Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zuguang Xue"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world with high morbidity and mortality. Identifying specific molecular markers that can predict HCC prognosis is extremely important. MELK has been reported
Externí odkaz:
https://doaj.org/article/1705056f062e4dcdbdbf856194b7d4c3
Autor:
Hong Zhang, Yafei Guo, Xiaodong Zhang, Zongwei Guo, Laura B. Uwituze, Zuguang Xue, Donghai Lin, Hang Wang, Ting Song, Fangkui Yin, Ziqian Wang, Zhichao Zhang, Hao Pan
Publikováno v:
Leukemia. 35(10)
Herein, we screened a novel inhibitor of the Hsp70-Bim protein-protein interaction (PPI), S1g-2, from a Bcl-2 inhibitor library; this compound specifically disrupted the Hsp70-Bim PPI by direct binding to an unknown site adjacent to that of an allost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f948dab84b413a23dda2eda59f9d71c
https://pubmed.ncbi.nlm.nih.gov/34007045
https://pubmed.ncbi.nlm.nih.gov/34007045
Publikováno v:
Brain Research. 1657:87-94
Recent study has suggested that estrogen replacement therapy (ERT) can decrease the risk of the development of Alzheimer's disease (AD), and phytoestrogen has been proposed as a potential alternative to ERT. In this study, we investigated the protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a3252a75af3d8684299d15a997bf1a
https://doi.org/10.1016/j.brainres.2016.11.023
https://doi.org/10.1016/j.brainres.2016.11.023
Publikováno v:
European Journal of Pharmaceutical Sciences. 142:105105
Deepening understanding of how Bcl-2 family proteins protect cancer cells from apoptosis has driven the development of 'BH3 mimetic' drugs that target various anti-apoptotic Bcl-2-like proteins by mimicking their natural inhibitors, the BH3-only prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263903985a320e318ff64f6590f07c7c
https://doi.org/10.1016/j.ejps.2019.105105
https://doi.org/10.1016/j.ejps.2019.105105
Publikováno v:
Brain research. 1657
Recent study has suggested that estrogen replacement therapy (ERT) can decrease the risk of the development of Alzheimer's disease (AD), and phytoestrogen has been proposed as a potential alternative to ERT. In this study, we investigated the protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c626f76d59941fa257aaf198c04a1fe
https://pubmed.ncbi.nlm.nih.gov/27923632
https://pubmed.ncbi.nlm.nih.gov/27923632
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 67(7)
Most of leukemia exhibits inherent overexpressed Bcl-2-like proteins. Small molecule S1 is a BH3 mimetic discovered by our previous studies. The aim of this study is to dissect the details of apoptosis signaling induced by S1 in acute myeloid leukaem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73c3cf699e05c805eee3921bd826879
https://pubmed.ncbi.nlm.nih.gov/23706691
https://pubmed.ncbi.nlm.nih.gov/23706691
Publikováno v:
Basicclinical pharmacologytoxicology. 113(3)
Small molecule S1 is a pan-BH3 mimetic that can bind antiapoptotic Bcl-2, Bcl-xL and Mcl-1 proteins. Herein, different Bcl-2 member expression cancer cell lines (NCI-H345, MCF-7, SMMC-7721 and Hela) and cells deficient in Bax and/or Bak by shRNA were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4304c0c324101ec79755191e6d4b817f
https://pubmed.ncbi.nlm.nih.gov/23557083
https://pubmed.ncbi.nlm.nih.gov/23557083