Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Zuo-lin Li"'
Autor:
Qing Yin, Tao-Tao Tang, Xiao-Yu Lu, Wei-Jie Ni, Di Yin, Yi-Lin Zhang, Wei Jiang, Yue Zhang, Zuo-Lin Li, Yi Wen, Wei-Hua Gan, Ai-Qing Zhang, Lin-Li Lv, Bin Wang, Bi-Cheng Liu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Chronic kidney disease (CKD) is highly prevalent worldwide, and its global burden is substantial and growing. CKD displays a number of features of accelerated senescence. Tubular cell senescence is a common biological process that
Externí odkaz:
https://doaj.org/article/ff434889c7364d4a959255bc432359f2
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105294- (2024)
Summary: Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid and significant decrease in renal function that can arise from various etiologies, and is associated with high morbidity and mortality. The renal tubular epithelial ce
Externí odkaz:
https://doaj.org/article/683251a8a21f4f71a04f00aa1870d743
Autor:
Ke-Qi Lu, Zuo-Lin Li, Qian Zhang, Qing Yin, Yi-Lin Zhang, Wei-Jie Ni, LiangYun-Zi Jiang, Wei He, Bin Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Cell cycle-dependent protein kinase 12 (CDK12) plays a key role in a variety of carcinogenesis processes and represents a promising therapeutic target for cancer treatment. However, to date, there have been no systematic studies addressing i
Externí odkaz:
https://doaj.org/article/825f18d63ec94122a1d78db9691bc801
Publikováno v:
Kidney Diseases, Pp 1-7 (2024)
Introduction: Roxadustat, the first-in-class drug for the treatment of renal anemia, has demonstrated efficacy in renal anemia with microinflammation. Additional data are needed regarding the efficacy of roxadustat on renal anemia with systemic macro
Externí odkaz:
https://doaj.org/article/3f8c81ff1608446e8f6344cddb7a01f8
Autor:
Xing-Jian Zhang, Cong-Cong Liu, Zuo-Lin Li, Lin Ding, Yan Zhou, Dong-Jie Zhang, Yao Zhang, Shu-Ting Hou, Rui-Xia Ma
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential functional effect of Sac/Val
Externí odkaz:
https://doaj.org/article/702b5f047dc6403eb684436bc1533117
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28985- (2024)
Background: Nephronophthisis (NPHP) is a rare autosomal recessive inherited tubulointerstitial nephropathy, the most prevalent genetic cause of end-stage renal disease (ESRD) in children. Convincing evidence indicated that the overall prevalence of N
Externí odkaz:
https://doaj.org/article/4d2a7a51cd174788b9bc15663a78f831
Autor:
Zuo-Lin Li, Lin Ding, Rui-Xia Ma, Yue Zhang, Yi-Lin Zhang, Wei-Jie Ni, Tao-Tao Tang, Gui-Hua Wang, Bin Wang, Lin-Li Lv, Qiu-Li Wu, Yi Wen, Bi-Cheng Liu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-14 (2023)
Abstract The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (CTAD)]. Although the roles of
Externí odkaz:
https://doaj.org/article/db9a7f4687f6468dba20ad9d3c882cc0
Autor:
Xin Zhong, Tao-Tao Tang, An-Ran Shen, Jing-Yuan Cao, Jing Jing, Cui Wang, Xiao-Xiao Zhu, Yi Wen, Zuo-Lin Li, Bin Wang, Suo-Fu Qin, Bi-Cheng Liu, Lin-Li Lv
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Peritubular capillaries (PTCs) are closely related to renal tubules in structure and function, and both are pivotal regulators in the development and progression of acute kidney injury (AKI). However, the mechanisms that underlie the interac
Externí odkaz:
https://doaj.org/article/f23cb31e8e6c4b6c9e9ec0819fc3417a
Autor:
Zhao-Ying Ding, Tao-Tao Tang, Zuo-Lin Li, Jing-Yuan Cao, Lin-Li Lv, Yi Wen, Bin Wang, Bi-Cheng Liu
Publikováno v:
Kidney Diseases, Vol 8, Iss 3, Pp 202-212 (2022)
Introduction: Acute kidney injury (AKI) is a major public health problem worldwide. However, there is no definitive therapies to treat established AKI. In this study, we used FG-4592 to induce hypoxia inducible factor (HIF) expression in cells and th
Externí odkaz:
https://doaj.org/article/8984fc5ce1664a91942e1ebb02ce5344
Autor:
Lin-Li Lv, Cui Wang, Zuo-Lin Li, Jing-Yuan Cao, Xin Zhong, Ye Feng, Jun Chen, Tao-Tao Tang, Hai-Feng Ni, Qiu-Li Wu, Bin Wang, Hui-Yao Lan, Bi-Cheng Liu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Abstract Tubules injury and immune cell activation are the common pathogenic mechanisms in acute kidney injury (AKI). However, the exact modes of immune cell activation following tubule damage are not fully understood. Here we uncovered that the rele
Externí odkaz:
https://doaj.org/article/50af5ecc5f8d457b96f1414b614b6a16