Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Zufeng Guo"'
Autor:
Kunling Song, Longbin Zhang, Xian Fu, Linfeng Li, Gaolin Zhu, Mingjun Wu, Wei Zhang, Jia He, Sanyong Zhu, Yongjun Dang, Jun-Yan Liu, Chang Chen, Zufeng Guo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Solute carrier (SLC) transport proteins play a crucial role in maintaining cellular nutrient and metabolite homeostasis and are implicated in various human diseases, making them potential targets for therapeutic interventions. However,
Externí odkaz:
https://doaj.org/article/8e41ec9585a24c07afaabe531d922f46
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9073dd58cc6947e998f8064b6fbc3a86
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial attention as promising therapeutic targets due to their fundamental biologi
Externí odkaz:
https://doaj.org/article/ed912e79fd1746f69e100e9295b87c66
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Altered tumor metabolism is a hallmark of cancer and targeting tumor metabolism has been considered as an attractive strategy for cancer therapy. Prostaglandin Reductase 1 (PTGR1) is a rate-limiting enzyme involved in the arachidonic acid metabolism
Externí odkaz:
https://doaj.org/article/81c54f65eb3f4ef39231919bfead87ef
Autor:
Shuang Zhao, Yi He, Feiyu Gao, Yue Wei, Jiawei Zhang, Mengxiao Chen, Yunyun Gao, Yuan Zhang, Jun-Yan Liu, Zufeng Guo, Zhenghua Li, Shenyou Nie
Publikováno v:
Chemical Communications. 59:3099-3102
Highly efficient synthesis of diverse 2,2-disubstituted 3-methyleneindoline derivatives through a one-pot base-promoted post-Ugi 5-exo-dig “Conia-ene”-type cyclization has been disclosed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40d4f5df8182dc1ad679e9230208bb2a
https://doi.org/10.1039/d2cc06281j
https://doi.org/10.1039/d2cc06281j
Autor:
Wukun Liu, Sam Y. Hong, Zhaoli Sun, Brett R. Ullman, Jingxin Wang, Zlatina Tarmakova, Shridhar Bhat, Zufeng Guo, Ville O. Paavilainen, Manisha Das, Brandon J. Peiffer, Wei Li, Shahid Rehan, Imogen R. Coe, Cordelia Schiene-Fischer, Hanjing Peng, Gunter Fischer, Jun O. Liu, Chung Ming Tse
Publikováno v:
Nature chemistry
Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode of action—they form binary complexes with FKBP through a shared FKBP-binding domain before forming ternary complexes with their respective targets, mTOR and calcineurin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115b2634250a45b22adaa3931b6274f0
https://doi.org/10.32920/21979724
https://doi.org/10.32920/21979724
Autor:
Zufeng Guo, Hanjing Peng, Brett R. Ullman, Yuefan Wang, Jun O. Liu, Kana Yamamoto, Sam Y. Hong
Publikováno v:
Chemical Science
Rapadocin is a novel rapamycin-inspired polyketide–tetrapeptide hybrid macrocycle that possesses highly potent and isoform-specific inhibitory activity against the human equilibrative nucleoside transporter 1 (hENT1). Rapadocin contains an epimeriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ab6fc069838bbfaea235418a5c0ec2
https://doi.org/10.1039/d1sc02295d
https://doi.org/10.1039/d1sc02295d
Autor:
Zufeng Guo, Jun O. Liu, Jason W. Locasale, Maria V. Liberti, Katherine R. Singleton, Kris C. Wood, Ziwei Dai, Vijyendra Ramesh, Annamarie E. Allen
Publikováno v:
J Biol Chem
Aerobic glycolysis or the Warburg effect (WE) is characterized by increased glucose uptake and incomplete oxidation to lactate. Although the WE is ubiquitous, its biological role remains controversial, and whether glucose metabolism is functionally d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df50b9176737e7bcf5a0cb78803250e
https://doi.org/10.1074/jbc.ra119.010903
https://doi.org/10.1074/jbc.ra119.010903
Autor:
Zhiqiang Cheng, Ruo jing Li, A. V.Subba Rao, Hanjing Peng, Yuefan Wang, Yingjun Li, Zufeng Guo, Saraswati Sukumar, Gunter Fischer, Jun O. Liu, Yongmei Xie, Jason W. Locasale, Sam Y. Hong, Jingxin Wang, Wukun Liu, Cordelia Schiene-Fischer, Preethi Korangath, Maria V. Liberti, Heng Zhu, Xue Ying
Publikováno v:
Angew Chem Int Ed Engl
Glucose transporters play an essential role in cancer cell proliferation and survival and have been pursued as promising cancer drug targets. Using microarrays of a library of new macrocycles known as rapafucins, which were inspired by the natural pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d61f7071986432729290ebc47b27757
https://doi.org/10.1002/anie.201905578
https://doi.org/10.1002/anie.201905578
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-2 (2020)
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-2 (2020)
Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a685d78d34ad48d07a746c28a31a9aca
http://europepmc.org/articles/PMC7289795
http://europepmc.org/articles/PMC7289795