Zobrazeno 1 - 10
of 157
pro vyhledávání: '"ZunFu Ke"'
Autor:
Mei Song, Shuting Huang, Xiaoxue Wu, Ziyi Zhao, Xiaoting Liu, Chong Wu, Mengru Wang, Jialing Gao, Zunfu Ke, Xiaojing Ma, Weiling He
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103349- (2024)
Chemoresistance remains a principal culprit for the treatment failure in colorectal cancer (CRC), especially for patients with recurrent or metastatic disease. Deciphering the molecular basis of chemoresistance may lead to novel therapeutic strategie
Externí odkaz:
https://doaj.org/article/c9db8d125c5d4975853e2f412315e336
Autor:
Lei Sun, Arabella H. Wan, Shijia Yan, Ruonian Liu, Jiarui Li, Zhuolong Zhou, Ruirui Wu, Dongshi Chen, Xianzhang Bu, Jingxing Ou, Kai Li, Xiongbin Lu, Guohui Wan, Zunfu Ke
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 223-240 (2024)
Lenvatinib, a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer, facing limitations due to drug resistance. Here, we applied a multidimensional, high-throughput screening
Externí odkaz:
https://doaj.org/article/6fd491e1a58a4961a1629f26aa3391ae
Autor:
Qinru Zhan, Bixia Liu, Xiaohua Situ, Yuting Luo, Tongze Fu, Yanxia Wang, Zhongpeng Xie, Lijuan Ren, Ying Zhu, Weiling He, Zunfu Ke
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-23 (2023)
Abstract Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment
Externí odkaz:
https://doaj.org/article/d92d39a63d8645f5ad4d6bd56213d1c2
Autor:
Baohong Luo, Yu Sun, Qinru Zhan, Yuting Luo, Yu Chen, Tongze Fu, Tiantian Yang, Lijuan Ren, Zhongpeng Xie, Xiaohua Situ, Bixia Liu, Kejing Tang, Zunfu Ke
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Background T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) is an immune checkpoint molecule that suppresses CD8+ T‐cell function in cancer. However, the expression profile and functional signific
Externí odkaz:
https://doaj.org/article/9f05ad792a4943bc9580a5071deb2e87
Autor:
Yi‐Long Wu, Shun Lu, Qinghua Zhou, Li Zhang, Ying Cheng, Jie Wang, Buhai Wang, Chengping Hu, Lizhu Lin, Wenzhao Zhong, Yong Song, Nong Yang, Xiaorong Dong, Jian Zhao, Haihong Yang, Hui Guo, Xiaolong Yan, Hongxu Liu, Rui Ma, Jie Lin, Siyang Liu, Chun Chen, Lifeng Wang, Chengzhi Zhou, Ming Zhou, Fang Wu, Xue‐Ning Yang, Yingying Du, Yu Yao, Yang Shao, Shaodong Hong, Jiuwei Cui, Xueping Quan, Rongrong Chen, Jiayan Wu, Jiatao Zhang, Jianya Zhou, Binchao Wang, Chao Cheng, Huijuan Wang, Jingjing Liu, Lin Wu, Yan Huang, Yukun Kuang, Yongchang Zhang, Jia Hu, Jinji Yang, Weineng Feng, Wenmei Su, Yun Fan, Fan Yang, Ming Chen, Kejing Tang, Yi Pan, Peng Shen, Anwen Liu, Haibo Zhang, Wenhua Liang, Qing Zhou, Zhiyong Ma, Xiuyu Cai, Hui Liu, Longfei Chen, Shaokun Chuai, Jianzhen Shan, Yanfang Zheng, Changxuan You, Xiaoxia Zhu, Li Li, Tongmei Zhang, Haiyan Tu, Wurong Lin, Xuchao Zhang, Penghui Zhou, Zunfu Ke, Huiying Liang
Publikováno v:
Medicine Advances, Vol 1, Iss 1, Pp 3-13 (2023)
Abstract Stage III non‐small cell lung cancer (NSCLC) encompasses a group of diseases with high heterogeneity. Such patients should actively receive comprehensive treatments. It is imperative for all stage III NSCLC patients to receive consultation
Externí odkaz:
https://doaj.org/article/628a61c2e0b7401888cbceb96adb32ce
Autor:
Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Dai, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 5, Pp 2268-2279 (2022)
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-compl
Externí odkaz:
https://doaj.org/article/283910d86bdf442eac0cd9da6b6292df
Autor:
Binfeng Chen, Baokui Ye, Mengyuan Li, Shuyi Wang, Jin Li, Yimei Lai, Niansheng Yang, Zunfu Ke, Hui Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tissue-resident memory T cells (TRM cells) have been shown to play an instrumental role in providing local immune responses for pathogen clearance in barrier tissues. However, their contribution to inflammatory bowel diseases (IBDs) and the underlyin
Externí odkaz:
https://doaj.org/article/dc8632672c1045a2850ed9e8dbcf4b63
Autor:
Huan Yang, Lili Chen, Zhiqiang Cheng, Minglei Yang, Jianbo Wang, Chenghao Lin, Yuefeng Wang, Leilei Huang, Yangshan Chen, Sui Peng, Zunfu Ke, Weizhong Li
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Targeted therapy and immunotherapy put forward higher demands for accurate lung cancer classification, as well as benign versus malignant disease discrimination. Digital whole slide images (WSIs) witnessed the transition from trad
Externí odkaz:
https://doaj.org/article/c926df78fcd5460bacc79e0277f19284
Autor:
Xiaoshi Ma, Jinan Guo, Kaisheng Liu, Lipeng Chen, Dale Liu, Shaowei Dong, Jinquan Xia, Qiaoyun Long, Yongjian Yue, Pan Zhao, Fengyan Hu, Zhangang Xiao, Xinghua Pan, Kefeng Xiao, Zhiqiang Cheng, Zunfu Ke, Zhe-Sheng Chen, Chang Zou
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-17 (2020)
Abstract Background The highly intra-tumoral heterogeneity and complex cell origination of prostate cancer greatly limits the utility of traditional bulk RNA sequencing in finding better biomarker for disease diagnosis and stratification. Tissue spec
Externí odkaz:
https://doaj.org/article/f39e13bb945448659f7bdaf8002b4d1e
Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy
Autor:
Xiaoming Zhong, Hangtian Zhang, Ying Zhu, Yuqing Liang, Zhuolin Yuan, Jiachen Li, Jing Li, Xin Li, Yifan Jia, Tian He, Jiangyuan Zhu, Yu Sun, Wengting Jiang, Hui Zhang, Cheng Wang, Zunfu Ke
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract Cancer metastasis is the leading cause of cancer-related death. Circulating tumor cells (CTCs) are shed into the bloodstream from either primary or metastatic tumors during an intermediate stage of metastasis. In recent years, immunotherapy
Externí odkaz:
https://doaj.org/article/05f3f0fe66cc47918d2ea47156760dee