Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Zuzana Bielcikova"'
Autor:
Zuzana Bielcikova, Lukas Werner, Jan Stursa, Vladimir Cerny, Ludmila Krizova, Jan Spacek, Stanislav Hlousek, Michal Vocka, Olga Bartosova, Michal Pesta, Katarina Kolostova, Petr Klezl, Vladimir Bobek, Jaroslav Truksa, Sona Stemberkova-Hubackova, Lubos Petruzelka, Pavel Michalek, Jiri Neuzil
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Mitochondrially targeted anticancer drugs (mitocans) that disrupt the energy-producing systems of cancer are emerging as new potential therapeutics. Mitochondrially targeted tamoxifen (MitoTam), an inhibitor of mitochondrial respiration respiratory c
Externí odkaz:
https://doaj.org/article/269f239884f64e4ea206c5d48ff311b3
Autor:
Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)
Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods
Externí odkaz:
https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c
Publikováno v:
Cancers, Vol 15, Iss 18, p 4476 (2023)
A recent paper published in Nature Medicine reported on the Phase I clinical trial of a mitochondria-targeting anti-cancer agent IACS-01059 in patients with acute myeloid leukemia (AML) and solid tumors [...]
Externí odkaz:
https://doaj.org/article/50db9fdb6acc45ae9e63d8d3d91c68b4
Autor:
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Senescent cells play a role in pathogenesis of diabetes, and senolytic agents can improve obesity- and diabetes-related pathologies. Here the authors report that mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activit
Externí odkaz:
https://doaj.org/article/e1a97d3a7b444e588a78bce984149ca2
Autor:
Sona Stemberkova‐Hubackova, Renata Zobalova, Maria Dubisova, Jana Smigova, Sarka Dvorakova, Klara Korinkova, Zuzana Ezrova, Berwini Endaya, Kristyna Blazkova, Erik Vlcak, Petra Brisudova, Dan‐Diem Thi Le, Stefan Juhas, Daniel Rosel, Cristina Daniela Kelemen, Dana Sovilj, Eliska Vacurova, Tomas Cajka, Vlada Filimonenko, Lanfeng Dong, Ladislav Andera, Pavel Hozak, Jan Brabek, Zuzana Bielcikova, Jan Stursa, Lukas Werner, Jiri Neuzil
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/6ffa7e718404400f926a4f1d5c918cd7
Autor:
Martina Zimovjanova, Zuzana Bielcikova, Michaela Miskovicova, Michal Vocka, Anna Zimovjanova, Marian Rybar, Jan Novotny, Lubos Petruzelka
Publikováno v:
Cancers, Vol 15, Iss 4, p 1072 (2023)
Unnafected female carriers of BRCA1 and BRCA2 pathogenic/likely pathogenic variants (P/LPVs) are at higher risk of breast cancer (BC) and ovarian cancer (OC). In the retrospective single-institution study in the Czech Republic, we analyzed the rate,
Externí odkaz:
https://doaj.org/article/667509aa8bf246fc94523f2b072f1385
Autor:
Anna Jakabova, Zuzana Bielcikova, Eliska Pospisilova, Lubos Petruzelka, Piotr Blasiak, Vladimir Bobek, Katarina Kolostova
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background and Aims: The aim of this study was to characterize circulating tumor cells (CTCs) during neoadjuvant chemotherapy (NACT) in early and locally advanced breast cancer (LABC) patients. Using ultrasound, tumor volume measurement was compared
Externí odkaz:
https://doaj.org/article/c831b9a9147045a8ab267b01a0f7c99e
Autor:
Michal Vocka, Martina Zimovjanova, Zuzana Bielcikova, Petra Tesarova, Lubos Petruzelka, Martin Mateju, Ludmila Krizova, Jaroslav Kotlas, Jana Soukupova, Marketa Janatova, Petra Zemankova, Petra Kleiblova, Jan Novotny, Bohuslav Konopasek, Martina Chodacka, Milan Brychta, Marek Sochor, Denisa Smejkalova-Musilova, Vlastimila Cmejlova, Renata Kozevnikovova, Lenka Miskarova, Sona Argalacsova, Lenka Stolarova, Klara Lhotova, Marianna Borecka, Zdenek Kleibl
Publikováno v:
Cancers, Vol 11, Iss 6, p 738 (2019)
Breast cancer (BC) prognosis in BRCA1 and BRCA2 mutation carriers has been reported contradictorily, and the significance of variables influencing prognosis in sporadic BC is not established in BC patients with hereditary BRCA1/BRCA2 mutations. In th
Externí odkaz:
https://doaj.org/article/397dffc6e38347ff8d5660ff71b42cc0
Autor:
Zuzana Bielcikova, Milos Holanek, Iveta Selingerova, Ondrej Sorejs, Iveta Kolarova, Renata Soumarova, Jan Proks, Lucie Reifova, Vlastimila Cmejlova, Lenka Linkova, Michaela Zabojnikova, Martina Chodacka, Lucie Janovska, Lenka Lisnerova, Karolina Kasparova, Denisa Pohankova
Purpose To analyze clinicopathologic characteristics, treatment procedures, and prognosis of men with breast cancer (MBC) in the Czech Republic and compare them with international data. Methods Men diagnosed with breast cancer in 2007–2017 were ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d984e32cabcaa5c8a7fba67af34f974
https://doi.org/10.21203/rs.3.rs-2748844/v1
https://doi.org/10.21203/rs.3.rs-2748844/v1
Autor:
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v:
Nature communications. 13(1)
Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochon