Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Zoran Radic"'
1
Akademický článek
Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.
Autor: Liyi Geng, Yang Gao, Xiabin Chen, Shurong Hou, Chang-Guo Zhan, Zoran Radic, Robin J Parks, Stephen J Russell, Linh Pham, Stephen Brimijoin
Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67446 (2013)
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and
Externí odkaz: https://doaj.org/article/e8400e27058b4e2ca6d43525baaffb47
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2
Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice
Autor: Stephen Chang, John Tat, Shyamsundar Pal China, Hema Kalyanaraman, Shunhui Zhuang, Adriano Chan, Cassandra Lai, Zoran Radic, Engy A Abdel-Rahman, Darren E Casteel, Renate B Pilz, Sameh S Ali, Gerry R Boss
Publikováno v: PNAS nexus, vol 1, iss 4
Increased oxidative stress underlies a variety of diseases, including diabetes. Here, we show that the cobalamin/vitamin B12 analog cobinamide is a strong and multifaceted antioxidant, neutralizing superoxide, hydrogen peroxide, and peroxynitrite, wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dce683c3d9d7b25074f119984a7ab2
https://escholarship.org/uc/item/7zg553bs
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7
Akademický článek
The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism
Autor: Yves Bourne, Gerlind Sulzenbacher, Laurent Chabaud, Rómulo Aráoz, Zoran Radić, Sandrine Conrod, Palmer Taylor, Catherine Guillou, Jordi Molgó, Pascale Marchot
Publikováno v: Marine Drugs, Vol 22, Iss 4, p 149 (2024)
Macrocyclic imine phycotoxins are an emerging class of chemical compounds associated with harmful algal blooms and shellfish toxicity. Earlier binding and electrophysiology experiments on nAChR subtypes and their soluble AChBP surrogates evidenced co
Externí odkaz: https://doaj.org/article/e2a8c4f697904501875d503c589a25e4
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8
Akademický článek
Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure
Autor: Oksana Gerlits, Matthew P. Blakeley, David A. Keen, Zoran Radić, Andrey Kovalevsky
Publikováno v: Current Research in Structural Biology, Vol 3, Iss , Pp 206-215 (2021)
Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. Human AChE (hAChE) is a target of nerve agent and pesticide organophosphorus compounds that covalently a
Externí odkaz: https://doaj.org/article/0fdbb2fad6eb4eb6a5ed3166563a6633
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