Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Zu‐Lin Chen"'
Autor:
Hanna E. Berk-Rauch, Arnab Choudhury, Allison T. Richards, Pradeep K. Singh, Zu-Lin Chen, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Introduction: Alzheimer’s Disease (AD) patients exhibit signs of motor dysfunction, including gait, locomotion, and balance deficits. Changes in motor function often precede other symptoms of AD as well as correlate with increased severity and mort
Externí odkaz:
https://doaj.org/article/e8dd3bdad140483d8f9a6408a48204d9
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 7, Pp n/a-n/a (2022)
Abstract Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface. Overactivation of this system contributes
Externí odkaz:
https://doaj.org/article/85105e2bcb564e23accdfe63f3d783d3
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-8 (2019)
Abstract Background Systemic inflammation has been implicated in the progression of many neurodegenerative diseases and may be an important driver of the disease. Dementia and cognitive decline progress more rapidly following acute systemic infection
Externí odkaz:
https://doaj.org/article/9c79d806c2df4456952cda461e27cc59
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 4, Pp n/a-n/a (2021)
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting millions of people worldwide. Extracellular beta‐amyloid (Aβ) plaques and neurofibrillary tau tangles are classical hallmarks of AD pathology and thus are th
Externí odkaz:
https://doaj.org/article/cb99a66b04c643fd990d98ea37074c76
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104833- (2020)
Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits, brain atrophy, vascular dysfunction, and chronic inflammation. Along with cerebral inflammation, peripheral inflammation is also evident in many AD patients. B
Externí odkaz:
https://doaj.org/article/74ac5c3d23394c9489d8ff2730ee0501
Autor:
Georgette L. Suidan, Pradeep K. Singh, Sunita Patel-Hett, Zu-Lin Chen, Dmitri Volfson, Hitomi Yamamoto-Imoto, Erin H. Norris, Robert D. Bell, Sidney Strickland
Publikováno v:
Blood Advances, Vol 2, Iss 9, Pp 954-963 (2018)
Abstract: Alzheimer disease (AD) is a neurodegenerative disorder characterized by extracellular β-amyloid (Aβ) deposition. Although peripheral inflammation and cerebrovascular pathology are reported in AD, there is a lack of plasma biomarkers in th
Externí odkaz:
https://doaj.org/article/0e4f33cbf5d94a24b3f2a05f21603c2b
Autor:
Hitomi Yamamoto‐Imoto, Daria Zamolodchikov, Zu‐Lin Chen, S. Lloyd Bourne, Syeda Rizvi, Pradeep Singh, Erin H. Norris, Frances Weis‐Garcia, Sidney Strickland
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 480-489 (2018)
Abstract Introduction Accumulation of β‐amyloid is a pathological hallmark of Alzheimer's disease (AD). β‐Amyloid activates the plasma contact system leading to kallikrein‐mediated cleavage of intact high‐molecular‐weight kininogen (HKi)
Externí odkaz:
https://doaj.org/article/736a60c21d2c42abb28c56a2c65bc95c
Autor:
Singh, Pradeep Kumar, Simões-Pires, Elisa Nicoloso, Zu-Lin Chen, Torrente, Daniel, Calvano, Marissa, Sharma, Anurag, Strickland, Sidney, Norris, Erin H.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/23/2024, Vol. 121 Issue 17, p1-3, 8p
Autor:
Zu-Lin Chen, Pradeep K. Singh, Katharina Horn, Marissa R. Calvano, Shigeru Kaneki, Keith R. McCrae, Sidney Strickland, Erin H. Norris
Publikováno v:
Blood Advances. 7:1156-1167
A dysregulated plasma contact system is involved in various pathological conditions, such as hereditary angioedema, Alzheimer disease, and sepsis. We previously showed that the 3E8 anti–high molecular weight kininogen (anti-HK) antibody blocks HK c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec367307bc731f50c40b58f351407f54
https://doi.org/10.1182/bloodadvances.2021006485
https://doi.org/10.1182/bloodadvances.2021006485
Publikováno v:
Blood Advances. 6:3090-3101
Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia. Vascular abnormalities and neuroinflammation play roles in AD pathogenesis. Plasma contact activation, which leads to fibrin clot formation and bradykinin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd194e3d0c02fb6ccdf9e4e88f10764
https://doi.org/10.1182/bloodadvances.2021006612
https://doi.org/10.1182/bloodadvances.2021006612