Výsledky vyhledávání - "Zuochuan Ding"

Short-term use of MyD88 inhibitor TJ-M2010-5 prevents d-galactosamine/lipopolysaccharide-induced acute liver injury in mice

Autor: Zuochuan Ding, Fengchao Jiang, Xiaoqian Zhang, Yuanyuan Zhao, Zeyang Li, Dunfeng Du, Xinqiang Wang, Yan Miao, Zhimiao Zou, Yang Yang, Jipin Jiang, Min Yang, Xue Zhang, Li-Min Zhang, Ping Zhou

Publikováno v: International immunopharmacology. 67

Excessive activation of the TLR/MyD88 signaling pathway contributes to several inflammation-related diseases. Previously, our laboratory synthesized a novel thiazaol-aminoramification MyD88 inhibitor named TJ-M2010-5. In this study, we interrogated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57445885d4b6c20e7498f3d856a4e032
https://pubmed.ncbi.nlm.nih.gov/30583234

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Human MiR-4660 regulates the expression of alanine-glyoxylate aminotransferase and may be a biomarker for idiopathic oxalosis

Autor: Xinqiang Wang, Dunfeng Du, Yuanyuan Zhao, Qianqian Li, Zuochuan Ding, Shumei Shi, Yang Yang, Xin Tu, Yan Miao, Zhimiao Zou, Xiao Yu, Jipin Jiang

Publikováno v: Clinical and experimental nephrology. 23(7)

Dysfunction of oxalate synthesis can cause calcium oxalate stone disease and inherited primary hyperoxaluria (PH) disorders. PH type I (PH1) is one of the most severe hyperoxaluria disorders, which results in urolithiasis, nephrocalcinosis, and end-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d36ad8b7144664f3c8504194e8da394
https://pubmed.ncbi.nlm.nih.gov/30852714

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A novel MyD88 inhibitor attenuates allograft rejection after heterotopic tracheal transplantation in mice

Autor: Xue Zhang, Ping Zhou, Fengchao Jiang, Sheng Chang, Zhonghua Klaus Chen, Min Yang, Yan Miao, Yang Yang, Gen Chen, Zuochuan Ding

Publikováno v: Transplant immunology. 53

Background After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c616a9d0f91000adb159c775d6701f1c
https://pubmed.ncbi.nlm.nih.gov/30472390

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Short-term MyD88 inhibition ameliorates cardiac graft rejection and promotes donor-specific hyporesponsiveness of skin grafts in mice

Autor: Shu-Yuan Li, Ping Zhou, Zuochuan Ding, Chao Li, Wentao He, Fan-Ying Meng, Zhonghua Klaus Chen, Ze-Min Fang, Li-Min Zhang

Publikováno v: Transplant international : official journal of the European Society for Organ Transplantation. 29(8)

Recognition of evolutionarily conserved ligands by Toll-like receptors (TLRs) triggers signaling cascades in innate immune cells to amplify adaptive immune responses. Nearly all TLRs require MyD88 to transduce downstream signaling. MyD88 deficiency h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e6f5528b8f255a91f922b079dd087a
https://pubmed.ncbi.nlm.nih.gov/27125343

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