Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

Autor: Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Laura Bergamaschi, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Paul A. Lyons, Erik J. M. Toonen, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through diff

Externí odkaz: https://doaj.org/article/766e52fb320d462daa94e2918960d612

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Autor: György Sinkovits, Blanka Mező, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Zoltán Prohászka

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

ObjectivesUncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers

Externí odkaz: https://doaj.org/article/67ea6f4569ef49ea92cd7c5838956c30

Prothrombotic alterations of von Willebrand factor level and ADAMTS13 activity in hospitalized COVID-19 patients

Autor: Zsolt Förhécz, Tamás Masszi, István Vályi-Nagy, Ilona Bobek, Blanka Mező, P. Reményi, Erika Kajdácsi, B Szathmáry, M. Reti, Petra Kiszel, L Hurler, Dorottya Csuka, György Sinkovits, Zita Z. Prohászka, János Gál, János Szlávik, László Cervenak, Botond Lakatos, László Gopcsa, Zsolt Iványi, Veronika Müller

Publikováno v: 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::377fce8f2f7e44afe77b31d205b4ede4
https://doi.org/10.1055/s-0041-1728127

Association of ficolin-3 with severity and outcome of chronic heart failure.

Autor: Zoltán Prohászka, Lea Munthe-Fog, Thor Ueland, Timea Gombos, Arne Yndestad, Zsolt Förhécz, Mikkel-Ole Skjoedt, Zoltan Pozsonyi, Alice Gustavsen, Lívia Jánoskuti, István Karádi, Lars Gullestad, Christen P Dahl, Erik T Askevold, George Füst, Pål Aukrust, Tom E Mollnes, Peter Garred

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60976 (2013)

BACKGROUND: Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the le

Externí odkaz: https://doaj.org/article/d9aa4c2e045c444997483c0f62bd0674

Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure

Autor: Tímea Gombos, Zsolt Förhécz, István Karádi, Lívia Jánoskuti, Zoltán Prohászka, Zoltán Pozsonyi, Zsigmond Jenei

Predicting the survival of a patient with heart failure (HF) is a complex problem in clinical practice. Our previous study reported that extracellular HSP70 (HSPA1A) correlates with markers of heart function and disease severity in HF, but the predic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a58cfc376dd4ba4ba180eeae0846b5
https://europepmc.org/articles/PMC3789876/