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Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence.

Autor: Hou J; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Chen KX; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., He C; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Li XX; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China., Huang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Jiang YZ; School of Biomedical Sciences, Institute for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.; Center for Neuromusculoskeletal Restorative Medicine, Hong Kong Special Administrative Region of China, Hong Kong, China., Jiao YR; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Xiao QN; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., He WZ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Liu L; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Zou NY; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Huang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Wei J; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, China.; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China., Xiao Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Yang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China., Luo XH; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Zeng C; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China. zengchao@csu.edu.cn.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China. zengchao@csu.edu.cn.; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, China. zengchao@csu.edu.cn.; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China. zengchao@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. zengchao@csu.edu.cn., Lei GH; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China. lei_guanghua@csu.edu.cn.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China. lei_guanghua@csu.edu.cn.; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, China. lei_guanghua@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. lei_guanghua@csu.edu.cn., Li CJ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China. lichangjun@csu.edu.cn.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China. lichangjun@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. lichangjun@csu.edu.cn.; Laboratory Animal Center, Xiangya Hospital, Central South University, Changsha, China. lichangjun@csu.edu.cn.

Publikováno v: Nature aging [Nat Aging] 2024 Sep 12. Date of Electronic Publication: 2024 Sep 12.

Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing.

Autor: Zou NY; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Liu R; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Huang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Jiao YR; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Wei J; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China.; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, 410008, China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China., Jiang Y; School of Biomedical Sciences, Institute for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., He WZ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Huang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Xu YL; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Liu L; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Sun YC; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Yang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Guo Q; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Huang Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Su T; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Xiao Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China., Wang WS; Department of Orthopaedics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China., Zeng C; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China.; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, 410008, China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Lei GH; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China.; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, 410008, China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Luo XH; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China. xianghangluo@hotmail.com.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China. xianghangluo@hotmail.com.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. xianghangluo@hotmail.com., Li CJ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China. lichangjun@csu.edu.cn.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China. lichangjun@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. lichangjun@csu.edu.cn.

Publikováno v: Bone research [Bone Res] 2024 Jan 25; Vol. 12 (1), pp. 6. Date of Electronic Publication: 2024 Jan 25.

Knockdown of FAM83D Enhances Radiosensitivity in Coordination with Irradiation by Inhibiting EMT via the Akt/GSK-3β/Snail Signaling Pathway in Human Esophageal Cancer Cells.

Autor: Yang XX; Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People's Republic of China., Ma M; Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People's Republic of China., Sang MX; Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People's Republic of China., Zhang XY; Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People's Republic of China., Zou NY; Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People's Republic of China., Zhu SC; Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, People's Republic of China.

Publikováno v: OncoTargets and therapy [Onco Targets Ther] 2020 May 26; Vol. 13, pp. 4665-4678. Date of Electronic Publication: 2020 May 26 (Print Publication: 2020).