Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Zuoshang Xu"'
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106414- (2024)
Alteration in protein citrullination (PC), a common posttranslational modification (PTM), contributes to pathogenesis in various inflammatory disorders. We previously reported that PC and protein arginine deiminase 2 (PAD2), the predominant enzyme is
Externí odkaz:
https://doaj.org/article/1f63fc7b49e34dcb88a7edb501c4a3da
Autor:
Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-8 (2022)
Abstract Chromosome 3-linked frontotemporal dementia (FTD3) is caused by a gain-of-function mutation in CHMP2B, resulting in the production of a truncated toxic protein, CHMP2BIntron5. Loss-of-function mutations in spastin are the most common genetic
Externí odkaz:
https://doaj.org/article/ba76bacd1a124f0f95d28998e3b5a5e0
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative diseases. PC is a posttranslational modification catalyzed by the PADs. PC converts peptidyl-arg
Externí odkaz:
https://doaj.org/article/083dc76ee24a464f8efb4c4ded95b115
Autor:
Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H Brown, Huaibin Cai, Zuoshang Xu
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0255710 (2022)
Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation
Externí odkaz:
https://doaj.org/article/ca05dfe95e714d5a948fa5b42faad5b5
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 3, Pp 578-586 (2006)
RNA interference (RNAi) has the potential to treat diseases caused by dominant, gain-of-function type of gene mutations. In these diseases, one allele is mutated and produces a toxic protein, whereas the other allele is normal and performs vital func
Externí odkaz:
https://doaj.org/article/57cd296678374c3985d6182b995bcce9
Publikováno v:
BioTechniques, Vol 41, Iss 1, Pp 64-68 (2006)
RNA interference (RNAi) has been increasingly used for reverse genetics. Both pol III and pol II promoters have been used to synthesize short hairpin RNA (shRNA) for knockdown of gene expression in mammalian cells and animals. Compared with gene knoc
Externí odkaz:
https://doaj.org/article/d1ace0ee0c3e4f8395d6b964f42e5ecf
Autor:
Teresa J Broering, Hongyan Wang, Naomi K Boatright, Yang Wang, Katherine Baptista, Gilda Shayan, Kerry A Garrity, Can Kayatekin, Daryl A Bosco, C Robert Matthews, Donna M Ambrosino, Zuoshang Xu, Gregory J Babcock
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61210 (2013)
Mutations in the gene encoding human SOD1 (hSOD1) can cause amyotrophic lateral sclerosis (ALS) yet the mechanism by which mutant SOD1 can induce ALS is not fully understood. There is currently no cure for ALS or treatment that significantly reduces
Externí odkaz:
https://doaj.org/article/d327649f499e4fa9bda858e4bcefd3f3
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e18778 (2011)
Transgenes flanked by loxP sites have been widely used to generate transgenic mice where the transgene expression can be controlled spatially and temporally by Cre recombinase. Data from this approach has led to important conclusions in cancer, neuro
Externí odkaz:
https://doaj.org/article/71058118c16e4592aa9453a850e211e5
Autor:
Chunxing Yang, Weijia Tan, Catheryne Whittle, Linghua Qiu, Lucheng Cao, Schahram Akbarian, Zuoshang Xu
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15878 (2010)
TAR DNA binding protein 43 KD (TDP-43) is an essential gene that regulates gene transcription, mRNA splicing and stability. In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal neurodegenerative diseases, TDP-43 is frag
Externí odkaz:
https://doaj.org/article/748f87edcbc74ad79ad5a8a26a85f614
Autor:
Dianne S Schwarz, Hongliu Ding, Lori Kennington, Jessica T Moore, Janell Schelter, Julja Burchard, Peter S Linsley, Neil Aronin, Zuoshang Xu, Phillip D Zamore
Publikováno v:
PLoS Genetics, Vol 2, Iss 9, p e140 (2006)
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that s
Externí odkaz:
https://doaj.org/article/eb326f6c2d474e3fb8c5df12834e5b11