Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Zuanning Yuan"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The eukaryotic polymerase α (Pol α) synthesizes an RNA-DNA hybrid primer of 20–30 nucleotides. Pol α is composed of Pol1, Pol12, Primase 1 (Pri1), and Pri2. Pol1 and Pri1 contain the DNA polymerase and RNA primase activities, respective
Externí odkaz:
https://doaj.org/article/4895763778d24baebc55b930840bbe07
Autor:
Minge Du, Zuanning Yuan, Glenn T. Werneburg, Nadine S. Henderson, Hemil Chauhan, Amanda Kovach, Gongpu Zhao, Jessica Johl, Huilin Li, David G. Thanassi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Escherichia coli form pili structures in order to initiate infection of the urinary tract. Here, Thanassi et al., have solved the structures of pili assembly intermediates and provided insights into their biogenesis and assembly.
Externí odkaz:
https://doaj.org/article/8a64b8abfd8d41f0a8749b5b52ff307e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
DNA polymerase epsilon (Pol ε) is responsible for leading strand synthesis during DNA replication. Here the authors use Cryo-EM to describe the architecture of the Pol ε holoenzyme and to provide an atomic model for the leading strand replisome.
Externí odkaz:
https://doaj.org/article/bf5369f5dc0e4ac5973ac7d20dc7daaf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The DNA duplex is known to be split apart in a steric exclusion manner during replication, but the specific mechanism has remained unclear. Here the authors present a cryo-EM structure of a eukaryotic replicative CMG helicase on forked DNA, revealing
Externí odkaz:
https://doaj.org/article/28dfe286574d4c29930ab9b725ad275e
Autor:
Zuanning Yuan, Roxana Georgescu, Ruda de Luna Almeida Santos, Daniel Zhang, Lin Bai, Nina Y Yao, Gongpu Zhao, Michael E O'Donnell, Huilin Li
Publikováno v:
eLife, Vol 8 (2019)
The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have
Externí odkaz:
https://doaj.org/article/5a463b53e2944cfd8176059ff5dcaff9
Autor:
Ante Tocilj, Kin Fan On, Zuanning Yuan, Jingchuan Sun, Elad Elkayam, Huilin Li, Bruce Stillman, Leemor Joshua-Tor
Publikováno v:
eLife, Vol 6 (2017)
Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells. Here, we report the structure of the active form of human ORC determined by X-ray c
Externí odkaz:
https://doaj.org/article/2bc09d8d2ab84231998c10d4fd61521f
Autor:
Zuanning Yuan, Georgescu, Roxana, Yao, Nina Y., Yurieva, Olga, O'Donnell, Michael E. odonnel@rockefeller.edu, Huilin Li Huilin.Li@vai.org
Publikováno v:
Science. 8/2/2024, Vol. 385 Issue 6708, p513-513. 1p. 1 Diagram.
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Duplication of DNA genomes requires unwinding of the double-strand (ds) DNA so that each single strand (ss) can be copied by a DNA polymerase. The genomes of eukaryotic cells are unwound by two ring-shaped hexameric helicases that initially encircle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23278c85ae4bf145271d732006bad4f
https://doi.org/10.1073/pnas.2216240119
https://doi.org/10.1073/pnas.2216240119
Autor:
Amanda Kovach, Jessica Johl, Hemil Chauhan, Glenn T. Werneburg, Nadine S. Henderson, David G. Thanassi, Zuanning Yuan, Gongpu Zhao, Huilin Li, Minge Du
Publikováno v:
Journal of Urology. 206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14ccf21833f6db2436cb9d31c8780b5c
https://doi.org/10.1097/ju.0000000000002022.06
https://doi.org/10.1097/ju.0000000000002022.06
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/6/2022, Vol. 119 Issue 49, p1-10, 17p