Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zsofia Bittner"'
Autor:
Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NE
Externí odkaz:
https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c4
Autor:
Franziska Herster, Zsofia Bittner, Marius Cosmin Codrea, Nathan K. Archer, Martin Heister, Markus W. Löffler, Simon Heumos, Joanna Wegner, Ramona Businger, Michael Schindler, David Stegner, Knut Schäkel, Stephan Grabbe, Kamran Ghoreschi, Lloyd S. Miller, Alexander N. R. Weber
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes, but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils
Externí odkaz:
https://doaj.org/article/8dd172ca07bd406789dc6f14dcbecf2e
Autor:
Alexander N. R. Weber, Zsofia Bittner, Xiao Liu, Truong-Minh Dang, Markus Philipp Radsak, Cornelia Brunner
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Bruton’s tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity. Growing evidence also suggests multiple roles for BTK in mononuclear cells of the i
Externí odkaz:
https://doaj.org/article/e2e8feebeec24ae9ad022f83c4475b69
Autor:
Alena Reguzova, Melanie Sigle, Felix Pagallies, Ferdinand Salomon, Hanns-Joachim Rziha, Zsofia Bittner-Schrader, Babs Verstrepen, Kinga Böszörményi, Ernst Verschoor, Knut Elbers, Meral Esen, Alessandro Manenti, Martina Monti, Madiha Derouazi, Hans-Georg Rammensee, Markus Löffler, Ralf Amann
The next generation of COVID-19 vaccines needs to broaden the antigenic repertoire to improve breadth of immune response and efficacy against emerging variants of concern. This study describes a new parapoxvirus-based vector (ORFV) as a platform to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577827168c406a3bcdb56c57a30fd68e
https://doi.org/10.21203/rs.3.rs-2832501/v1
https://doi.org/10.21203/rs.3.rs-2832501/v1
Autor:
Zsofia Bittner, Ana Tapia-Abellán, Alexander N.R. Weber, Tengchuan Jin, Tzu-Hsuan Chang, Xiao Liu, Sangeetha Shankar
Publikováno v:
Journal of Cell Science. 133
The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a fascinating cellular machinery endowed with the capacity for rapid proteolytic processing of the pro-inflammatory cytokine IL-1β and the cell death effector gasdermin D (G
Autor:
Sabine Dickhöfer, Oliver Hantschel, Hubert Kalbacher, Anita Delor, Franziska Herster, Jasmin Kümmerle-Deschner, Bodo Grimbacher, Carsten L. Greve, Xiao Liu, Ana Marcu, Samuel Wagner, Hao Wu, Liudmila Andreeva, Ana Tapia-Abellán, Yamel Cardona Gloria, Alexander N.R. Weber, Marta Lovotti, Eicke Latz, Michael Scharl, Markus W. Löffler, Maria Mateo Tortola, Olaf-Oliver Wolz, Nadine A. Schilling, Peter Düwell, Matthew Mangan, Sangeetha Shankar, Tzu-Hsuan Chang, Zsofia Bittner, Stefan Stevanovic, Karlotta Bosch, Francesca Bork, Marianne R. Spalinger
Publikováno v:
Journal of experimental medicine 218(11), e20201656 (2021). doi:10.1084/jem.20201656
Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that a well-establ
Autor:
Dominik Hartl, Thomas Knorpp, Hubert Kalbacher, Knut Schäkel, Nicole Schneiderhan-Marra, Holger Heine, Lloyd S. Miller, Sabine Dickhöfer, Zsofia Bittner, Tatjana Eigenbrod, Kamran Ghoreschi, Tim Vierbuchen, Markus W. Löffler, Nathan K. Archer, Franziska Herster, Martin Heister, Alexander N.R. Weber, Lukas Freund, David Eisel
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. How
Autor:
Jasmin Kümmerle-Deschner, Peter Düwell, Matthew Mangan, Ana Marcu, Olaf-Oliver Wolz, Ana Tapia-Abellán, Franziska Herster, Sangeetha Shankar, Hao Wu, Sabine Dickhöfer, Marta Lovotti, Anita Delor, Samuel Wagner, Liudmila Andreeva, Eicke Latz, Hubert Kalbacher, Markus W. Löffler, Bodo Grimbacher, Zsofia Bittner, Alexander N.R. Weber, Xiao Liu, Karlotta Bosch, Nadine A. Schilling, Stefan Stevanovic
Activity of the NLRP3 inflammasome, a critical mediator of inflammation (1), is controlled by accessory proteins (2, 3), post-translational modifications (4, 5), cellular localization (6, 7) and oligomerization (8). How these factors relate, is uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750f84b4b4fe9a704faa78e0a1d51e60
https://doi.org/10.1101/864702
https://doi.org/10.1101/864702
Autor:
Markus W. Löffler, Stephan Grabbe, Martin Heister, Kamran Ghoreschi, Joanna Wegner, David Stegner, Alexander N.R. Weber, Simon Heumos, Franziska Herster, Ramona Businger, Nathan K. Archer, Zsofia Bittner, Lloyd Miller, Marius Cosmin Cordrea, Michael Schindler, Knut Schäkel
Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadb3bc15f244d5dc3432c5a024ccc4d
https://doi.org/10.1101/526236
https://doi.org/10.1101/526236
Autor:
Kirsten J. Koymans, Alexander N.R. Weber, Cécile Gouttefangeas, Carly A. Dillen, Sabine Dickhöfer, Christoph Taumer, Zsofia Bittner, Daniel J. Haischer, Boris Macek, Thorsten Nürnberger, Andrea A. Gust, Milena Krach, Martin Frank, Anurag Singh, Nadine A. Schilling, Didier Le Roy, Felix Frauhammer, Tharmila Sanmuganantham, Olaf Oliver Wolz, Salomé LeibundGut-Landmann, Truong Minh Dang, Lloyd S. Miller, Katharina Fuchs, Thierry Roger, Yamel Cardona Gloria, Charles S. Dela Cruz, Maria A. Schlöffel, Franziska Herster, Lokesh Sharma, Dominik Hartl
Publikováno v:
EMBO reports. 19
Chitin is the second most abundant polysaccharide in nature and linked to fungal infection and asthma. However, bona fide immune receptors directly binding chitin and signaling immune activation and inflammation have not been clearly identified becau