Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Zu-Hang Sheng"'
Autor:
Ning Huang, Zu-Hang Sheng
Publikováno v:
Cell Regeneration, Vol 11, Iss 1, Pp 1-11 (2022)
Abstract Central nervous system (CNS) neurons typically fail to regenerate their axons after injury leading to neurological impairment. Axonal regeneration is a highly energy-demanding cellular program that requires local mitochondria to supply most
Externí odkaz:
https://doaj.org/article/3286bea7176c48a8be8a76cf593badb5
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Little is known about the pathways that maintain mitochondrial structure and function under neuronal stress conditions. Here, authors demonstrate that the Mul1-Mfn2 pathway plays a checkpoint role in maintaining mitochondrial integrity and energy mai
Externí odkaz:
https://doaj.org/article/6f1424b4200a43308728c4d36f509016
Autor:
Dinesh C. Joshi, Chuan-Li Zhang, Lavanya Babujee, Jason D. Vevea, Benjamin K. August, Zu-Hang Sheng, Edwin R. Chapman, Timothy M. Gomez, Shing Yan Chiu
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 685-696.e5 (2019)
Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive mul
Externí odkaz:
https://doaj.org/article/237993e2ba8e495b9b0742079b56acc3
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 51-64.e4 (2019)
Summary: Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology
Externí odkaz:
https://doaj.org/article/dc8c9c6aefb740a6840c6acb0c32f598
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 413-419 (2013)
One of the most notable characteristics of synaptic transmission is the wide variation in synaptic strength in response to identical stimulation. In hippocampal neurons, approximately one-third of axonal mitochondria are highly motile, and some dynam
Externí odkaz:
https://doaj.org/article/821d3c9d4c1146babca37fe992d17742
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 42-51 (2012)
Neurotrophin signaling is crucial for neuron growth. While the “signaling endosomes” hypothesis is one of the accepted models, the molecular machinery that drives retrograde axonal transport of TrkB signaling endosomes is largely unknown. In part
Externí odkaz:
https://doaj.org/article/99f70e51156c45b1acf0f2e1b2419414
Publikováno v:
eLife, Vol 3 (2014)
Parkinson's disease (PD) genes PINK1 and parkin act in a common pathway that regulates mitochondrial integrity and quality. Identifying new suppressors of the pathway is important for finding new therapeutic strategies. In this study, we show that MU
Externí odkaz:
https://doaj.org/article/91247786dda84072a177d285e71467fb
Autor:
Gui-Jing Xiong1, Zu-Hang Sheng1 shengz@ninds.nih.gov
Publikováno v:
Journal of Cell Biology. 6/3/2024, Vol. 223 Issue 6, p1-23. 23p.
Autor:
Xia Feng, Xiu-Tang Cheng, Pengli Zheng, Yan Li, Jill Hakim, Shirley Q Zhang, Stacie M Anderson, Kaari Linask, Ryan Prestil, Jizhong Zou, Zu-Hang Sheng, Craig Blackstone
Publikováno v:
Brain
Spinal bulbar muscular atrophy (SBMA), the first identified CAG-repeat expansion disorder, is an X-linked neuromuscular disorder involving CAG-repeat-expansion mutations in the androgen receptor (AR) gene. We utilized CRISPR-Cas9 gene editing to engi
Autor:
Zu-Hang Sheng, Sunan Li
Publikováno v:
Nature Reviews Neuroscience. 23:4-22
Synaptic activity imposes large energy demands that are met by local adenosine triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative phosphorylation. ATP drives action potentials, supports synapse assembly and remodelling, and f