Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zuzana Šišková"'
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55004 (2013)
Synaptic abnormalities, one of the key features of prion disease pathogenesis, gives rise to functional deficits and contributes to the devastating clinical outcome. The synaptic compartment is the first to succumb in several neurodegenerative diseas
Externí odkaz:
https://doaj.org/article/4d8917b782234c9ab22c4fe4048e3143
Autor:
Zuzana Šišková, Marie-Ève Tremblay
Publikováno v:
Neural Plasticity, Vol 2013 (2013)
A series of discoveries spanning for the last few years has challenged our view of microglial function, the main form of immune defense in the brain. The surveillance of neuronal circuits executed by each microglial cell overseeing its territory occu
Externí odkaz:
https://doaj.org/article/49c3aef3e63b4c50b735f544e62e7eb8
Autor:
Lars Krüger, Eva-Maria Mandelkow, Zuzana Šišková, Eckhard Mandelkow, Jochen Martin Decker, Astrid Sydow, Frank J.A. Dennissen
Publikováno v:
EMBO reports 17(4), 552-569 (2016). doi:10.15252/embr.201541439
We report on a novel transgenic mouse model expressing human full-length Tau with the Tau mutation A152T (hTau(AT)), a risk factor for FTD-spectrum disorders including PSP and CBD Brain neurons reveal pathological Tau conformation, hyperphosphorylati
Autor:
Marie-Ève Tremblay, Zuzana Šišková
Publikováno v:
Neural Plasticity
Scopus-Elsevier
Neural Plasticity, Vol 2013 (2013)
Neural plasticity 2013, 1-10 (2013). doi:10.1155/2013/425845
Scopus-Elsevier
Neural Plasticity, Vol 2013 (2013)
Neural plasticity 2013, 1-10 (2013). doi:10.1155/2013/425845
A series of discoveries spanning for the last few years has challenged our view of microglial function, the main form of immune defense in the brain. The surveillance of neuronal circuits executed by each microglial cell overseeing its territory occu
Autor:
Zuzana Šišková
Publikováno v:
Prion 7(4), 291-293 (2013). doi:10.4161/pri.26019
Structure is a key determinant of function, with the nervous system being no exception. For example, in the nervous system the physiological properties of different synapses may be understood by comparing their structures. However, it is not clear wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b89e751a66542b24e772961a1c26206
Publikováno v:
Folding for the Synapse ISBN: 9781441970602
The synapse has emerged as a major target for the misfolding insults that underlie prion disease and many other proteinopathies (e.g., Alzheimer’s disease (AD)). This common theme in the pathogenesis of these disorders indicates that analogous dege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca53264a9027ab6e7e3077dbfa37df5
https://doi.org/10.1007/978-1-4419-7061-9_15
https://doi.org/10.1007/978-1-4419-7061-9_15
Autor:
Julika Pitsch, Susanne Schoch, Daniel Justus, Tatjana Beutel, Stefan Remy, Zuzana Šišková, Albert J. Becker, Detlef Friedrichs, Heinz Von Der Kammer, Niklas Henneberg, Hiroshi Kaneko
Publikováno v:
Neuron 84(5), 1023-1033 (2014). doi:10.1016/j.neuron.2014.10.024
SummaryDendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized c
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 1, Pp 63-74 (2009)
Intrahippocampal injection of the murine modified scrapie (ME7) induces a model of prion disease in vivo. Animals inoculated with ME7 brain homogenate were compared to controls at 8, 12 and 21 weeks. The data show that the accumulation of misfolded p
Externí odkaz:
https://doaj.org/article/b2f28733b024490d850c2be66da5c15e
Autor:
Matteo Caleo, Laura Restani, Eleonora Vannini, Zuzana Siskova, Hussain Al-Malki, Ruth Morgan, Vincent O'Connor, V Hugh Perry
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41182 (2012)
In chronic neurodegenerative diseases associated with aggregates of misfolded proteins (such as Alzheimer's, Parkinson's and prion disease), there is an early degeneration of presynaptic terminals prior to the loss of the neuronal somata. Identifying
Externí odkaz:
https://doaj.org/article/676cfc8ac4f84feaa42a0888ba29cbcc