55P0110, a Novel Synthetic Compound Developed from a Plant Derived Backbone Structure, Shows Promising Anti-Hyperglycaemic Activity in Mice.

Autor: Barbara Brunmair, Zsuzsanna Lehner, Karin Stadlbauer, Immanuel Adorjan, Klaus Frobel, Thomas Scherer, Anton Luger, Leonhardt Bauer, Clemens Fürnsinn

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126847 (2015)

Starting off with a structure derived from the natural compound multiflorine, a derivatisation program aimed at the discovery and initial characterisation of novel compounds with antidiabetic potential. Design and discovery of the structures was guid

Externí odkaz: https://doaj.org/article/cfb83a19a408451387640ce906788fe1

Preclinical characterization of 55P0251, a novel compound that amplifies glucose-stimulated insulin secretion and counteracts hyperglycaemia in rodents

Autor: Leonhardt Bauer, Zsuzsanna Lehner, Anton Luger, Clemens Fürnsinn, Karin Stadlbauer, B. Brunmair, Thomas Scherer, Immanuel Adorjan

Publikováno v: Diabetes, Obesity and Metabolism. 19:1088-1096

Aims 55P0251 is a novel compound with blood glucose lowering activity in mice, which has been developed from a molecular backbone structure found in herbal remedies. We here report its basic pharmacological attributes and initial progress in unmaskin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a6747d72993e7af6e1f84981b003c6d
https://doi.org/10.1111/dom.12914

Usability and Fun of the INTERACCT Client

Autor: Helmut Hlavacs, Fares Kayali, Jens Kuczwara, Rebecca Wölfle, Anita Lawitschka, Andrea Reithofer, Daniel Martinek, Konrad Peters, Ruth Mateus-Berr, Barbara Brunmair, Zsuzsanna Lehner

Publikováno v: Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering ISBN: 9783319496542
eHealth 360°

We present the INTERACCT system, a smartphone app and a Web page for fostering communication between young patients in aftercare after a stem cell transplantation. In this phase of rehabilitation, daily communication between the patients and their cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f196f084d79200419de6bd9af2a8291
https://doi.org/10.1007/978-3-319-49655-9_21

Lipophilicity as a determinant of thiazolidinedione action in vitro: findings from BLX-1002, a novel compound without affinity to PPARs

Autor: Karin Stadlbauer, B. Brunmair, Clemens Fürnsinn, Zsuzsanna Lehner, Katrin Staniek, Charles W. Bolten, Debendranath Dey, Anton Luger

Publikováno v: American Journal of Physiology-Cell Physiology. 300:C1386-C1392

The pharmacology of thiazolidinediones (TZDs) seems to be driven not only by activation of peroxisome proliferator-activated receptor-γ (PPARγ), but also by PPARγ-independent effects on mitochondrial function and cellular fuel handling. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e9656bdeea37e22d139f3dd3b1958a
https://doi.org/10.1152/ajpcell.00401.2010

Participatory Game Design for the INTERACCT Serious Game for Health

Autor: Manuel Sprung, Anita Lawitschka, Fares Kayali, Daniel Martinek, Rebecca Wölfle, Konrad Peters, Ruth Mateus-Berr, Zsuzsanna Lehner, Marisa Silbernagl, Andrea Reithofer, Jens Kuczwara, Helmut Hlavacs

Publikováno v: Serious Games ISBN: 9783319191256
JCSG

In this paper we present results from our user-centered and participative design approach using methods from design thinking and explorative design with school children aged 8 - 14 in context with a game created for children after cancer treatment. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7778eb1fe7fee535b8fa57b640009b37
https://doi.org/10.1007/978-3-319-19126-3_2