Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zuoning Han"'
Publikováno v:
The Biochemical journal. 478(9)
Hepatic stellate cells (HSCs) are thought to play key roles in the development of liver fibrosis. Extensive evidence has established the concept that αV integrins are involved in the activation of latent transforming growth factor β (TGF-β), a mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88322546e7a4e2cda5bdf21ba569962a
https://pubmed.ncbi.nlm.nih.gov/33876829
https://pubmed.ncbi.nlm.nih.gov/33876829
Publikováno v:
Biochemical Journal; May2021, Vol. 478 Issue 9, p1689-1703, 15p
Publikováno v:
Arthritis & Rheumatism. 46:818-823
Objective Previous studies have demonstrated that inhibition of c-Jun N-terminal kinase (JNK) decreases joint destruction in the rat adjuvant arthritis model. The present study was undertaken to investigate whether selective loss of JNK-2 function de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0be3c22ae077fb17f53929a52bf80b
https://doi.org/10.1002/art.10104
https://doi.org/10.1002/art.10104
Autor:
David L. Boyle, Anthony M. Manning, Lufen Chang, Gary S. Firestein, Michael Karin, Li Yang, Zuoning Han, Brydon L. Bennett
Publikováno v:
Journal of Clinical Investigation. 108:73-81
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like synoviocytes and synovium. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7abc4b8f071a0ff8e68efc6eef1457
https://doi.org/10.1172/jci12466
https://doi.org/10.1172/jci12466
Autor:
Anthony M. Manning, Karlfried R. Aupperle, Brydon L. Bennett, Gary S. Firestein, Zuoning Han, David L. Boyle
Publikováno v:
The Journal of Immunology. 166:2705-2711
IκB kinase-1 and IκB kinase-2 (IKK1 and IKK2; also called IKKα and IKKβ, respectively) are part of the signal complex that regulates NF-κB activity in many cell types, including fibroblast-like synoviocytes (FLS). We determined which of these tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2882b134e38fd9283e6206a5a7de85d1
https://doi.org/10.4049/jimmunol.166.4.2705
https://doi.org/10.4049/jimmunol.166.4.2705
Autor:
Gary S. Firestein, David L. Boyle, Paul P. Tak, Lynn J. Ransone, Zuoning Han, Danielle M. Gerlag, Moorthy S. S. Palanki, Anthony M. Manning, Miguel Barbosa
Publikováno v:
The Journal of Immunology. 165:1652-1658
NF-κB plays a key role in the production of cytokines in inflammatory diseases. The effects of a novel T cell-specific NF-κB inhibitor, SP100030, were evaluated in cultured Jurkat cells and in murine collagen-induced arthritis (CIA). Chemical libra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e925a276ddd6bdb6d8b56021c2d30483
https://doi.org/10.4049/jimmunol.165.3.1652
https://doi.org/10.4049/jimmunol.165.3.1652
Publikováno v:
Autoimmunity. 28:197-208
To determine the expression and regulation of nuclear transcription factors AP-1 and NF-kappaB in rheumatoid arthritis and in collagen-induced arthritis in mice.AP-1 and NF-kappaB expression and function were determined in RA, OA and normal synovial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772ee06ce3a2f16fe4857fe4d9322bcb
https://doi.org/10.3109/08916939808995367
https://doi.org/10.3109/08916939808995367
Publikováno v:
Arthritis & Rheumatism. 40:1772-1779
Objective. To characterize the transcriptional and posttranscriptional regulation of collagenase-1 by adenosine receptor stimulation in interleukin-1 (IL-1)-stimulated fibroblast-like synoviocytes (FLS). Methods. FLS were stimulated with IL-1 and eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999e642899763c39877fdd808b9d7d40
https://doi.org/10.1002/art.1780401008
https://doi.org/10.1002/art.1780401008
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
In the course of a fragment screening campaign by in silico docking followed by X-ray crystallography, a novel binding site for migration inhibitory factor (MIF) inhibitors was demonstrated. The site is formed by rotation of the side-chain of Tyr-36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf85d44cd385f63be616f82b7a9d392
https://pubmed.ncbi.nlm.nih.gov/20185308
https://pubmed.ncbi.nlm.nih.gov/20185308
Autor:
Roy J. Vaz, Larry R. McLean, Ying Zhang, Hua Li, Yi Li, Joy Prisco, Ziyu Li, Choi Yong-Mi, Joseph T. Tsay, Zuoning Han, Stephan Reiling, Ulrike Lukasczyk, Jeremy Fordham
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
Biochemical and X-ray crystallographic studies confirmed that hydroxyquinoline derivatives identified by virtual screening were actually covalent inhibitors of the MIF tautomerase. Adducts were formed by N-alkylation of the Pro-1 at the catalytic sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd383e8d558cc5b0cf5ee20754de94e
https://pubmed.ncbi.nlm.nih.gov/19836948
https://pubmed.ncbi.nlm.nih.gov/19836948