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In vitro and in vivo optimization of impaction allografting by demineralization and addition of rh-OP-1

Autor: N Gurav, Sanjukta Deb, Amit Bhalla, Eleftherios Tsiridis, Zubier Ali, Lucy DiSilvio, Manolis Heliotis

Publikováno v: Journal of Orthopaedic Research. 25:1425-1437

Impaction allografting is a bone tissue engineering technique currently used in lower limb reconstruction orthopedic surgery. Our hypothesis was that biological optimization can be achieved by demineralization and addition of osteogenic protein-1 (OP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e38d578665929194f5c0d6fab3bf38b
https://doi.org/10.1002/jor.20387

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Enhancing the osteoinductive properties of hydroxyapatite by the addition of human mesenchymal stem cells, and recombinant human osteogenic protein-1 (BMP-7) in vitro

Autor: Lucy DiSilvio, Manolis Heliotis, Zubier Ali, Eleftherios Tsiridis, N Gurav, Sanjukta Deb, Amit Bhalla

Publikováno v: Injury. 37:S25-S32

Hydroxyapatite (HA) has been widely used as a bone graft substitute. In this study, we investigated whether the addition of osteogenic protein-1 (OP-1) further enhanced the weak osteoinductive properties of hydroxyapatite when loaded with human mesen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d6af4150d7cbeb9ec6645906cabfb7
https://doi.org/10.1016/j.injury.2006.08.021

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In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1

Autor: Amit Bhalla, Eleftherios Tsiridis, Zakareya Gamie, Manolis Heliotis, N Gurav, Sanjukta Deb, Lucy DiSilvio, Zubier Ali

Publikováno v: Expert opinion on biological therapy. 9(1)

Allografting is currently used in lower limb reconstruction surgery. Demineralised bone matrix (DBM) is more osteoinductive compared with allografts but lacks mechanical strength. Osteogenic protein-1 (OP-1) can improve the osteoinductivity of the al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b458af8e987311e0f7d04c1eee24037
https://pubmed.ncbi.nlm.nih.gov/19063689

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