Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zuzana Nahacka"'
Autor:
Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova, Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova, Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K. Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini, T. M. Iverson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Complex II (CII) activity controls phenomena that require crosstalk between metabolism and signaling, including neurodegeneration, cancer metabolism, immune activation, and ischemia-reperfusion injury. CII activity can be regulated at the le
Externí odkaz:
https://doaj.org/article/a63f5096183a4241a866d4154beb8b16
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mitochondria are organelles essential for tumor cell proliferation and metastasis. Although their main cellular function, generation of energy in the form of ATP is dispensable for cancer cells, their capability to drive their adaptation to stress or
Externí odkaz:
https://doaj.org/article/1235d0dc2976444aa89950ddcd6085cb
Autor:
Verena Henrichs, Lenka Grycova, Cyril Barinka, Zuzana Nahacka, Jiri Neuzil, Stefan Diez, Jakub Rohlena, Marcus Braun, Zdenek Lansky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates
Externí odkaz:
https://doaj.org/article/100a9a30842b49bfb6e6362c1f4832c1
Autor:
Pavel Klener, Marek Trneny, Eva Fronkova, Adela Berkova, Petra Vockova, Mariana Pacheco-Blanco, Kristina Forsterova, Karel Helman, Eva Pokorna, Diana Tuskova, Zuzana Zemanova, Karla Svobodova, Jan Soukup, Ondrej Havranek, Magdalena Klanova, Michael Svaton, Jana Karolova, Zuzana Nahacka, Ladislav Andera, Dana Prukova
Purpose:Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f5c886ce44042199a0881ea8008748
https://doi.org/10.1158/1078-0432.c.6528017
https://doi.org/10.1158/1078-0432.c.6528017
Autor:
Pavel Klener, Marek Trneny, Eva Fronkova, Adela Berkova, Petra Vockova, Mariana Pacheco-Blanco, Kristina Forsterova, Karel Helman, Eva Pokorna, Diana Tuskova, Zuzana Zemanova, Karla Svobodova, Jan Soukup, Ondrej Havranek, Magdalena Klanova, Michael Svaton, Jana Karolova, Zuzana Nahacka, Ladislav Andera, Dana Prukova
Supplemental Figure 1. Next-generation sequencing of PDXs and primary MCL cells Supplemental Figure 2. IHC analysis of primary MCL samples and murine xenografts Supplemental Figure 3. Array comparative genomic hybridization of 24 primary MCL samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9434da02e49e1026da548d1f72ae836
https://doi.org/10.1158/1078-0432.22471799
https://doi.org/10.1158/1078-0432.22471799
Autor:
Lan-Feng Dong, Jakub Rohlena, Renata Zobalova, Zuzana Nahacka, Anne-Marie Rodriguez, Michael V. Berridge, Jiri Neuzil
Publikováno v:
Journal of Cell Biology. 222
Mammalian genes were long thought to be constrained within somatic cells in most cell types. This concept was challenged recently when cellular organelles including mitochondria were shown to move between mammalian cells in culture via cytoplasmic br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55510d81d680da6acb4bd5fca780dddd
https://doi.org/10.1083/jcb.202211044
https://doi.org/10.1083/jcb.202211044
Autor:
Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova, Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova, Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Tomas Mracek, Hans Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini, T Iverson
Mitochondrial Complex II (CII) activity supports multiple types of respiration and connects metabolic state with succinate signaling. It is therefore unsurprising that CII activity has been linked to biological phenomena that require crosstalk betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daef871ae2d1f27caba9813786c90e52
https://doi.org/10.21203/rs.3.rs-2070392/v1
https://doi.org/10.21203/rs.3.rs-2070392/v1
Autor:
Jana Vondrakova, Michaela Frolikova, Lukas Ded, Jiri Cerny, Pavla Postlerova, Veronika Palenikova, Ondrej Simonik, Zuzana Nahacka, Krystof Basus, Eliska Valaskova, Radek Machan, Allan Pacey, Zuzana Holubcova, Pavel Koubek, Zuzana Ezrova, Soojin Park, Ruiwu Liu, Raghavendran Partha, Nathan Clark, Jiri Neuzil, Masahito Ikawa, Kent Erickson, Kit S. Lam, Harry Moore, Katerina Komrskova
Publikováno v:
Science advances, vol 8, iss 36
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdc4dfa16fe9d3deef71513ee2b1172
https://pubmed.ncbi.nlm.nih.gov/36070373
https://pubmed.ncbi.nlm.nih.gov/36070373
Autor:
Jun Zhu, Jiri Cerny, Ivana Jochmanova, Stepana Boukalova, Renata Zobalova, Sarka Dvorakova, Igor Hartmann, Hans K. Ghayee, Philip E. Knapp, Linda Krobova, Karel Pacak, Naris Nilubol, Svetlana Pack, Chunzhang Yang, Katerina Vanova, Timothy J. Garrett, David Taïeb, Zdenek Frysak, Thanh-Truc Huynh, Sona Hubackova, Xiaolin Wu, Jiri Neuzil, Bjoern Schuster, Zuzana Nahacka, Michal Kraus, Jakub Rohlena, Ying Pang, Ondrej Uher
Publikováno v:
JNCI: Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), 2021, ⟨10.1093/jnci/djab158⟩
J Natl Cancer Inst
JNCI: Journal of the National Cancer Institute, 2021, ⟨10.1093/jnci/djab158⟩
JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), 2021, ⟨10.1093/jnci/djab158⟩
J Natl Cancer Inst
JNCI: Journal of the National Cancer Institute, 2021, ⟨10.1093/jnci/djab158⟩
Background Pheochromocytoma and paraganglioma (PPGL) are neuroendocrine tumors with frequent mutations in genes linked to the tricarboxylic acid cycle. However, no pathogenic variant has been found to date in succinyl-CoA ligase (SUCL), an enzyme tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2aa1869938b84d91120423c608deee
https://hal.archives-ouvertes.fr/hal-03363895
https://hal.archives-ouvertes.fr/hal-03363895
Autor:
Michael Svaton, Zuzana Zemanova, Marek Trneny, Zuzana Nahacka, Magdalena Klanova, Jan Soukup, Mariana Pacheco-Blanco, Dana Prukova, Kristina Forsterova, Eva Fronkova, Jana Karolova, Karel Helman, Ladislav Andera, Pavel Klener, Karla Svobodova, Eva Pokorná, Ondrej Havranek, Petra Vockova, Adela Berkova, Diana Tuskova
Publikováno v:
Clinical Cancer Research. 25:4455-4465
Purpose: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6df51da911e3b076be45522ead8d4b6
https://doi.org/10.1158/1078-0432.ccr-18-3275
https://doi.org/10.1158/1078-0432.ccr-18-3275