Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zuhal, Dincer"'
Autor:
Marc Bigaud, Zuhal Dincer, Birgit Bollbuck, Janet Dawson, Nicolau Beckmann, Christian Beerli, Gina Fishli-Cavelti, Michaela Nahler, Daniela Angst, Philipp Janser, Heike Otto, Elisabeth Rosner, Rene Hersperger, Christian Bruns, Jean Quancard
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168252 (2016)
Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known to reduce vascular barrier integrity with still unclear pathophysiological consequences. Th
Externí odkaz:
https://doaj.org/article/d21025381568439f81e9c5673c237ad7
Publikováno v:
Journal of Toxicologic Pathology
This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04680af93ae5cb03226a37eac5c8c3fd
http://europepmc.org/articles/PMC7008203
http://europepmc.org/articles/PMC7008203
Autor:
Andréanne Lortie, Keith Jones, Helen Prior, Samuel S. Chuang, Michael Schmitt, Lars Friis Mikkelsen, Steven Van Cruchten, Sven Jäckel, Björn Jacobsen, Noel Downes, Sofiene Mhedhbi, Jacqueline Kinyamu-Akunda, Joanna Harding, Susanne Mohr, Zuhal Dincer, Rostam Namdari
Publikováno v:
Regulatory toxicology and pharmacology
In drug development, nonclinical safety assessment is pivotal for human risk assessment and support of clinical development. Selecting the relevant/appropriate animal species for toxicity testing increases the likelihood of detecting potential effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2a77a27d35632ac02a82b8e120e3ae
https://repository.uantwerpen.be/docstore/d:irua:9299
https://repository.uantwerpen.be/docstore/d:irua:9299
Autor:
Zuhal Dincer, Jagannatha Mysore, Frank J. Geoly, Maria Cristina De Vera Mudry, Cecilia Parrula, Kuno Wuersch
Publikováno v:
Toxicologic pathology. 48(8)
In nonrodent toxicity studies that are usually conducted in cynomolgus monkeys or beagle dogs, the added value of examining all tissues from all dose groups (current practice) versus all tissues in only control and high-dose groups and target tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b182c9bdec63694ea3e5578161d362
https://pubmed.ncbi.nlm.nih.gov/33252033
https://pubmed.ncbi.nlm.nih.gov/33252033
Publikováno v:
Toxicologic pathology. 46(2)
Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86baa5d11fb7c25c3e3df3491e0a07a9
https://pubmed.ncbi.nlm.nih.gov/29471777
https://pubmed.ncbi.nlm.nih.gov/29471777
Autor:
Daniela Angst, Nicolau Beckmann, Christian Bruns, Philipp Janser, Heike Otto, Jean Quancard, Marc Bigaud, Elisabeth Rosner, Birgit Bollbuck, Gina Fishli-Cavelti, Christian Beerli, Zuhal Dincer, Rene Hersperger, Michaela Nahler, Janet Dawson
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168252 (2016)
PLoS ONE
PLoS ONE
Rational Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known to reduce vascular barrier integrity with still unclear pathophysiological consequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9efb32950a8fc714d76e94ffb92b371
http://europepmc.org/articles/PMC5179015?pdf=render
http://europepmc.org/articles/PMC5179015?pdf=render
Publikováno v:
Toxicologic pathology. 44(3)
Minipigs are increasingly being used as an alternative to dog or monkey in nonclinical safety testing of pharmaceuticals since they share similar anatomical and physiological characteristics to humans. Integrative assessment of pharmacodynamic and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfa742f582e52cf3b7d530136f0d0d8
https://pubmed.ncbi.nlm.nih.gov/26698323
https://pubmed.ncbi.nlm.nih.gov/26698323
Publikováno v:
British Journal of Nutrition. 79:329-331
Ammonium tetrathiomolybdate (TTM) is the treatment of choice for chronic Cu poisoning in sheep and is recommended in Wilson's disease. However, the long-term effects have not been fully evaluated and some evidence questions the long-term safety of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc3a78e3c840f9be1c530576cec6162
https://doi.org/10.1079/bjn19980056
https://doi.org/10.1079/bjn19980056
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 57(5-6)
DNA vaccination involves the direct injection of genes coding for specific antigenic proteins. One technique known as particle-mediated epidermal delivery (PMED) is a practical approach for epidermal delivery and provides a strong immune response. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73aec4c2fd7571ba61f95de29e6c18a8
https://pubmed.ncbi.nlm.nih.gov/16713213
https://pubmed.ncbi.nlm.nih.gov/16713213
Autor:
Heiko, Schadt, Zuhal, Dincer, Marianne, Schwald, Audrey, Dietz, David, Ledieu, Andre, Cordier, Maria, Papoutsi, Ursula, Junker Walker, Fiona, Spence, Salah-Dine, Chibout, Armin, Wolf, Francois, Pognan
Publikováno v:
In Toxicology Letters 28 August 2013 221 Supplement:S172-S172