Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Zuo-Zhong Wang"'
Publikováno v:
The Journal of Neuroscience. 29:12625-12635
RIC-3 (resistant toinhibitor ofcholinesterase) is a transmembrane protein, found in invertebrates and vertebrates, that modulates the surface expression of a variety of nicotinic acetylcholine receptors (nAChRs) in neurons and other cells. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346b5fbdaf1fafe0810105544e217999
https://doi.org/10.1523/jneurosci.1776-09.2009
https://doi.org/10.1523/jneurosci.1776-09.2009
Publikováno v:
Neuron. 60:625-641
SummaryMotoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5210c7cacbe736d4a89dbcaa5e219e
https://doi.org/10.1016/j.neuron.2008.09.025
https://doi.org/10.1016/j.neuron.2008.09.025
Publikováno v:
Channels. 1:234-237
Neurotoxins from snake venoms act as potent antagonists on the nicotinic acetylcholine receptors (nAChRs). Alpha-neurotoxins such as alpha-bungarotoxin (alpha-Btx) selectively bind to the skeletal muscle nAChRs among other subtypes, causing failure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f8ec0213e228e4b4a22e4c9791a301
https://doi.org/10.4161/chan.4909
https://doi.org/10.4161/chan.4909
Autor:
Junmei Wang, Michael A. Rudnicki, Charles H. Washabaugh, Simon C. Watkins, Lili Zhang, Yun Yao, Zuo-Zhong Wang, Marcia Ontell, Martin P. Ontell
Publikováno v:
The Journal of Neuroscience. 23:5161-5169
Myogenic regulatory factors (MRFs), muscle-specific transcription factors, are implicated in the activity-dependent regulation of nicotinic acetylcholine receptor (AChR) subunit genes. Here we show, with immunohistochemistry, Western blotting, and el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2733603129e62aad43ca57758c515a2a
https://doi.org/10.1523/jneurosci.23-12-05161.2003
https://doi.org/10.1523/jneurosci.23-12-05161.2003
Publikováno v:
Physiology & Behavior. 77:519-525
Parkinson's disease is associated with severe motor dysfunctions due to a progressive loss of dopaminergic neurons in substantia nigra. Transplantation of midbrain neurons from human fetuses to the striatum of patients provides effective treatment fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019635fdc758af0c7830a4d4cd7d149f
https://doi.org/10.1016/s0031-9384(02)00938-1
https://doi.org/10.1016/s0031-9384(02)00938-1
Publikováno v:
Nature Neuroscience. 5:963-970
Surface expression of the nicotinic acetylcholine receptor (AChR) requires the assembly of multiple subunits in the endoplasmic reticulum (ER). Little is known, however, about the mechanism by which assembled receptor pentamers are transported to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf167a67823910a2f77b3eb82c1fc5c
https://doi.org/10.1038/nn918
https://doi.org/10.1038/nn918
Autor:
Elizabeth Rothe, Nitnara Viroonchatapan, Junmei Wang, Jordan H. Chill, Yun Yao, Zuo-Zhong Wang, Avraham Samson, Jacob Anglister
Publikováno v:
Journal of Biological Chemistry. 277:12613-12621
The alpha subunit of the nicotinic acetylcholine receptor (AChR) from Torpedo electric organ and mammalian muscle contains high affinity binding sites for alpha-bungarotoxin and for autoimmune antibodies in sera of patients with myasthenia gravis. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed57a4d70f78563b8f7aed14c081617d
https://doi.org/10.1074/jbc.m108845200
https://doi.org/10.1074/jbc.m108845200
Publikováno v:
The Journal of Neuroscience. 19:1998-2007
Although the metabolic half-life of muscle endplate acetylcholine receptor (AChR) changes during development and after denervation in the adult, little is known about the molecular mechanisms that influence receptor stability. We have investigated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77273c84c6b73007d6a7df280112b7c9
https://doi.org/10.1523/jneurosci.19-06-01998.1999
https://doi.org/10.1523/jneurosci.19-06-01998.1999
Publikováno v:
Journal of Biological Chemistry. 271:27575-27584
To investigate the mechanism of assembly of the mouse muscle acetylcholine receptor, we have expressed truncated N-terminal fragments of the α and δ subunits in COS cells and have examined their ability to fold, to associate into heterodimers, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c14f0790c85774c2a87e54f2c843ac
https://doi.org/10.1074/jbc.271.44.27575
https://doi.org/10.1074/jbc.271.44.27575
Publikováno v:
The Journal of biological chemistry. 285(36)
Agrin isoforms with different bioactivities are synthesized by the nerve and the muscle. Neural agrin containing an 8-amino acid insert (z8) introduced by alternative splicing is the active form that induces synaptic differentiation at the neuromuscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f248f1a69c9801fc7a6593cff76ef0
https://pubmed.ncbi.nlm.nih.gov/20566625
https://pubmed.ncbi.nlm.nih.gov/20566625