The Effects of Hypoxia on the Immune-Modulatory Properties of Bone Marrow-Derived Mesenchymal Stromal Cells

Autor: Zsolt Fábián

Publikováno v: Stem Cells International, Vol 2019 (2019)

The therapeutic repertoire for life-threatening inflammatory conditions like sepsis, graft-versus-host reactions, or colitis is very limited in current clinical practice and, together with chronic ones, like the osteoarthritis, presents growing econo

Externí odkaz: https://doaj.org/article/881dfaa907a2425fa439184507ee230e

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes

Autor: Daniel Crean, Antonella Naldini, Carsten C. Scholz, Bettina Schaible, Zsolt Fábián, Helen M. Roche, Susan F. Fitzpatrick, Hugh E. Giffney, Doug N. Halligan, Bianca Crifo, Alfonso Blanco, Anna M. Kirwan, Miguel Cavadas, Mattia Criscuoli, Eoin P. Cummins, Eric Brown, Cormac T. Taylor

Hypoxia is a common and prominent feature of the microenvironment at sites of bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d39b33c612dbb0718e36ea61dfc5a5
https://www.zora.uzh.ch/id/eprint/169137/

Stem Cell-Derived Extracellular Vesicles in the Treatment of Cardiovascular Diseases

Autor: Jennifer McDonald, Sidhesh Mohak, Zsolt Fabian

Publikováno v: Pharmaceutics, Vol 16, Iss 3, p 381 (2024)

Cardiovascular disease constitutes a noteworthy public health challenge characterized by a pronounced incidence, frequency, and mortality rate, particularly impacting specific demographic groups, and imposing a substantial burden on the healthcare in

Externí odkaz: https://doaj.org/article/cf09f94551ff42d8a8eb11814169a3ab

Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1α activity

Autor: Cormac T. Taylor, Sivaramakrishnan Ramadurai, Heinz-Peter Nasheuer, Walter Kolch, Zsolt Fábián, Frank Barry, Georgina Shaw

Publikováno v: Stem Cell Research. 12:646-658

Human bone marrow stromal cells (hBMSCs, also known as bone marrow-derived mesenchymal stem cells) are promising tools for the cellular therapy of human pathologies related to various forms of hypoxia. Although the current concepts of their clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf385222950f60f1b0fa838a0a60d1b
https://doi.org/10.1016/j.scr.2014.02.007

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner

Autor: Susan F. Fitzpatrick, Mario C. Manresa, Zsolt Fábián, Alex von Kriegsheim, Cormac T. Taylor, Peter Carmeliet, Yvonne M. O'Meara, Glen Doherty, Zongwei Li, Peter Fraisl, Eoin P. Cummins, Bettina Schaible, Murtaza M. Tambuwala, Myriam Baes, Craig Slattery, Ulrike Bruning, Javier Rodriguez, Xingnan Zheng, Colin R. Lenihan, Desmond G. Higgins, Thomas Schwarzl

Publikováno v: Fitzpatrick, S F, Fábián, Z, Schaible, B, Lenihan, C R, Schwarzl, T, Rodriguez, J, Zheng, X, Li, Z, Tambuwala, M M, Higgins, D G, O'Meara, Y, Slattery, C, Manresa, M C, Fraisl, P, Bruning, U, Baes, M, Carmeliet, P, Doherty, G, von Kriegsheim, A, Cummins, E P & Taylor, C T 2016, ' Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner ', Biochemical and Biophysical Research Communications, vol. 474, no. 3, pp. 579-86 . https://doi.org/10.1016/j.bbrc.2016.04.085

Hepatocyte death is an important contributing factor in a number of diseases of the liver. PHD1 confers hypoxic sensitivity upon transcription factors including the hypoxia inducible factor (HIF) and nuclear factor-kappaB (NF-κB). Reduced PHD1 activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c355b84a1b42497ed3ab3cc534d55cfd
https://pubmed.ncbi.nlm.nih.gov/27130823