High Throughput Screening of a GlaxoSmithKline Protein Kinase Inhibitor Set Identifies an Inhibitor of Human Cytomegalovirus Replication that Prevents CREB and Histone H3 Post-Translational Modification

Autor: Khan, AS, Murray, MJ, Ho, CMK, Zuercher, WJ, Reeves, MB, Strang, BL

To identify new compounds with anti-human cytomegalovirus (HCMV) activity and new anti-HCMV targets, we developed a high throughput strategy to screen a GlaxoSmithKline (GSK) Published Kinase Inhibitor Set (PKIS). This collection contains a range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e242e8e09b3ad1ad36b2f84a16b7f1f5
https://openaccess.sgul.ac.uk/id/eprint/108546/7/jgv.0.000713.pdf

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Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline.

Autor: Nandakumar M; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Ollodart A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States., Fleck N; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States., Kapadia NR; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Frando A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States., Boradia V; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States., Smith JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Chen J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States., Zuercher WJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Grundner C; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington 98109, United States.; Department of Pediatrics, University of Washington, Seattle, Washington 98195, United States.; Department of Global Health, University of Washington, Seattle, Washington 98105, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14724-14734. Date of Electronic Publication: 2023 Oct 23.

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.

Autor: Carling PJ; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.; Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UK., Ryan BJ; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., McGuinness W; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Kataria S; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.; Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UK., Humble SW; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.; Inherited Neurodegenerative Diseases Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD USA., Milde S; ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Cambridge., Duce JA; ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Cambridge., Kapadia N; Structural Genomics Consortium, UNC, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., Zuercher WJ; Structural Genomics Consortium, UNC, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., Davis JB; Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UK., Di Daniel E; Oxford Drug Discovery Institute, Target Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Oxford, UK., Wade-Martins R; Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK.

Publikováno v: Autophagy [Autophagy] 2023 Feb; Vol. 19 (2), pp. 692-705. Date of Electronic Publication: 2022 Jul 25.