Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

Autor: Amanda J Martinot, Mary Farrow, Lu Bai, Emilie Layre, Tan-Yun Cheng, Jennifer H Tsai, Jahangir Iqbal, John W Annand, Zuri A Sullivan, M Mahmood Hussain, James Sacchettini, D Branch Moody, Jessica C Seeliger, Eric J Rubin

Publikováno v: PLoS Pathogens, Vol 12, Iss 1, p e1005351 (2016)

Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to int

Externí odkaz: https://doaj.org/article/3122182a17664a31b85cc45e21e4b8b4

Mapping the cellular and molecular organization of mouse cerebral aging by single-cell transcriptome imaging

Autor: William E. Allen, Timothy R. Blosser, Zuri A. Sullivan, Catherine Dulac, Xiaowei Zhuang

SummaryThe cellular diversity and complex organization of the brain have hindered systematic characterization of age-related changes in its cellular and molecular architecture, limiting our ability to understand the mechanisms underlying its function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ae63c464cd62a80ba8c9877988d3766
https://doi.org/10.1101/2022.09.14.508048

Food allergy as a biological food quality control system

Autor: Ruslan Medzhitov, Esther Florsheim, William Khoury-Hanold, Zuri A. Sullivan

Publikováno v: Cell. 184:1440-1454

Food is simultaneously a source of essential nutrients and a potential source of lethal toxins and pathogens. Consequently, multiple sensory mechanisms evolved to monitor the quality of food based on the presence and relative abundance of beneficial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cd15ed85f69db3275860befa6796f5
https://doi.org/10.1016/j.cell.2020.12.007

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Autor: Prinita Baijnath, Leon Naidoo, Eisa Mahyari, Bongiwe Z. Xulu, Kelly L. Miners, William R. Bishai, Umesh G. Lalloo, Morten Nielsen, Moosa Suleman, Victoria O. Kasprowicz, Rajhmun Madansein, Thumbi Ndung'u, Prabhat K. Sharma, Erin W. Meermeier, David M. Lewinsohn, David Price, Aneta H. Worley, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, Zoe Rogers, Zuri A. Sullivan, Alasdair Leslie, Henrik N. Kløverpris, James E. McLaren, Kristin Ladell, Samuel M. Behar, Anish Ambaram

Publikováno v: Communications Biology
Wong, E B, Gold, M C, Meermeier, E W, Xulu, B Z, Khuzwayo, S, Sullivan, Z A, Mahyari, E, Rogers, Z, Kløverpris, H, Sharma, P K, Worley, A H, Lalloo, U, Baijnath, P, Ambaram, A, Naidoo, L, Suleman, M, Madansein, R, McLaren, J E, Ladell, K, Miners, K L, Price, D A, Behar, S M, Nielsen, M, Kasprowicz, V O, Leslie, A, Bishai, W R, Ndung'u, T & Lewinsohn, D M 2019, ' TRAV1-2 + CD8 + T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis ', Communications Biology, vol. 2, 203 . https://doi.org/10.1038/s42003-019-0442-2
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Wong, E B, Gold, M C, Meermeier, E W, Xulu, B Z, Khuzwayo, S, Sullivan, Z A, Mahyari, E, Rogers, Z, Kløverpris, H, Sharma, P K, Worley, A H, Lalloo, U, Baijnath, P, Ambaram, A, Naidoo, L, Suleman, M, Madansein, R, McLaren, J E, Ladell, K, Miners, K L, Price, D A, Behar, S M, Nielsen, M, Kasprowicz, V O, Leslie, A, Bishai, W R, Ndung’u, T & Lewinsohn, D M 2019, ' TRAV1-2 + CD8 + T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis ', Communications Biology, vol. 2, no. 1, 203 . https://doi.org/10.1038/s42003-019-0442-2

Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2+ semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4817cecf805d1a194b666c2f42cd6a6b

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

Autor: Emilie Layre, Jennifer H.C. Tsai, Jessica C. Seeliger, James C. Sacchettini, John W. Annand, M. Mahmood Hussain, Tan-Yun Cheng, Eric J. Rubin, Mary F. Farrow, Lu Bai, Zuri A. Sullivan, Jahangir Iqbal, D. Branch Moody, Amanda J. Martinot

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 1, p e1005351 (2016)

Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd7e1ccbef9cba1f05b6ab3cf2f2983
http://europepmc.org/articles/PMC4709180