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of 3
pro vyhledávání: '"Zulfiye Yesim Turhan"'
Autor:
Farah El Mohtadi, Richard d’Arcy, Xiaoye Yang, Zulfiye Yesim Turhan, Aws Alshamsan, Nicola Tirelli
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4583 (2019)
We present the evaluation of a sulfoxide-based polymer (poly(propylene sulfoxide), PPSO) as a potential ‘stealth’ macromolecule, and at the same time as a pharmacologically active (anti-inflammatory/anti-oxidant) material. The combination of thes
Externí odkaz:
https://doaj.org/article/9e2dabe0a1ae462d85a233bc2bd7f966
Autor:
Richard d’Arcy, Farah El Mohtadi, Nora Francini, Carlisle R. DeJulius, Hyunmoon Back, Arianna Gennari, Mike Geven, Maria Lopez-Cavestany, Zulfiye Yesim Turhan, Fang Yu, Jong Bong Lee, Michael R. King, Leonid Kagan, Craig L. Duvall, Nicola Tirelli
Publikováno v:
D'Arcy, R, El Mohtadi, F, Francini, N, Dejulius, C R, Back, H, Gennari, A, Geven, M, Lopez-Cavestany, M, Turhan, Z Y, Yu, F, Lee, J B, King, M R, Kagan, L, Duvall, C L & Tirelli, N 2022, ' A Reactive Oxygen Species-Scavenging Stealth' Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors ', Journal of the American Chemical Society, vol. 144, no. 46, pp. 21304-21317 . https://doi.org/10.1021/jacs.2c09232
This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but ha
Autor:
Farah El-Mohtadi, Richard d'Arcy, Nicola Tirelli, Zulfiye Yesim Turhan, Mike A. Geven, Aws Alshamsan
Publikováno v:
European Polymer Journal. 149:110387
The introduction of low-oxidation-state sulfur atoms is a popular strategy to provide macromolecules with responsivity to oxidizing conditions, which in turn may confer them specific functionality (e.g. bioactivity or improved targeting). Indeed, rea