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AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells.

Autor: Ye, Lupeng, Lam, Stanley Z., Yang, Luojia, Suzuki, Kazushi, Zou, Yongji, Lin, Qianqian, Zhang, Yueqi, Clark, Paul, Peng, Lei, Chen, Sidi

Publikováno v: Nature Biomedical Engineering; Feb2024, Vol. 8 Issue 2, p132-148, 17p

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages.

Autor: Ren P; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Hu Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Peng L; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Yang L; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Suzuki K; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Fang Z; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Bai M; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Zhou L; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.; Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA., Feng Y; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.; Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA., Zou Y; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Chen S; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; System Biology Institute, Yale University, West Haven, CT, USA.; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.; Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA.; Immunobiology Program, Yale University, New Haven, CT, USA.; Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT, USA.; Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Center for Biomedical Data Science, Yale University School of Medicine, New Haven, CT, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 15. Date of Electronic Publication: 2023 Mar 15.