HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

Autor: Giorgio Mangino, Zulema A Percario, Gianna Fiorucci, Gabriele Vaccari, Filippo Acconcia, Cristiano Chiarabelli, Stefano Leone, Alessia Noto, Florian A Horenkamp, Santiago Manrique, Giovanna Romeo, Fabio Polticelli, Matthias Geyer, Elisabetta Affabris

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e22982 (2011)

BackgroundHIV-1 Nef is a virulence factor that plays multiple roles during HIV replication. Recently, it has been described that Nef intersects the CD40 signalling in macrophages, leading to modification in the pattern of secreted factors that appear

Externí odkaz: https://doaj.org/article/34fcc4205ca1453aabeae154c7d33f49

SARS-CoV-2 Evasion of the Interferon System: Can We Restore Its Effectiveness?

Autor: Alessandra Sacchi, Flavia Giannessi, Andrea Sabatini, Zulema Antonia Percario, Elisabetta Affabris

Type I and III Interferons (IFNs) are the first lines of defense in microbial infections. They critically block early animal virus infection, replication, spread, and tropism to promote the adaptive immune response. Type I IFNs induce a systemic resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab3619c89bb197092f2e2ea76e5002c
https://hdl.handle.net/11590/441432

HIV-1 Nef Protein Affects Cytokine and Extracellular Vesicles Production in the GEN2.2 Plasmacytoid Dendritic Cell Line

Autor: Alessandra Aiello, Flavia Giannessi, Zulema Antonia Percario, Katia Fecchi, Claudia Arenaccio, Stefano Leone, Maria Carollo, Elisabetta D’Aversa, Laurence Chaperot, Roberto Gambari, Massimo Sargiacomo, Elisabetta Affabris

Publikováno v: Viruses; Volume 14; Issue 1; Pages: 74
Viruses
Viruses, Vol 14, Iss 74, p 74 (2022)
Viruses, 2022, 14 (1), pp.74. ⟨10.3390/v14010074⟩

International audience; Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset specialized in type I interferon production, whose role in Human Immunodeficiency Virus (HIV) infection and pathogenesis is complex and not yet well define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce20bc0dae3e96a77cfc8e2cb219f3a

Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3

Autor: Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology

Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T-4, but also T-3, act non-genomically through mechanisms that involve a plasma membrane receptor alpha v beta 3 integrin, a co-rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aa667d665980e431230e15f11ef447
https://www.frontiersin.org/articles/10.3389/fcell.2021.651492/full

Antioxidant and biological activities of hydroxytyrosol and homovanillic alcohol obtained from olive mill wastewaters of extra-virgin olive oil production

Autor: Luciano Saso, Fabio Gionfra, Ludovica Primitivo, Martina De Angelis, Veronica Bonfantini, Sandra Incerpi, Zulema A. Percario, Jens Z. Pedersen, Simonetta Maria Bullitta, Roberto Antonioletti, Alessandra Ricelli

Publikováno v: Journal of agricultural and food chemistry 68 (2020): 15428–15439. doi:10.1021/acs.jafc.0c05230
info:cnr-pdr/source/autori:Ricelli A., Gionfra F., Percario Z., De Angelis M., Primitivo L., Bonfantini V., Antonioletti R., Bullitta S.M., Saso L., Incerpi S., Pedersen J.Z./titolo:Antioxidant and biological activities of Hydroxytyrosol and Homovanillic Alcohol obtained from olive mill wastewaters of Extra-Virgin Olive Oil Production./doi:10.1021%2Facs.jafc.0c05230/rivista:Journal of agricultural and food chemistry/anno:2020/pagina_da:15428/pagina_a:15439/intervallo_pagine:15428–15439/volume:68

Some constituents of the Mediterranean diet, such as extra-virgin olive oil (EVOO) contain substances such as hydroxytyrosol (HT) and its metabolite homovanillic alcohol (HA). HT has aroused much interest due to its antioxidant activity as a radical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb1dae4b4226dc9cd15fe9dbb0675b8
http://hdl.handle.net/11573/1466407