Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Zuzana Drobná"'
Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A
Publikováno v:
Stem Cell Reports
Summary Angelman syndrome is a complex neurodevelopmental disorder characterized by delayed development, intellectual disability, speech impairment, and ataxia. It results from the loss of UBE3A protein, an E3 ubiquitin ligase, in neurons of the brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d561bb1b87df41dc68bfd4bd8839c8
http://europepmc.org/articles/PMC7561513
http://europepmc.org/articles/PMC7561513
Autor:
Jodi A. Flaws, Emilie F. Rissman, Anne D Henriksen, Joshua W. Irvin, Rachel Stevenson, Jessica A. Goldsby, Jennifer T. Wolstenholme, Zuzana Drobná
Publikováno v:
Endocrinology
Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857174052b06b4e2b13624d7745cbf4e
https://doi.org/10.1210/en.2019-00196
https://doi.org/10.1210/en.2019-00196
Autor:
Emilie F. Rissman, Timothy R. Fennell, Alzbeta Talarovicova, Hannah E. Schrader, Rodney W. Snyder, Zuzana Drobná
Publikováno v:
Toxicology
Bisphenol S (2,2-bisulfone, BPS) and Bisphenol F (2,2-bis [4-hydroxyphenol]methane, BPF) are analogs of Bisphenol A (2,2-bis[4-hydroxyphenyl]propane, BPA), a widely used endocrine disrupting compound present in polycarbonate plastics, thermal receipt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67feba9507bcffe755726fa910235f79
https://doi.org/10.1016/j.tox.2019.03.016
https://doi.org/10.1016/j.tox.2019.03.016
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
UBE3A is an E3 ubiquitin ligase encoded by the neurally imprinted UBE3A gene. The abundance and subcellular distribution of UBE3A has been the topic of many previous studies as its dosage and localization has been linked to neurodevelopmental disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63bb33def3b3b775ce3154c05b6572f
http://europepmc.org/articles/PMC7973473
http://europepmc.org/articles/PMC7973473
Autor:
Mazhar Adli, Erin P. Harris, Jennifer T. Wolstenholme, Changqing Zhou, Philip S. Lambeth, Stephen Shang, Anne D Henriksen, Jodi A. Flaws, Catalina Montiel, Emilie F. Rissman, Zuzana Drobná
Publikováno v:
Endocrinology. 159:132-144
Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). Developmental exposure to BPA changes behavioral and reproductive phenotypes, and these effects can last for generations. We exposed embryos to BPA, producing two lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ae821441afc694c7782bf8c8d6b2f1
https://doi.org/10.1210/en.2017-00730
https://doi.org/10.1210/en.2017-00730
Autor:
Jessica E. Laine, Wimal Pathmasiri, Susan Sumner, Susan McRitchie, Lisa Smeester, Kathryn A. Bailey, Rebecca C. Fry, Gonzalo G. García-Vargas, Zuzana Drobná, Christelle Douillet, Marisela Rubio-Andrade, Andrew F. Olshan, Miroslav Stýblo
Publikováno v:
Environmental Science & Technology. 51:625-633
Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b6bf534983688f386a060bd353d219
https://doi.org/10.1021/acs.est.6b04374
https://doi.org/10.1021/acs.est.6b04374
SUMMARYHuman neurodevelopment and its associated diseases are complex and challenging to study. This has driven recent excitement for human cerebral organoids (hCOs) as research and screening tools. These models are steadily proving their utility; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785cbc2d241f8e503d66b20a72b7cadb
https://doi.org/10.1101/742213
https://doi.org/10.1101/742213
Autor:
Zuzana Drobná
Publikováno v:
Toxicology and Applied Pharmacology. 408:115278
Arsenic is a neurotoxin and environmental exposure to it correlates with an incidence of neurodegenerative diseases. Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bd9380925c90d76c38442f163cd286
https://doi.org/10.1016/j.taap.2020.115278
https://doi.org/10.1016/j.taap.2020.115278
Autor:
Ana Navas Acien, Frederick W. Miller, Maria Grau Perez, Angela D. Liese, Richard F. Hamman, Chongben Zang, Michelle A. Mendez, Robin C. Puett, Chin-Chi Kuo, Miroslav Styblo, Kristina A. Thayer, Miranda Spratlen, Dana Dabelea, William C. Knowler, Christelle Douillet, Zuzana Drobná, Ronny A. Bell, Elizabeth J. Mayer-Davis, John L. Adgate
Publikováno v:
Diabetes Care
OBJECTIVE Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788b5109ddb23f4cf1ec52de5cadbb61
https://doi.org/10.2337/dc16-0810
https://doi.org/10.2337/dc16-0810
Publikováno v:
Journal of Environmental Sciences. 49:104-112
Arsenic methyltransferase (As3mt) catalyzes the conversion of inorganic arsenic (iAs) to its methylated metabolites, including toxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII). Knockout (KO) of As3mt was shown to reduce the capacity to me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06577188a2020dbacf9339e22e8823c
https://doi.org/10.1016/j.jes.2016.06.018
https://doi.org/10.1016/j.jes.2016.06.018