Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zuokun Lu"'
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40345- (2024)
Cyclin Dependent Kinase 1 (CDK1) plays a crucial role in cell cycle regulation, and dysregulation of its activity has been implicated in various cancers. Although several CDK1 inhibitors are currently in clinical trials, none have yet been approved f
Externí odkaz:
https://doaj.org/article/02c542d0b12d4915884ef8f0de7c415a
Autor:
Hongliang Tian, Xiaoyun Ji, Xiaoyun Yang, Zhongxin Zhang, Zuokun Lu, Kailin Yang, Cheng Chen, Qi Zhao, Heng Chi, Zhongyu Mu, Wei Xie, Zefang Wang, Huiqiang Lou, Haitao Yang, Zihe Rao
Publikováno v:
Protein & Cell, Vol 7, Iss 8, Pp 562-570 (2016)
Abstract The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international
Externí odkaz:
https://doaj.org/article/48b276ca72ab4373ae700b94ea46ca5e
Autor:
Haitao Yang, Xiang Liu, Weihong Zhou, Han Wang, Luke W. Guddat, Christopher J. Schofield, Aili Zhang, Zihe Rao, Zuokun Lu, Cheng Yang
Because of β-lactamase–mediated resistance, β-lactam antibiotics were long considered ineffective drugs for tuberculosis (TB) treatment. However, some β-lactams, including meropenem and faropenem, are being re-evaluated in patients infected with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fedcaf708aeff7039577329a57679bf
https://doi.org/10.1124/mol.119.118042
https://doi.org/10.1124/mol.119.118042
Publikováno v:
Journal of Structural Biology. 213:107767
The enzymes exopolyphosphatase/guanosine pentaphosphate phosphohydrolase (PPX/GppA) play important roles in the bacterial stringent response. PPX degrades inorganic polyphosphate (polyP), a polymer composed of a few to hundreds of phosphate residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde4c9808700ee5c74c3ae4895aa7bee
https://doi.org/10.1016/j.jsb.2021.107767
https://doi.org/10.1016/j.jsb.2021.107767
Autor:
Zuokun, Lu, Han, Wang, Aili, Zhang, Xiang, Liu, Weihong, Zhou, Cheng, Yang, Luke, Guddat, Haitao, Yang, Christopher J, Schofield, Zihe, Rao
Publikováno v:
Molecular pharmacology. 97(4)
Because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7e7577fe7f6ab815697576c0a92f710
https://pubmed.ncbi.nlm.nih.gov/32086254
https://pubmed.ncbi.nlm.nih.gov/32086254
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:485-489
Mycobacterium tuberculosis, a major human pathogen, encodes at least 88 toxin–antitoxin (TA) systems. Remarkably, more than half of these modules belong to the VapBC family. Under normal growth conditions, the toxicity of the toxin VapC is neutrali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfc7382b18a26dba9aa4745c464ff39
https://doi.org/10.1107/s2053230x16007603
https://doi.org/10.1107/s2053230x16007603
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 72(Pt 6)
Protein export is important in all bacteria, and bacteria have evolved specialized export machineries to fulfil this task. InMycobacterium tuberculosis, the causative agent of tuberculosis, the general secretion pathway (Sec pathway) is conserved and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd380433133026ffe4d62af967fc240
https://pubmed.ncbi.nlm.nih.gov/27303898
https://pubmed.ncbi.nlm.nih.gov/27303898