Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain

Autor: Xiao-Jun Xu, Tao Li, Jian-Dong Jiang, Zsuzsanna Wiesenfeld-Hallin, Tianle Gao, Tiansheng Shi

Publikováno v: European Journal of Pharmacology. 854:101-108

Management of chronic pain is restricted by the lack of effective tools. This study evaluated the efficacies of sinomenine combined gabapentin or ligustrazine hydrochloride in treating peripheral and central chronic neuropathic pain. The study was co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e136d731d798950a05c6aebbd3d7da3c
https://doi.org/10.1016/j.ejphar.2019.03.061

Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis

Autor: Jie Su, Zsuzsanna Wiesenfeld-Hallin, Jon Lampa, Camilla I. Svensson, Tianle Gao, Katalin Sandor, Johanna Estelius, Xiao-Jun Xu, Nilesh M. Agalave, Tomas Hökfelt, Teresa Fernandez-Zafra, Franziska Denk, Zoe Hore, Alexandra Jurczak

Publikováno v: Fernandez-Zafra, T, Gao, T, Jurczak, A, Sandor, K, Hore, Z, Agalave, N M, Su, J, Estelius, J, Lampa, J, Hokfelt, T, Wiesenfeld-Hallin, Z, Xu, X, Denk, F & Svensson, C I 2019, ' Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis ', Pain, vol. 160, no. 1, pp. 224-236 . https://doi.org/10.1097/j.pain.0000000000001394
PAIN

Recent studies have suggested a sexually dimorphic role of spinal glial cells in the maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used the collagen antibody-induced arthritis (CAIA) mouse model to examine diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74055b42331a1818883b666bc29cd0d2
https://kclpure.kcl.ac.uk/en/publications/86a700d4-eb22-4cd9-9eda-84f1568547b2

Delayed Imatinib Treatment for Acute Spinal Cord Injury: Functional Recovery and Serum Biomarkers

Autor: Zsuzsanna Wiesenfeld-Hallin, Ulf Eriksson, Jacob Kjell, Camilla I. Svensson, Lars Olson, Anna Josephson, Mathew Abrams, Katrin Wellfelt, Anja Finn, Jing-Xia Hao

Publikováno v: Journal of Neurotrauma

With no currently available drug treatment for spinal cord injury, there is a need for additional therapeutic candidates. We took the approach of repositioning existing pharmacological agents to serve as acute treatments for spinal cord injury and pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc4822b4fb07c65ef17da44da8b5213
http://europepmc.org/articles/PMC4752188

Quantitative test of responses to thermal stimulation in spinally injured rats using a Peltier thermode: A new approach to study cold allodynia

Autor: Zsuzsanna Wiesenfeld-Hallin, Tianle Gao, Xiao-Jun Xu, Jing-Xia Hao

Publikováno v: Journal of Neuroscience Methods. 212:317-321

In this work, we described a method of testing of responses of spinally injured rats to thermal stimulation (heating and cooling) to the flank area using a Peltier thermode. With a baseline holding temperature at 32°C and the temperature change rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7827e6788374e22cdcd6f28681084f
https://doi.org/10.1016/j.jneumeth.2012.11.008

Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice

Autor: Tianle Gao, Xiao Zhang, Israel Vlodavsky, Jin-Ping Li, Xiao-Jun Xu, Jing-Xia Hao, Lili Li, Bo Wang, Zsuzsanna Wiesenfeld-Hallin

Publikováno v: Neuroscience Letters. 511:4-7

Heparanase controls the structure and functions of extracellular matrix (ECM) by degrading heparan sulfate proteoglycans. Heparanase is involved in inflammatory process through modulating the functions of inflammatory cytokines. The present study aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba98ddd37cec59c5ff6a0d40bf6dbab
https://doi.org/10.1016/j.neulet.2011.12.038