Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Zu D. Liu"'
Publikováno v:
Pharmacology & Toxicology. 86:228-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64454fb58e8dadf4720181a122e2de62
https://doi.org/10.1034/j.1600-0773.2000.pto860506.x
https://doi.org/10.1034/j.1600-0773.2000.pto860506.x
Publikováno v:
Journal of Mass Spectrometry. 40:1203-1214
Herein, we report the structural analysis of a novel family of iron-chelating dendrimers and their synthetic intermediates utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and electrospray ionizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7968b63747f6b62c973f8bed6f9314
https://doi.org/10.1002/jms.899
https://doi.org/10.1002/jms.899
Publikováno v:
Tetrahedron Letters. 46:1333-1336
Two novel hexadentate 3-hydroxypyridin-4-one ligands have been designed and synthesised. The physico-chemical properties of one of the hexadentate ligands have been determined and the results indicate that the hexadentate ligand possesses high affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b12980e9d95a78be92bd1a4c00e2eb
https://doi.org/10.1016/j.tetlet.2004.12.115
https://doi.org/10.1016/j.tetlet.2004.12.115
Publikováno v:
Tetrahedron Letters. 45:9393-9396
Two novel iron(III)-selective hexadentate chelator-terminated dendrimers have been synthesized in high yields. MALDI-TOF mass spectra demonstrate that both dendritic chelators bind iron(III) efficiently. Preliminary studies show that these molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a774dccfd4da31b9d0918ed1de9e5f8a
https://doi.org/10.1016/j.tetlet.2004.10.110
https://doi.org/10.1016/j.tetlet.2004.10.110
Publikováno v:
Journal of Pharmacy and Pharmacology. 56:529-536
Bidentate chelators such as hydroxypyridinones and hydroxypyranones are highly iron selective. The synthesis of two novel fluorescent probes N-[2-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)ethyl]-2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamide (CP600) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83576b38074915f8d095ea07b93e75b
https://doi.org/10.1211/0022357023196
https://doi.org/10.1211/0022357023196
Autor:
Zu D. Liu, Robert C. Hider
Publikováno v:
Coordination Chemistry Reviews. 232:151-171
Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B, the most widely used iron chelator in haematology over the past 30 years, has a major disadvantage of being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36bc288111f7310d858c150f607a4fb0
https://doi.org/10.1016/s0010-8545(02)00050-4
https://doi.org/10.1016/s0010-8545(02)00050-4
Publikováno v:
Best Practice & Research Clinical Haematology. 15:369-384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04c80e86a652e512ba8ad552320c27f
https://doi.org/10.1053/beha.2002.0209
https://doi.org/10.1053/beha.2002.0209
Publikováno v:
Journal of Medicinal Chemistry. 45:631-639
A range of novel 3-hydroxypyridin-4-ones with different R(2) substitutents has been synthesized for the investigation of the structure-activity relationship between the chemical nature of the ligand and the inhibitory activity of the iron-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d629d1dec7e06b70184c362e7bb81db
https://doi.org/10.1021/jm010817i
https://doi.org/10.1021/jm010817i
Publikováno v:
Tetrahedron. 57:3479-3486
Novel methods for the synthesis of high pFe 3+ iron chelators, 2-(1′-hydroxyalkyl)- and 2-amido-3-hydroxypyridin-4-ones, have been developed. The products are obtained, via N -oxide intermediates, from either maltol or ethyl maltol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6ff47997adc2fd2370921666ea571ec
https://doi.org/10.1016/s0040-4020(01)00222-8
https://doi.org/10.1016/s0040-4020(01)00222-8
Publikováno v:
Pharmacology and Toxicology. 86:228-233
1-(3'-Hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) has been extensively investigated as an orally effective iron chelator. In order to improve the pharmacokinetic and metabolic properties of CP41, eleven aromatic esters have been synthesised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7c9d0ca8f74aac6ad1645c7aa32ec
https://doi.org/10.1034/j.1600-0773.2000.d01-40.x
https://doi.org/10.1034/j.1600-0773.2000.d01-40.x