Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Autor: Antonis Asiminas, Sam A. Booker, Owen R. Dando, Zrinko Kozic, Daisy Arkell, Felicity H. Inkpen, Anna Sumera, Irem Akyel, Peter C. Kind, Emma R. Wood

Publikováno v: Molecular Autism, Vol 13, Iss 1, Pp 1-29 (2022)

Abstract Background Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting t

Externí odkaz: https://doaj.org/article/e0dabc1eced84dd8ab6b7b80f7f03aae

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Autor: Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozic, Owen R. Dando, Adam D. Jackson, Paul S. Baxter, Lori L. Isom, Diane L. Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind

Publikováno v: Cell Reports, Vol 32, Iss 6, Pp 107988- (2020)

Summary: Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segmen

Externí odkaz: https://doaj.org/article/43e9885c0bb64e499d98b5c2d2ae7c83

PAX6 LIMITS THE COMPETENCE OF DEVELOPING CEREBRAL CORTICAL CELLS

Autor: Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E. P. Henderson, Neil C. Henderson, Wai Kit Chan, Michael I. Daw, John O. Mason, David J. Price

The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcb52e91c214a31c289a122f34df6701
https://doi.org/10.1101/2022.02.03.478927

Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons

Autor: Price Dj, Thomas Pratt, Tian Tian, Zrinko Kozic, Idoia Quintana-Urzainqui

Pax6 is a well-known regulator of early neuroepithelial progenitor development. We discovered that it can also influence the later morphological and functional development of neurons in the prethalamus, which are unusual in retaining Pax6 expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624f85bb01cae1c51d75b205c9c1d047
https://doi.org/10.1101/2021.03.22.436455

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Autor: Giles E. Hardingham, Sam A. Booker, Peter J. Brophy, Lori L. Isom, Peter C. Kind, Natasha J. Anstey, Owen Dando, Paul Baxter, Zrinko Kozic, Diane L. Sherman, David J. A. Wyllie, Adam D. Jackson, Laura Simões de Oliveira

Publikováno v: Cell Reports
Cell Reports, Vol 32, Iss 6, Pp 107988-(2020)
Booker, S, Simões De Oliveira, L, Anstey, N, Kozic, Z, Dando, O, Jackson, A, Baxter, P, Isom, L L, Sherman, D, Hardingham, G, Brophy, P, Wyllie, D & Kind, P 2020, ' Input-output relationship of CA1 pyramidal neurons reveals intact homeostatic mechanisms in a mouse model of Fragile X Syndrome ', Cell Reports . https://doi.org/10.1016/j.celrep.2020.107988

Summary Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9797275eb9aaa429ebde97331a1a50
http://europepmc.org/articles/PMC7435362