Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.

Autor: Full F; Department of Microbiology, The University of Chicago, Chicago, IL, USA.; Institute for Clinical and Molecular Virology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany., van Gent M; Department of Microbiology, The University of Chicago, Chicago, IL, USA., Sparrer KMJ; Department of Microbiology, The University of Chicago, Chicago, IL, USA.; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Chiang C; Department of Microbiology, The University of Chicago, Chicago, IL, USA., Zurenski MA; Department of Microbiology, The University of Chicago, Chicago, IL, USA., Scherer M; Institute of Virology, Ulm University Medical Center, Ulm, Germany., Brockmeyer NH; Department of Dermatology, Venerology, and Allergology, Center for Sexual Health and Medicine, Ruhr University Bochum, Bochum, Germany., Heinzerling L; Department of Dermatology, University Hospital Erlangen, Erlangen, Germany., Stürzl M; Division of Molecular and Experimental Surgery, Department of Surgery, University Hospital Erlangen, Erlangen, Germany., Korn K; Institute for Clinical and Molecular Virology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany., Stamminger T; Institute of Virology, Ulm University Medical Center, Ulm, Germany., Ensser A; Institute for Clinical and Molecular Virology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany., Gack MU; Department of Microbiology, The University of Chicago, Chicago, IL, USA. mgack@uchicago.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Jan; Vol. 4 (1), pp. 164-176. Date of Electronic Publication: 2018 Nov 12.

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

Autor: Meisel M; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Hinterleitner R; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Pacis A; Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.; Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Chen L; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Earley ZM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Mayassi T; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Pierre JF; Department of Medicine, University of Chicago, Chicago, IL, USA.; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA., Ernest JD; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Galipeau HJ; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Thuille N; Translational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria., Bouziat R; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Buscarlet M; Research Centre, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada., Ringus DL; Department of Medicine, University of Chicago, Chicago, IL, USA., Wang Y; Department of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA., Li Y; Department of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA., Dinh V; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Kim SM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., McDonald BD; Department of Medicine, University of Chicago, Chicago, IL, USA.; Department of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA., Zurenski MA; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Musch MW; Department of Medicine, University of Chicago, Chicago, IL, USA., Furtado GC; Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lira SA; Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baier G; Translational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria., Chang EB; Department of Medicine, University of Chicago, Chicago, IL, USA., Eren AM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Marine Biological Laboratory, Woods Hole, MA, USA., Weber CR; Department of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA., Busque L; Research Centre, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.; Hematology Division, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, Quebec, Canada., Godley LA; Department of Medicine, University of Chicago, Chicago, IL, USA.; Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA., Verdú EF; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Barreiro LB; Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.; Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Jabri B; Department of Medicine, University of Chicago, Chicago, IL, USA. bjabri@bsd.uchicago.edu.; Committee on Immunology, University of Chicago, Chicago, IL, USA. bjabri@bsd.uchicago.edu.; Department of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA. bjabri@bsd.uchicago.edu.

Publikováno v: Nature [Nature] 2018 May; Vol. 557 (7706), pp. 580-584. Date of Electronic Publication: 2018 May 16.

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.

Autor: Bouziat R; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Hinterleitner R; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Brown JJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA., Stencel-Baerenwald JE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA., Ikizler M; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Mayassi T; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Meisel M; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Kim SM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Discepolo V; Department of Medicine, University of Chicago, Chicago, IL, USA.; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, and CeInGe-Biotecnologie Avanzate, Naples, Italy., Pruijssers AJ; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Ernest JD; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Iskarpatyoti JA; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Costes LM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, Netherlands., Lawrence I; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Palanski BA; Department of Chemistry, Stanford University, Stanford, CA, USA., Varma M; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Zurenski MA; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA., Khomandiak S; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., McAllister N; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA., Aravamudhan P; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Boehme KW; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Hu F; Department of Medicine, University of Chicago, Chicago, IL, USA., Samsom JN; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, Netherlands., Reinecker HC; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kupfer SS; Department of Medicine, University of Chicago, Chicago, IL, USA.; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA., Guandalini S; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Semrad CE; Department of Medicine, University of Chicago, Chicago, IL, USA.; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA., Abadie V; Department of Microbiology, Infectiology, and Immunology, University of Montreal, and the Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montreal, Quebec, Canada., Khosla C; Department of Chemistry, Stanford University, Stanford, CA, USA.; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.; Stanford ChEM-H, Stanford University, Stanford, California, USA., Barreiro LB; Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada., Xavier RJ; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ng A; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Dermody TS; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. bjabri@bsd.uchicago.edu terence.dermody@chp.edu.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Jabri B; Department of Medicine, University of Chicago, Chicago, IL, USA. bjabri@bsd.uchicago.edu terence.dermody@chp.edu.; Committee on Immunology, University of Chicago, Chicago, IL, USA.; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Department of Pathology, University of Chicago, Chicago, IL, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2017 Apr 07; Vol. 356 (6333), pp. 44-50.

IL-23 induces IL-22 and IL-17 production in response to Chlamydia muridarum genital tract infection, but the absence of these cytokines does not influence disease pathogenesis.

Autor: Frazer LC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA., Scurlock AM, Zurenski MA, Riley MM, Mintus M, Pociask DA, Sullivan JE, Andrews CW Jr, Darville T

Publikováno v: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2013 Dec; Vol. 70 (6), pp. 472-84.

The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfection.

Autor: Riley MM; Children's Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Zurenski MA, Frazer LC, O'Connell CM, Andrews CW Jr, Mintus M, Darville T

Publikováno v: Infection and immunity [Infect Immun] 2012 Jun; Vol. 80 (6), pp. 2194-203. Date of Electronic Publication: 2012 Mar 19.