Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zuzana Horejsi"'
Autor:
Anna Konopka, Donna R. Whelan, Md Shafi Jamali, Emma Perri, Hamideh Shahheydari, Reka P. Toth, Sonam Parakh, Tina Robinson, Alison Cheong, Prachi Mehta, Marta Vidal, Audrey M. G. Ragagnin, Ivan Khizhnyak, Cyril J. Jagaraj, Jasmin Galper, Natalie Grima, Anand Deva, Sina Shadfar, Garth A. Nicholson, Shu Yang, Suzanne M. Cutts, Zuzana Horejsi, Toby D. M. Bell, Adam K. Walker, Ian P. Blair, Julie D. Atkin
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-28 (2020)
Abstract Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain of TDP-43 functions
Externí odkaz:
https://doaj.org/article/3003b649896947f29c746f302d459637
Autor:
Alison Cheong, Sonam Parakh, Sina Shadfar, Prachi Mehta, Shu Yang, Anand K. Deva, Anna Konopka, Natalie Grima, Adam K. Walker, Cyril J. Jagaraj, Emma R. Perri, Suzanne M. Cutts, Tina Robinson, Garth A. Nicholson, Hamideh Shahheydari, Reka P. Toth, Shafi Jamali, Julie D. Atkin, Audrey Ragagnin, Ian P. Blair, Toby D. M. Bell, Zuzana Horejsi, Marta Vidal, Ivan Khizhnyak, Donna R. Whelan, Jasmin Galper
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-28 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are also present in ALS. Loss and gain of TDP-43 functions are impli
Publikováno v:
Biology of the Cell. 110:137-146
Background information Repair of damaged DNA is essential for maintaining genomic stability. TP53-binding protein 1 (53BP1) plays an important role in repair of the DNA double-strand breaks. Nuclear localisation of 53BP1 depends on importin β and nu
Autor:
Jay Oza, Antoinette R. Tan, Honeah Sohail, Atul Kulkarni, Antonia Tomás-Loba, Zuzana Horejsi, Vasudeva Ginjala, Ming Yao, Simon J. Boulton, Shridar Ganesan
Publikováno v:
Journal of Biological Chemistry. 288:32357-32369
Activation of poly(ADP-ribose) polymerase (PARP) near sites of DNA breaks facilitates recruitment of DNA repair proteins and promotes chromatin relaxation in part through the action of chromatin-remodeling enzyme Amplified in Liver Cancer 1 (ALC1). T
Autor:
Pavel Hozák, Sona Hubackova, Zdenek Hodny, Jana Dobrovolna, Zuzana Horejsi, L Janderova-Rossmeislova, Zora Novakova, Pavla Vasicova, Marketa Vancurova, Martin Kosar, Jiri Bartek
Publikováno v:
Oncogene
Oncogene; Vol 29
Oncogene; Vol 29
Cellular senescence guards against cancer and modulates aging; however, the underlying mechanisms remain poorly understood. Here, we show that genotoxic drugs capable of inducing premature senescence in normal and cancer cells, such as 5-bromo-2'-deo
Autor:
Arlinda Dullovi, Meryem Ozgencil, Vinothini Rajvee, Wai Yiu Tse, Pedro R. Cutillas, Sarah A. Martin, Zuzana Hořejší
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106107- (2023)
Summary: The DNA-damage response is a complex signaling network that guards genomic integrity. The microtubule cytoskeleton is involved in the repair of DNA double-strand breaks; however, little is known about which cytoskeleton-related proteins are
Externí odkaz:
https://doaj.org/article/59f0d612b282420fb66d26bbfc917799
Autor:
Zuzana Horejsi, Maxwell Sehested, Jiri Bartek, Manuel Stucki, Niels E. Skakkebæk, Jahn M. Nesland, Rajpert-De Meyts E, Jiri Lukas, Stephen P. Jackson, J Bartkova
Publikováno v:
Oncogene. 26:7414-7422
MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards against cancer, yet the tissue expression patterns and involvement of these two DDR adaptors/mediators in human tumours remain
Autor:
Jiri Bartek, Zuzana Horejsi, Frederic Tort, Alwin Krämer, Torben F. Ørntoft, Maxwell Sehested, Jahn M. Nesland, Jiri Lukas, Karsten Zieger, Jirina Bartkova, Claudia Lukas, Per Guldberg, Karen Koed
Publikováno v:
Bartkova, J, Horejsi, Z, Koed, K, Kramer, A, Tort, F, Zieger, K, Guldberg, P, Sehested, M, Nesland, J M, Lukas, C, Ørntoft, T F, Lukas, J & Bartek, J 2005, ' DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis ', Nature, vol. 434, no. 7035 .
During the evolution of cancer, the incipient tumour experiences 'oncogenic stress', which evokes a counter-response to eliminate such hazardous cells. However, the nature of this stress remains elusive, as does the inducible anti-cancer barrier that
Publikováno v:
Oncogene. 22:665-673
The genes involved in the transformation of kidney blastema cells were searched for in avian nephroblastomas induced by the MAV2 retrovirus. The twist gene was identified as a common site of provirus integration in tumor cells. Twist was rearranged b
Autor:
Zuzana Horejsi, J. Mark Skehel, Charles Swanton, Carrie A. Adelman, Olga Murina, Rafal L. Lolo, Gordon Stamp, Kenichiro Matsuzaki, Simon J. Boulton, Kalindi Parmar, Alessandro A. Sartori, Nicolai Juul Birkbak, Alan D. D'Andrea, Valerie Borel
Publikováno v:
Nature
Repair of interstrand crosslinks (ICLs) requires the coordinated action of the intra-S-phase checkpoint and the Fanconi anaemia pathway, which promote ICL incision, translesion synthesis and homologous recombination (reviewed in refs 1, 2). Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60619ef526dc8e1e4db978786e529af2
https://doi.org/10.5167/uzh-81043
https://doi.org/10.5167/uzh-81043