Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Zoya N. Demidenko"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26126 (2011)
Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incom
Externí odkaz:
https://doaj.org/article/c61d0441bed246a68b901ab5934810d2
Publikováno v:
Cell Cycle
Markers of cellular senescence depend in part on the MTOR (mechanistic target of rapamycin) pathway. MTOR participates in geroconversion, a conversion from reversible cell cycle arrest to irreversible senescence. Recently we demonstrated that hyper-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc287af19c42b31d9677d342c4786b2b
https://doi.org/10.4161/cc.26248
https://doi.org/10.4161/cc.26248
Autor:
Zoya N. Demidenko, James A. McCubrey
Publikováno v:
Aging (Albany NY)
The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff3254bbd11b71e896bb30f309539fb
https://doi.org/10.18632/aging.100529
https://doi.org/10.18632/aging.100529
Publikováno v:
Cell Cycle
When the cell cycle is arrested, even though growth-promoting pathways such as mTOR are still active, then cells senesce. For example, induction of either p21 or p16 arrests the cell cycle without inhibiting mTOR, which, in turn, converts p21/p16-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221237a5fc1c1f67009c18db695e724a
https://doi.org/10.4161/cc.22937
https://doi.org/10.4161/cc.22937
Autor:
Zoya N. Demidenko, Mikhail A. Nikiforov, Olga V. Leontieva, A. E. Berman, James A. McCubrey, Venkatesh Natarajan
Publikováno v:
Oncotarget
It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm is being replaced by the "
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f023991e44428e1f2642e63d79917b56
http://europepmc.org/articles/PMC3681491
http://europepmc.org/articles/PMC3681491
Autor:
Stephen L. Abrams, Melchiorre Cervello, Piotr Laidler, Ferdinando Nicoletti, Matilde Y. Follo, Agnieszka Gizak, Giuseppe Montalto, James A. McCubrey, Lucio Cocco, Kvin Lertpiriyapong, Joanna Dulińska-Litewka, Massimo Libra, Linda S. Steelman, Zoya N. Demidenko, Danijela Maksimović-Ivanić, Alberto M. Martelli, Agustino Tafuri, Saverio Candido, Luca M. Neri, Sandra Marmiroli, Dariusz Rakus, Michelle Milella, Joerg Basecke, Aurora Scalisi, Concettina Fenga, Sanja Mijatović, Timothy L. Fitzgerald, Lyudmyla Drobot
Publikováno v:
Scopus-Elsevier
Current Pharmaceutical Design
Current Pharmaceutical Design
The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers including breast, bladder, brain, colorectal, esophageal, gastric, head and neck, hepatocellular, lung, neuroblastoma, ovarian, pancreatic, prostate, renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee19fe79bdabcbbeb752ef81f105d76
http://hdl.handle.net/11573/909740
http://hdl.handle.net/11573/909740
Autor:
James A. McCubrey, Zoya N. Demidenko
Publikováno v:
Aging (Albany NY)
In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new original therapeutic strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2fc8d2fa30581a7e506dcc94cc025d
https://doi.org/10.18632/aging.100421
https://doi.org/10.18632/aging.100421
Publikováno v:
Cell Cycle. 10:1557-1562
Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further transactivates PHDs. It is thought that the purpose of this feedback loop is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af322428c1d9afc8d9868a5dfd946d1
https://doi.org/10.4161/cc.10.10.15789
https://doi.org/10.4161/cc.10.10.15789
Autor:
Lioubov G. Korotchkina, Elena I. Bukreeva, Andrei V. Gudkov, Zoya N. Demidenko, Olga V. Leontieva, Mikhail V. Blagosklonny
Publikováno v:
Aging (Albany NY)
Transient induction of p53 can cause reversible quiescence and irreversible senescence. Using nutlin-3a (a small molecule that activates p53 without causing DNA damage), we have previously identified cell lines in which nutlin-3a caused quiescence. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19fc300cbcc625978e40d58b4ae9ad5
https://doi.org/10.18632/aging.100160
https://doi.org/10.18632/aging.100160
Publikováno v:
Proceedings of the National Academy of Sciences. 107:9660-9664
The tumor suppressor p53 is a canonical inducer of cellular senescence (irreversible loss of proliferative potential and senescent morphology). p53 can also cause reversible arrest without senescent morphology, which has usually been interpreted as f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c78487bc7dd6c60ec5a278b0989d635
https://doi.org/10.1073/pnas.1002298107
https://doi.org/10.1073/pnas.1002298107