves calcium signaling to stimulate energy metabolism.
Externí odkaz:
https://doaj.org/article/89e82e0994884eee859938e0f2c594f8
Autor:
César Vásquez-Trincado, Julia Dunn, Ji In Han, Briyanna Hymms, Jaclyn Tamaroff, Monika Patel, Sara Nguyen, Anna Dedio, Kristin Wade, Chinazo Enigwe, Zuzana Nichtova, David R. Lynch, Gyorgy Csordas, Shana E. McCormack, Erin L. Seifert
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Friedreich’s ataxia (FRDA) is an inherited disorder caused by reduced levels of frataxin (FXN), which is required for iron-sulfur cluster biogenesis. Neurological and cardiac comorbidities are prominent and have been a major focus of study. Skeleta
Externí odkaz:
https://doaj.org/article/d8ce409b580d48b49f4391b0d76d2a4c
Autor:
Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural
Externí odkaz:
https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
Autor:
Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D Byrne, Zuzana Nichtova, Ioana Stefanescu, Fnu Pardeep‐Kumar, Sushil Tripathi, Eric Londin, Pascale Saugier‐Veber, Belinda Willard, Mathew Thakur, Stephen Pickup, Hiroshi Ishikawa, Horst Schroten, Richard Smeyne, Arie Horowitz
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ. Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality. We show
Externí odkaz:
https://doaj.org/article/9e7dfd6574c64708bffe246dee632cbb
Autor:
Sergio De La Fuente, Jonathan P. Lambert, Zuzana Nichtova, Celia Fernandez Sanz, John W. Elrod, Shey-Shing Sheu, György Csordás
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3099-3107.e4 (2018)
Summary: Mitochondrial Ca2+ elevations enhance ATP production, but uptake must be balanced by efflux to avoid overload. Uptake is mediated by the mitochondrial Ca2+ uniporter channel complex (MCUC), and extrusion is controlled largely by the Na+/Ca2+
Externí odkaz:
https://doaj.org/article/84a912c7503a491c8bfc9d16084ca19c
Autor:
Zuzana Nichtová, Celia Fernandez-Sanz, Sergio De La Fuente, Yuexing Yuan, Stephen Hurst, Sebastian Lanvermann, Hui-Ying Tsai, David Weaver, Ariele Baggett, Christopher Thompson, Cedric Bouchet-Marquis, Péter Várnai, Erin L. Seifert, Gerald W. Dorn, Shey-Shing Sheu, György Csordás
Publikováno v:
Circulation Research. 132
Background: Cardiac contractile function requires high energy from mitochondria, and Ca 2+ from the sarcoplasmic reticulum (SR). Via local Ca 2+ transfer at close mitochondria-SR contacts, cardiac excitation feedforward regulates mitochondrial ATP pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ac62ba01fb0bbbb448770307a52e7d
https://doi.org/10.1161/circresaha.122.321833
https://doi.org/10.1161/circresaha.122.321833
Autor:
Marta Novotová, Alexandra Zahradníková, Zuzana Nichtová, Radoslav Kováč, Eva Kráľová, Tatiana Stankovičová, Ivan Zahradník
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Cardiac excitation-contraction coupling relies on dyads, the intracellular calcium synapses of cardiac myocytes, where the plasma membrane contacts sarcoplasmic reticulum and where electrical excitation triggers calcium release. The morphology of dya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ee242e4da1a0b7d4e9141c01c29137
http://europepmc.org/articles/PMC7229197
http://europepmc.org/articles/PMC7229197
Autor:
Pamela V, Martino Adami, Zuzana, Nichtová, David B, Weaver, Adam, Bartok, Thomas, Wisniewski, Drew R, Jones, Sonia, Do Carmo, Eduardo M, Castaño, A Claudio, Cuello, György, Hajnóczky, Laura, Morelli
Publikováno v:
J Cell Sci
The use of fixed fibroblasts from familial and sporadic Alzheimer's disease patients has previously indicated an upregulation of mitochondria–ER contacts (MERCs) as a hallmark of Alzheimer's disease. Despite its potential significance, the relevanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05d7f3abe94391026f47f9b3e6b40755
https://pubmed.ncbi.nlm.nih.gov/31515277
https://pubmed.ncbi.nlm.nih.gov/31515277