Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

Autor: Gordon, K. B, Blauvelt, A., Papp, K. A., Langley, R. G., Luger, T., Ohtsuki, M., Reich, K., Amato, D., Ball, S. G., Braun, D. K., Cameron, G. S., Erickson, J., Konrad, R. J., Muram, T. M., Nickoloff, B. J., Osuntokun, O. O., Secrest, R. J., Zhao, F., Mallbris, L., Leonardi, C. L., Uncover, 1 Study Group: Holly Hake Harris, Matheson, Robert T., Michael, Bukhalo, John H., Tu, Crowley, Jeffrey J., Grande, Kimberly K., Adnan, Nasir, Boni Elizabeth Elewski, James Alan Solomon, Liebhild, Stratmann, Claudia, Buettner, Thomas Peter Dirschka, Margrit Ruth Simon, Jens, Ulrich, Christine, Grigat, Mathias, Augustin, Andrei, Khariouzov, Gerhard, Sattler, Hans Michael Ockenfels, Fredrick Richard Behringer, Hector, Wiltz, Francisco, Flores, Kuettel, Kevin D., Ira Hughes Thorla, Jeffrey Keith Moore, Waterman, Gary L., George Joji Murakawa, Scott Alfred Fretzin, Frankel, Ellen H., Sunil Sharan Dhawan, Lucyna, Leszniewska, Maria, Poznanska, Anna Sobieszek Kundro, Chodorowska, Grazyna M., Katarzyna Turek Urasinska, Romuald, Maleszka, Andrzej, Kaszuba, Lidia, Rajzer, Elizbieta Barbara Szymanska, Lidia, Rudnicka, Neil James Korman, Jamie Debra Weisman, Truett, Artis P., Jeffry, Jacqmein, Steven Robert Cohen, Heller, Gary L., Jenkin, Peter J., Abe, Marcadis, George Sorin Tiplica, Anca Aghinitei Zbranca Toporas, Simona Laura Ianosi, Ion, Florea, Claus, Zachariae, Lars, Iversen, Annalisa, Patrizi, Romanelli, Marco, Christopher, Griffiths, John Berth Jones, John, Foerster, Savin, Ronald C., Nelson, Christopher G., Lyn Carol Chamberlain Guenther, Albrecht, Lorne E., Hong, Chih ho H., Arnon, Katz, Mani, Raman, Adam, David N., Aamir, Butt, Stephen Peter Shumack, Kurt Aaron Josef Gebauer, Lynda Jane Spelman, Shireen Kaur Sidhu, Michael George Freeman, Peter Anthony Foley, Lajos, Kemeny, Eva, Remenyik, Zsuzsanna, Karolyi, Marc, Bourcier, Wayne Douglas Carey, Victoria, Taraska, Derek, Haaland, Aditya Kumar Gupta, Catherine, Maari, Darryl Paul Toth, Michael, Sebastian, Sandra, Philipp, Roland, Kaufmann, Diamant, Thaci, Thomas Andreas Werfel, Leila, Parise, Ingo, Haase, Petra Staubach Renz, Shinichi, Imafuku, Juichiro, Nakayama, Tadashi, Terui, Hideki, Nakajima, Shigetoshi, Sano, Uncover, 2 Study Group, Uncover, 3 Study Group

Publikováno v: New England Journal of Medicine. 375:345-356

BACKGROUND Two phase 3 trials (UNCOVER-2 and UNCOVER-3) showed that at 12 weeks of treatment, ixekizumab, a monoclonal antibody against interleukin-17A, was superior to placebo and etanercept in the treatment of moderate-to-severe psoriasis. We repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb30bf3a03c1849628a03f8c5fc3e43
https://doi.org/10.1056/nejmoa1512711

Cardiometabolic biomarkers in chronic plaque psoriasis before and after etanercept treatment*.

Autor: Puig, Lluís¹ (AUTHOR) lpuig@santpau.cat, Strohal, Robert² (AUTHOR), Fuiman, Joanne³ (AUTHOR), Pedersen, Ronald³ (AUTHOR), Szumski, Annette³ (AUTHOR), Koenig, Andrew S.³ (AUTHOR), Robertson, Deborah³ (AUTHOR), Drexel, Heinz^4,5,6 (AUTHOR)

Publikováno v: Journal of Dermatological Treatment. Dec2014, Vol. 25 Issue 6, p470-481. 12p.

The efficacy and safety of etanercept when used with as-needed adjunctive topical therapy in a randomised, double-blind study in subjects with moderate-to-severe psoriasis (the PRISTINE trial).

Autor: Strohal, Robert¹ (AUTHOR) robert.strohal@lkhf.at, Puig, Luis² (AUTHOR), Chouela, Edgardo³ (AUTHOR), Tsai, Tsen-Fang⁴ (AUTHOR), Melin, Jeffrey⁵ (AUTHOR), Freundlich, Bruce⁶ (AUTHOR), Molta, Charles T.⁵ (AUTHOR), Fuiman, Joanne⁵ (AUTHOR), Pedersen, Ronald⁵ (AUTHOR), Robertson, Deborah⁵ (AUTHOR)

Publikováno v: Journal of Dermatological Treatment. Jun2013, Vol. 24 Issue 3, p169-178. 10p.

Dynamic changes in the trends in incidence of type 1 diabetes in children in Hungary (1978-98).

Autor: Gyurus, Eva, Green, Anders, Patterson, Chris C., Soltesz, Gyula

Publikováno v: Pediatric Diabetes; Dec2002, Vol. 3 Issue 4, p194, 6p

1624-1631

Autor: Martin Opitz, Veronika Marschall, Robert Seidel

Der Poet, Literaturreformer, Diplomat und Kulturpolitiker Martin Opitz (1597-1639) ist bekannt als „Vater der deutschen Dichtung“. Als wichtiger Vertreter des europäischen Späthumanismus verfasste er jedoch einen großen Teil seiner Werke auf L