Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Zuqiang Liu"'
Publikováno v:
Buildings, Vol 13, Iss 5, p 1245 (2023)
Many factors influence structural reliability in practice engineering. Some factors can be measured to obtain lots of data, but others are difficult to acquire statistical data. In view of this situation, a new structural reliability analysis method
Externí odkaz:
https://doaj.org/article/7535861fb71c4728a1fff8df4e0b3849
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 350-360 (2020)
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival. We have utilized bilateral flank tumor models to determine the most efficacious re
Externí odkaz:
https://doaj.org/article/e97e2186645e413e848c73adf5e79d7d
Autor:
Zong Sheng Guo, Binfeng Lu, Zongbi Guo, Esther Giehl, Mathilde Feist, Enyong Dai, Weilin Liu, Walter J. Storkus, Yukai He, Zuqiang Liu, David L. Bartlett
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-21 (2019)
Abstract Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with potential to provide greater clinical benefit to patients with advanced-stage cancer. In particular, recombinant vaccinia viruses (VV) hold great promise as
Externí odkaz:
https://doaj.org/article/dd58871640dd4377a7310da801381607
Autor:
Esther Giehl, Hiromichi Kosaka, Zuqiang Liu, Mathilde Feist, Udai S. Kammula, Michael T. Lotze, Congrong Ma, Zong Sheng Guo, David L. Bartlett
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes (TIL) achieves durable clinical benefit for patients from whom these cells can be derived in advanced metastatic melanoma but is limited in most solid tumors as a result of i
Externí odkaz:
https://doaj.org/article/525f6f107eda4fd488a555127d5b674c
Autor:
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1425 (2022)
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides. In this study, we explore the combination of a ferroptosis activator with an oncolytic vaccinia virus in tumor models. Erastin
Externí odkaz:
https://doaj.org/article/845fcbfbe9d346f2adef10925b7e5237
Autor:
David L Bartlett, Yan Ge, Zong Sheng Guo, Enyong Dai, Weilin Liu, Zuqiang Liu, Haiyan Wang, Jinghua Ren, Lingjuan Chen, Hongqi Chen, Junjie Ye, Congrong Ma, Songguang Ju
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Immune checkpoint blockade is arguably the most effective current cancer therapy approach; however, its efficacy is limited to patients with “hot” tumors, warranting an effective approach to transform “cold” tumors. Oncolytic viruses (especia
Externí odkaz:
https://doaj.org/article/7cea4f5916d54791aead8e66d2c50f42
Autor:
Zuqiang Liu, Yan Ge, Haiyan Wang, Congrong Ma, Mathilde Feist, Songguang Ju, Z. Sheng Guo, David L. Bartlett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
IL-2 is used systemically for cancer therapy but it is associated with severe toxicity. Here, the authors design a recombinant vaccinia virus expressing membrane-bound IL-2 that shows therapeutic efficacy alone or in combination with checkpoint inhib
Externí odkaz:
https://doaj.org/article/bf8c62b2e7b9492694731295e94b4d6e
Autor:
Zong Sheng Guo, Zuqiang Liu, Magesh Sathaiah, Jiahu Wang, Roshni Ravindranathan, Eun Kim, Shaohua Huang, Thomas W. Kenniston, John C. Bell, Herbert J. Zeh, III, Lisa H. Butterfield, Andrea Gambotto, David L. Bartlett
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 112-122 (2017)
Recombinant poxviruses, utilized as vaccine vectors and oncolytic viruses, often require manipulation at multiple genetic loci in the viral genome. It is essential for viral vectors to possess no adventitious mutations and no (antibiotic) selection m
Externí odkaz:
https://doaj.org/article/05ef89663b524fc8a998300b00359fe8
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody e
Externí odkaz:
https://doaj.org/article/08d52995317b46989e958cc19d18bdfc
Autor:
Zuqiang Liu, Xingxing Hao, Yi Zhang, Jiying Zhang, Cara D. Carey, Louis D. Falo, Walter J. Storkus, Zhaoyang You
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
The progressive tumor microenvironment (TME) coordinately supports tumor cell expansion and metastasis, while it antagonizes the survival and (poly-)functionality of antitumor T effector cells. There remains a clear need to develop novel therapeutic
Externí odkaz:
https://doaj.org/article/35b8db487d9a45c1afff76d70f048341