Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Zsófia Hajna"'
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1182 (2022)
There is an unmet need for novel therapeutic tools relieving chronic pain. Hydrogen sulfide (H2S) is highly involved in pain processes; however, the development of ideal matrices for sulfide donor compounds remains a great pharmaceutical challenge. W
Externí odkaz:
https://doaj.org/article/297e54a607eb4782a62b01424575b9cf
Autor:
Zsófia Hajna, Kata Csekő, Ágnes Kemény, László Kereskai, Tamás Kiss, Anikó Perkecz, István Szitter, Béla Kocsis, Erika Pintér, Zsuzsanna Helyes
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4109 (2020)
The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and
Externí odkaz:
https://doaj.org/article/e8c2320279ee4ea5ae3c77e559c7fb56
Autor:
Eva Borbély, Zsófia Hajna, Katalin Sándor, László Kereskai, István Tóth, Erika Pintér, Péter Nagy, János Szolcsányi, John Quinn, Andreas Zimmer, James Stewart, Christopher Paige, Alexandra Berger, Zsuzsanna Helyes
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61684 (2013)
Substance P, encoded by the Tac1 gene, is involved in neurogenic inflammation and hyperalgesia via neurokinin 1 (NK1) receptor activation. Its non-neuronal counterpart, hemokinin-1, which is derived from the Tac4 gene, is also a potent NK1 agonist. A
Externí odkaz:
https://doaj.org/article/6e29c74aeecd4bb39a15d7b3cfc09ae1
Autor:
Zsuzsanna Helyes, Valéria Tékus, Alexandra Berger, Éva Borbély, Tamás Ollmann, Julie Keeble, Christopher J. Paige, Zsófia Hajna, Viktória Kormos, János Szolcsányi, Erika Pintér, László Lénárd, Bálint Scheich, John P. Quinn, Balázs Gaszner, Kristóf László, Zoltán Karádi, Liza Nabi
Publikováno v:
BRAIN BEHAVIOR AND IMMUNITY
Borbély, É, Hajna, Z, Nabi, L, Scheich, B, Tékus, V, László, K, Ollmann, T, Kormos, V, Gaszner, B, Karádi, Z, Lénárd, L, Paige, C J, Quinn, J P, Szolcsányi, J, Pintér, E, Keeble, J, Berger, A & Helyes, Z 2017, ' Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice ', Brain, Behavior, and Immunity, vol. 59, pp. 219–232 . https://doi.org/10.1016/j.bbi.2016.09.004
Borbély, É, Hajna, Z, Nabi, L, Scheich, B, Tékus, V, László, K, Ollmann, T, Kormos, V, Gaszner, B, Karádi, Z, Lénárd, L, Paige, C J, Quinn, J P, Szolcsányi, J, Pintér, E, Keeble, J, Berger, A & Helyes, Z 2017, ' Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice ', Brain, Behavior, and Immunity, vol. 59, pp. 219–232 . https://doi.org/10.1016/j.bbi.2016.09.004
The tachykinin NK1 receptor was suggested to be involved in psychiatric disorders, but its antagonists have failed to be effective as antidepressants in clinical trials. Hemokinin-1 (HK-1), the newest tachykinin, is present in several brain regions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cefff0c7a6730cb4fe0dd516d3579a4
https://doi.org/10.1016/j.bbi.2016.09.004
https://doi.org/10.1016/j.bbi.2016.09.004
Autor:
Erika Pintér, Katalin Sándor, László Kereskai, Kata Csekő, Zsófia Hajna, Krisztián Elekes, John P. Quinn, Ágnes Kemény, Zsuzsanna Helyes, István Szitter
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39db1640bb47185425f27e39c53e25f7
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb69
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb69
Autor:
Aisah A. Aubdool, Maja Payrits, István Bátai, Zsófia Hajna, Lívia Nagy, Susan D. Brain, Gábor Pozsgai, Erika Pintér, D. Filotás, Zsuzsanna Helyes, Éva Sághy, Éva Szőke
Publikováno v:
Journal of Molecular Neuroscience. 60:157-170
It is supposed that TRPA1 receptor can be activated by hydrogen sulphide (H2S). Here, we have investigated the role of TRPA1 receptor in H2S-induced [Ca(2+)]i increase in trigeminal ganglia (TRG) neurons, and the involvement of capsaicin-sensitive se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb44b942bd803c4d20e3f7c558ad4e6
https://doi.org/10.1007/s12031-016-0802-z
https://doi.org/10.1007/s12031-016-0802-z
Autor:
Zsófia Hajna, Kata Bölcskei, Melinda Boros, Erika Pintér, Zsuzsanna Helyes, Ádám Horváth, Éva Borbély, Valéria Tékus, János Szolcsányi, Gábor Pethő
Publikováno v:
Life Sciences. 154:66-74
Aims To investigate the roles of TRPV1 and TRPA1 channels in baseline and allyl isothiocyanate (AITC)-evoked nociceptive responses by comparing wild-type and gene-deficient mice. Main methods In contrast to conventional methods of thermonociception m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f847a7438b2c330b597d9d96d93d69
https://doi.org/10.1016/j.lfs.2016.04.030
https://doi.org/10.1016/j.lfs.2016.04.030
Autor:
Bálint Scheich, Éva Borbély, Zsuzsanna Helyes, Balázs Gaszner, Zsófia Hajna, Ágnes Kemény, Ágnes Hunyady, Timea Gubanyi
Publikováno v:
Brain research bulletin. 147
The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates the tachykinin NK1 receptor, but with binding site and signaling pathways different from Substance P (SP). NK1 receptor is involved in nociception, but our earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ce51d30001eeeb4a59b48c89f2e3fc
https://pubmed.ncbi.nlm.nih.gov/30664920
https://pubmed.ncbi.nlm.nih.gov/30664920
Autor:
Alexandra Berger, Éva Borbély, Ágnes Kemény, Christopher J. Paige, Bálint Botz, János Szolcsányi, Erika Pintér, Zsuzsanna Helyes, Zsófia Hajna, László Kereskai
Publikováno v:
Peptides. 64:1-7
Objective Hemokinin-1, the newest tachykinin encoded by the preprotachykinin C (Tac4) gene, is predominatly produced by immune cells. Similarly to substance P, it has the greatest affinity to the tachykinin NK1 receptor, but has different binding sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70357c3c407a7b9d0c9e01858926ac1
https://doi.org/10.1016/j.peptides.2014.12.002
https://doi.org/10.1016/j.peptides.2014.12.002
Publikováno v:
British Journal of Clinical Pharmacology. 77:5-20
Cross-talk between the nervous, endocrine and immune systems exists via regulator molecules, such as neuropeptides, hormones and cytokines. A number of neuropeptides have been implicated in the genesis of inflammation, such as tachykinins and calcito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54fab34c453ec86b7ed70814912a7690
https://doi.org/10.1111/bcp.12097
https://doi.org/10.1111/bcp.12097