Glycogen synthase kinase 3 inactivation drives T-bet-mediated downregulation of co-receptor PD-1 to enhance CD8+ cytolytic T cell responses

Autor: Taylor, A, Harker, JA, Chanthong, K, Stevenson, PG, Zuniga, EI, Rudd, CE

Despite the importance of the co-receptor PD-1 in T cell immunity, the upstream signaling pathway that regulates PD-1 expression has not been defined. Glycogen synthase kinase 3 (GSK-3, isoforms α and β) is a serine-threonine kinase implicated in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5afae04e1ecd7f15727ee0464ccbc2f6
http://hdl.handle.net/10044/1/32989

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The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.

Autor: Hernandez JE; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Llorente C; https://ror.org/0168r3w48 Department of Medicine, University of California San Diego, La Jolla, CA, USA., Ma S; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Miyamoto KT; https://ror.org/0168r3w48 Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Sinha S; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Steele S; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Xiao Z; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Lai CJ; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Zuniga EI; https://ror.org/0168r3w48 Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Ghosh P; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; https://ror.org/0168r3w48 Department of Medicine, University of California San Diego, La Jolla, CA, USA., Schnabl B; https://ror.org/0168r3w48 Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Huang WJM; https://ror.org/0168r3w48 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA wendyjmhuang@health.ucsd.edu.

Publikováno v: Life science alliance [Life Sci Alliance] 2023 Sep 04; Vol. 6 (11). Date of Electronic Publication: 2023 Sep 04 (Print Publication: 2023).