Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Zsuzsanna Helyes"'
Autor:
Ádám István Horváth, Kata Bölcskei, Nikolett Szentes, Éva Borbély, Valéria Tékus, Bálint Botz, Kitti Rusznák, Anett Futácsi, Boldizsár Czéh, Péter Mátyus, Zsuzsanna Helyes
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionMonoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxa
Externí odkaz:
https://doaj.org/article/7cfe2dd453ac46c1bfdceb5f12491f4b
Autor:
Violetta Mohos, Máté Harmat, Jozsef Kun, Tímea Aczél, Balázs Zoltán Zsidó, Tamás Kitka, Sándor Farkas, Erika Pintér, Zsuzsanna Helyes
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Chronic orofacial pain disorders are common debilitating conditions, affecting the trigeminal system. Its underlying pathophysiological mechanisms are still unclear and the therapy is often unsatisfactory, therefore, preclinical models are crucial to
Externí odkaz:
https://doaj.org/article/0da16444d64d4f5b857d671439b6ffac
Autor:
Rebecca Mountford, Brittany L. Adler, David Andersson, Rachael Bashford-Rogers, Richard Berwick, Stuart Bevan, Xavier Caro, Tae Hwan Chung, J. David Clark, John M. Dawes, Xinzhong Dong, Zsuzsanna Helyes, Wade Kingery, Joost J. van Middendorp, Harvey Neiland, Margot Maurer, Carmen Scheibenbogen, Katharina Schmack, Thomas Schreiner, Camilla I. Svensson, Valéria Tékus, Andreas Goebel
Publikováno v:
PAIN Reports, Vol 9, Iss 4, p e1167 (2024)
Abstract. A 2-day closed workshop was held in Liverpool, United Kingdom, to discuss the results of research concerning symptom-based disorders (SBDs) caused by autoantibodies, share technical knowledge, and consider future plans. Twenty-two speakers
Externí odkaz:
https://doaj.org/article/d2890ffbc47c48bda34575e7e82fdf06
Autor:
Petra Pallagi, Emese Tóth, Marietta Görög, Viktória Venglovecz, Tamara Madácsy, Árpád Varga, Tünde Molnár, Noémi Papp, Viktória Szabó, Enikő Kúthy‐Sutus, Réka Molnár, Attila Ördög, Katalin Borka, Andrea Schnúr, Albert Kéri, Gyula Kajner, Kata Csekő, Emese Ritter, Dezső Csupor, Zsuzsanna Helyes, Gábor Galbács, Andrea Szentesi, László Czakó, Zoltán Rakonczay, Tamás Takács, József Maléth, Péter Hegyi
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background and aims Smoking is recognised as an independent risk factor in the development of chronic pancreatitis (CP). Cystic fibrosis transmembrane conductance regulator (CFTR) function and ductal fluid and bicarbonate secretion are also
Externí odkaz:
https://doaj.org/article/bb0b5498491740efb425d176ec8a9b2e
Autor:
Éva Borbély, Angéla Kecskés, József Kun, Eszter Kepe, Barbara Fülöp, Katalin Kovács-Rozmer, Bálint Scheich, Éva Renner, Miklós Palkovits, Zsuzsanna Helyes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The Tac4 gene-derived hemokinin-1 (HK-1) binds to the NK1 receptor, similarly to Substance P, and plays a role in acute stress reactions and pain transmission in mice. Here we investigated Tac4 mRNA expression in stress and pain-related regi
Externí odkaz:
https://doaj.org/article/e52d5aee3a544516987c691bffd30f12
Autor:
Andrea Kinga Nehr-Majoros, János Erostyák, Éva Fenyvesi, Edina Szabó-Meleg, Levente Szőcs, György Sétáló, Zsuzsanna Helyes, Éva Szőke
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are nonselective cation channels expressed in primary sensory neurons and several other non-neuronal structures such as immune cells, keratinocytes, and vascular smooth muscle cel
Externí odkaz:
https://doaj.org/article/3d5d77025afb4f0a92c2eef3f0b4a52b
Autor:
Sylvester R. Groen, Daniel Keszthelyi, Arpad Szallasi, Jara A. van Veghel, Annick M. E. Alleleyn, Kata Csekő, Zsuzsanna Helyes, Iryna Samarska, Heike I. Grabsch, Ad A. M. Masclee, Zsa Zsa R. M. Weerts
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8294 (2024)
The potential role of the transient receptor potential Vanilloid 1 (TRPV1) non-selective cation channel in gastric carcinogenesis remains unclear. The main objective of this study was to evaluate TRPV1 expression in gastric cancer (GC) and precursor
Externí odkaz:
https://doaj.org/article/614d235874ef409e9d18c8c9b325f50e
Autor:
Bernadett Zsoldos, Nóra Nagy, Viktória Donkó-Tóth, Péter Keglevich, Márton Weber, Miklós Dékány, Andrea Nehr-Majoros, Éva Szőke, Zsuzsanna Helyes, László Hazai
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7929 (2024)
A series of novel vindoline–piperazine conjugates were synthesized by coupling 6 N-substituted piperazine pharmacophores at positions 10 and 17 of Vinca alkaloid monomer vindoline through different types of linkers. The in vitro antiproliferative a
Externí odkaz:
https://doaj.org/article/1970f873c05d44cb8da4c8e4980250dd
Autor:
Ádám Horváth, Anita Steib, Andrea Nehr-Majoros, Boglárka Kántás, Ágnes Király, Márk Racskó, Balázs István Tóth, Eszter Szánti-Pintér, Eva Kudová, Rita Skoda-Földes, Zsuzsanna Helyes, Éva Szőke
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4637 (2024)
The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletio
Externí odkaz:
https://doaj.org/article/c2bceb37f6ae48bb886761140e606e57
Autor:
Lina Hudhud, Katalin Rozmer, Angéla Kecskés, Krisztina Pohóczky, Noémi Bencze, Krisztina Buzás, Éva Szőke, Zsuzsanna Helyes
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3760 (2024)
Osteosarcoma is a highly malignant, painful cancer with poor treatment opportunities and a bad prognosis. Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are non-selective cation channels that have been of great inter
Externí odkaz:
https://doaj.org/article/c178bc80bf6d4b2f99b5422518aa5eb8