Concerted transformation of a hyper-paused transcription complex and its reinforcing protein.

Autor: Zuber PK; Biochemistry IV-Biophysical Chemistry, Universität Bayreuth, Bayreuth, Germany.; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK., Said N; Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Berlin, Germany., Hilal T; Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Berlin, Germany.; Research Center of Electron Microscopy and Core Facility BioSupraMol, Freie Universität Berlin, Berlin, Germany., Wang B; Department of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, OH, USA., Loll B; Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Berlin, Germany., González-Higueras J; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; ANID, Millennium Science Initiative Program, Millennium Institute for Integrative Biology, Santiago, Chile., Ramírez-Sarmiento CA; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; ANID, Millennium Science Initiative Program, Millennium Institute for Integrative Biology, Santiago, Chile., Belogurov GA; Department of Life Technologies, University of Turku, Turku, Finland., Artsimovitch I; Department of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, OH, USA. artsimovitch.1@osu.edu., Wahl MC; Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Berlin, Germany. markus.wahl@fu-berlin.de.; Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, Berlin, Germany. markus.wahl@fu-berlin.de., Knauer SH; Biochemistry IV-Biophysical Chemistry, Universität Bayreuth, Bayreuth, Germany. Stefan.knauer@bms.com.; Bristol-Myers Squibb GmbH & Co. KGaA, Munich, Germany. Stefan.knauer@bms.com.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 08; Vol. 15 (1), pp. 3040. Date of Electronic Publication: 2024 Apr 08.

Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex.

Autor: Washburn RS; Department of Microbiology & Immunology, Columbia University Medical Center, New York, NY 10032, USA., Zuber PK; Biochemistry IV - Biopolymers, University of Bayreuth, 95447 Bayreuth, Germany., Sun M; Department of Biological Sciences, Columbia University, New York, NY 10027, USA., Hashem Y; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA., Shen B; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA., Li W; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA., Harvey S; University of Michigan, Ann Arbor, MI 48109, USA., Acosta Reyes FJ; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA., Gottesman ME; Department of Microbiology & Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: meg8@cumc.columbia.edu., Knauer SH; Biochemistry IV - Biopolymers, University of Bayreuth, 95447 Bayreuth, Germany. Electronic address: stefan.knauer@uni-bayreuth.de., Frank J; Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: jf2192@cumc.columbia.edu.

Publikováno v: IScience [iScience] 2020 Aug 21; Vol. 23 (8), pp. 101352. Date of Electronic Publication: 2020 Jul 09.

Reversible fold-switching controls the functional cycle of the antitermination factor RfaH.

Autor: Zuber PK; Lehrstuhl Biopolymere, Universität Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany., Schweimer K; Lehrstuhl Biopolymere, Universität Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany., Rösch P; Lehrstuhl Biopolymere, Universität Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany.; Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany., Artsimovitch I; Department of Microbiology, The Ohio State University, Columbus, OH, 43210, USA. artsimovitch.1@osu.edu.; The Center for RNA Biology, The Ohio State University, Columbus, OH, 43210, USA. artsimovitch.1@osu.edu., Knauer SH; Lehrstuhl Biopolymere, Universität Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany. stefan.knauer@uni-bayreuth.de.

Publikováno v: Nature communications [Nat Commun] 2019 Feb 11; Vol. 10 (1), pp. 702. Date of Electronic Publication: 2019 Feb 11.

The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand.

Autor: Zuber PK; Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Bayreuth, Germany., Artsimovitch I; Department of Microbiology, The Ohio State University, Columbus, United States.; The Center for RNA Biology, The Ohio State University, Columbus, United States., NandyMazumdar M; Department of Microbiology, The Ohio State University, Columbus, United States.; The Center for RNA Biology, The Ohio State University, Columbus, United States., Liu Z; Department of Microbiology, The Ohio State University, Columbus, United States.; The Center for RNA Biology, The Ohio State University, Columbus, United States., Nedialkov Y; Department of Microbiology, The Ohio State University, Columbus, United States.; The Center for RNA Biology, The Ohio State University, Columbus, United States., Schweimer K; Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Bayreuth, Germany., Rösch P; Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Bayreuth, Germany., Knauer SH; Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Bayreuth, Germany.

Publikováno v: ELife [Elife] 2018 May 09; Vol. 7. Date of Electronic Publication: 2018 May 09.

AlphaFold predictions of fold-switched conformations are driven by structure memorization.

Autor: Chakravarty, Devlina, Schafer, Joseph W., Chen, Ethan A., Thole, Joseph F., Ronish, Leslie A., Lee, Myeongsang, Porter, Lauren L.

Publikováno v: Nature Communications; 8/24/2024, Vol. 15 Issue 1, p1-13, 13p