Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zsombor Kőszegi"'
Autor:
Zsolt Kristóf Bali, Nóra Bruszt, Zsombor Kőszegi, Lili Veronika Nagy, Tamás Atlasz, Péter Kovács, Dezső Csupor, Boglárka Csupor-Löffler, István Hernádi
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2067 (2022)
Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain
Externí odkaz:
https://doaj.org/article/ba1d438732894b2d97f590ea0ccde687
Autor:
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Visualizing endogenous GPCRs is challenging. Here the authors generate mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, design fluorescent dyes for specific labelling in complex tissue, and reve
Externí odkaz:
https://doaj.org/article/a1c114f010cf4dc7bafcaf994b474beb
Autor:
Marie-Lise Jobin, Sana Siddig, Zsombor Koszegi, Yann Lanoiselée, Vladimir Khayenko, Titiwat Sungkaworn, Christian Werner, Kerstin Seier, Christin Misigaiski, Giovanna Mantovani, Markus Sauer, Hans M. Maric, Davide Calebiro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.
Externí odkaz:
https://doaj.org/article/151c7286e0224e3e936b73cfadb10add
Autor:
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O’Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, ar
Externí odkaz:
https://doaj.org/article/31913551d70443ecbc6be0521f89476a
Autor:
Zsombor Koszegi, Rachel Y. Cheong
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Estrogens can alter the biology of various tissues and organs, including the brain, and thus play an essential role in modulating homeostasis. Despite its traditional role in reproduction, it is now accepted that estrogen and its analogues can exert
Externí odkaz:
https://doaj.org/article/ea92ede2a90944ac8e25b689ba5fd224
Publikováno v:
Endocrinology. 152(9)
17 -Estradiol (E2) treatment exerts rapid, nonclassical actions via intracellular signal transduction system in basal forebrain cholinergic (BFC) neurons in vivo. Here we examined the effect of E2 treatment on lesioned BFC neurons in ovariectomized m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b665dae2e3ca5cf233df6c7fe05e01f7
https://pubmed.ncbi.nlm.nih.gov/21791565
https://pubmed.ncbi.nlm.nih.gov/21791565
Publikováno v:
Psychoneuroendocrinology. 34
Extensive studies during the past two decades provide compelling evidence that the gonadal steroid, estrogen, has the potential to affect the viability of basal forebrain cholinergic neurons. These observations reflect a unique ameliorative feature o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883b88e240bea2b25c301ce2b4f999da
https://pubmed.ncbi.nlm.nih.gov/19560872
https://pubmed.ncbi.nlm.nih.gov/19560872
Autor:
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 r
Externí odkaz:
https://doaj.org/article/1bec881e08194ff3b4ad84658e067529
Publikováno v:
Entropy, Vol 23, Iss 8, p 1044 (2021)
In this article, we introduce a new method to detect transient trapping events within a single particle trajectory, thus allowing the explicit accounting of changes in the particle’s dynamics over time. Our method is based on new measures of a smoo
Externí odkaz:
https://doaj.org/article/8b4c9e392b7b4054839df5acb6aa5a84
Autor:
Teresa Buenaventura, Stavroula Bitsi, William E Laughlin, Thomas Burgoyne, Zekun Lyu, Affiong I Oqua, Hannah Norman, Emma R McGlone, Andrey S Klymchenko, Ivan R Corrêa, Abigail Walker, Asuka Inoue, Aylin Hanyaloglu, Jak Grimes, Zsombor Koszegi, Davide Calebiro, Guy A Rutter, Stephen R Bloom, Ben Jones, Alejandra Tomas
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000097 (2019)
The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of th
Externí odkaz:
https://doaj.org/article/8615184b004840e48897e4b6bd2088e9