Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Zuojia Chen"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The helper CD4+ T cell-type 17 (Th17) cells and regulatory CD4+ T cells (Tregs) are balanced through numerous molecular regulators, particularly metabolic factors, and their alteration causes immune dysregulation. Herein, we report that pero
Externí odkaz:
https://doaj.org/article/79970380836d4f668f052ac3941d16be
Autor:
Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
IL-9-producing CD4 T (Th9) cells have been implicated in allergy and tumor immunity, but how their differentiation is regulated by TGFβ is still unclear. Here the authors show that two transcription factors, DBP and E2F8, institute opposing effects
Externí odkaz:
https://doaj.org/article/bc8c2332443143d3a8f42e69ddee3045
Autor:
Jinzhun Wu, Dandan Ge, Taoling Zhong, Zuojia Chen, Ying Zhou, Lingyun Hou, Xiaoliang Lin, Jiaxu Hong, Kuai Liu, Hui Qi, Chaoying Wang, Yulin Zhou, Cheng Li, Chuan Wu, Shuiping Wu, Zuguo Liu, Qiyuan Li
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respiratory system and the re
Externí odkaz:
https://doaj.org/article/b0faee3312494851a73f0e774d98ae63
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 653-665 (2018)
A balance between Th17 and regulatory T (Treg) cells is critical for immune homeostasis and tolerance. Our previous work has shown Serum- and glucocorticoid-induced kinase 1 (SGK1) is critical for the development and function of Th17 cells. Here, we
Externí odkaz:
https://doaj.org/article/c647f96460544998b405a96b5cbe4d8b
Autor:
Lingyu Bao, Liezhen Fu, Yijun Su, Zuojia Chen, Zhaoyi Peng, Lulu Sun, Gonzalez, Frank J., Chuan Wu, Hongen Zhang, Bingyin Shi, Yun-Bo Shi
Publikováno v:
International Journal of Biological Sciences; 2024, Vol. 20 Issue 6, p2187-2201, 15p
Autor:
Yu Zhang, Trang Vu, Douglas C. Palmer, Rigel J. Kishton, Lanqi Gong, Jiao Huang, Thanh Nguyen, Zuojia Chen, Cari Smith, Ferenc Livák, Rohit Paul, Chi-Ping Day, Chuan Wu, Glenn Merlino, Kenneth Aldape, Xin-yuan Guan, Peng Jiang
Publikováno v:
Nat Med
Despite breakthroughs in cancer immunotherapy, most tumor-reactive T cells cannot persist in solid tumors due to an immunosuppressive environment. We developed Tres (tumor-resilient T cell, https://resilience.ccr.cancer.gov/), a computational model u
Autor:
Huiying Wang, Zeyu Bian, T.T. Sun, Han Chen, Y. J. Wu, Zuojia Chen, H. Ding, Q. Lian, Yinglin Xiao, Qing Yang
Publikováno v:
Journal of Materials Science & Technology. 109:254-266
In the metallic components fabricated by the emerging selective laser melting (SLM) technology, most strategies used for strengthening the materials sacrifice the ductility, leading to the so-called strength-ductility trade-off. In the present study,
Autor:
Lingyu Bao, Liezhen Fu, Yijun Su, Zuojia Chen, Zhaoyi Peng, Lulu Sun, Frank J. Gonzalez, Chuan Wu, Hongen Zhang, Bingyin Shi, Yun-Bo Shi
Publikováno v:
bioRxiv
The intestine is critical for not only processing and resorbing nutrients but also protecting the organism from the environment. These functions are mainly carried out by the epithelium, which is constantly being self-renewed. Many genes and pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f77b708e7f5e718366fb5c3dec6d195
https://europepmc.org/articles/PMC9928054/
https://europepmc.org/articles/PMC9928054/
Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme participating in diverse cellular functions. The roles of PARP-1 in the immune system, however, have not been well understood. Here we find that PARP-1 interacts with FOXP3 and indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9984d8e21cd11fd59e233dd7c12f37
https://ora.ox.ac.uk/objects/uuid:ed59ee9e-73b9-4471-ae9e-a1dbd7f9ebc8
https://ora.ox.ac.uk/objects/uuid:ed59ee9e-73b9-4471-ae9e-a1dbd7f9ebc8
Autor:
Kairong Cui, Zuojia Chen, Yaqiang Cao, Shuai Liu, Gang Ren, Gangqing Hu, Difeng Fang, Danping Wei, Chengyu Liu, Jinfang Zhu, Chuan Wu, Keji Zhao
Publikováno v:
Immunity. 56:944-958.e6