Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Zu T. Shen"'
Autor:
Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated w
Externí odkaz:
https://doaj.org/article/ccc77c9aab1b4f15ad727746a758c049
Autor:
Charles A. Specht, Chrono K. Lee, Haibin Huang, Donald J. Tipper, Zu T. Shen, Jennifer K. Lodge, John Leszyk, Gary R. Ostroff, Stuart M. Levitz
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT A vaccine capable of protecting at-risk persons against infections due to Cryptococcus neoformans and Cryptococcus gattii could reduce the substantial global burden of human cryptococcosis. Vaccine development has been hampered though, by la
Externí odkaz:
https://doaj.org/article/6faaf383d1ef450988f01a6770c12ae6
Autor:
Adam O Whelan, Helen C Flick-Smith, Jane Homan, Zu T Shen, Zoe Carpenter, Payam Khoshkenar, Ambily Abraham, Nicola J Walker, Stuart M Levitz, Gary R Ostroff, Petra C F Oyston
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0200213 (2018)
Francisella tularensis is an intracellular pathogen causing the disease tularemia, and an organism of concern to biodefence. There is no licensed vaccine available. Subunit approaches have failed to induce protection, which requires both humoral and
Externí odkaz:
https://doaj.org/article/7ce61fccf8b049b09ebfd718d94ef34c
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143453 (2015)
Cardiovascular disease is the leading cause of death in Western cultures. The vast majority of cardiovascular events, including stroke and myocardial infarction, result from the rupture of vulnerable atherosclerotic plaques, which are characterized b
Externí odkaz:
https://doaj.org/article/3d2fd2766f144bf294e3a74c0fde0f69
Publikováno v:
Hepatology Communications
Alcoholic liver disease (ALD) is characterized by macrophage and neutrophil leukocyte recruitment and activation in the liver. Damage‐ and pathogen‐associated molecular patterns contribute to a self‐perpetuating proinflammatory state in ALD. Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3412fc555168b301846ece8b96c170cb
https://doi.org/10.1002/hep4.1269
https://doi.org/10.1002/hep4.1269
Autor:
Alexander B. Sigalov, Zu T. Shen
Publikováno v:
Journal of Cellular and Molecular Medicine
Triggering receptor expressed on myeloid cells 1 (TREM‐1) is critically involved in the pathogenesis of rheumatoid arthritis (RA). In contrast to cytokine blockers, therapeutic blockade of TREM‐1 can blunt excessive inflammation while preserving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0ccf79c9c155c622237a4bc015f54d
Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1864(9 Pt)
In pathological retinal neovascularization (RNV) disorders, the retina is infiltrated by activated leukocytes and macrophages. Triggering receptor expressed on myeloid cells 1 (TREM-1), an inflammation amplifier, activates monocytes and macrophages a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69cfc41da13b66c7ade72b321161e52
https://pubmed.ncbi.nlm.nih.gov/29730341
https://pubmed.ncbi.nlm.nih.gov/29730341
Autor:
Zu T. Shen, Alexander B. Sigalov
Publikováno v:
Mol Pharm
Pancreatic cancer (PC) is a highly lethal cancer with an urgent need to expand the limited treatment options for patients. Tumor-associated macrophages (TAMs) promote tumor aggressiveness and metastasis. High expression of triggering receptor express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc29f6e9bb7ad659ea695cac1bbfa09
https://europepmc.org/articles/PMC7243956/
https://europepmc.org/articles/PMC7243956/
Autor:
Denny Liggitt, Vijay K. Vanguri, Eric S. Huseby, Elizabeth Schutten, Priya G. Huseby, Zu T. Shen, Katsuhiro Sasaki, Angela M. Bean, Shivanee Shah, Björn Peters
Publikováno v:
The Journal of Immunology. 192:3029-3042
Multiple sclerosis (MS) is an inflammatory disease of the CNS that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons, and axons. Historically, MS has been thought to be a CD4 T cell–mediated autoimmune disease of CNS wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547bca056ec2df15081a725fc0e3cdc4
https://doi.org/10.4049/jimmunol.1302911
https://doi.org/10.4049/jimmunol.1302911
Publikováno v:
Cancer Research. 79:LB-193
Despite significant advances in cancer care, effective treatments are still lacking for non-small cell lung cancer (NSCLC), glioblastoma multiforme (GBM) and pancreatic cancer (PC) that are among the most lethal cancer types, necessitating the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::458b4e631d419642f421cc874d9f32e9
https://doi.org/10.1158/1538-7445.am2019-lb-193
https://doi.org/10.1158/1538-7445.am2019-lb-193