Zobrazeno 1 - 10
of 349
pro vyhledávání: '"Zoran Culig"'
Autor:
Juan Guzman, Katrin Weigelt, Angela Neumann, Philipp Tripal, Benjamin Schmid, Zoltán Winter, Ralph Palmisano, Zoran Culig, Marcus V. Cronauer, Paul Muschler, Bernd Wullich, Helge Taubert, Sven Wach
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background The androgen/androgen receptor (AR)-signaling axis plays a central role in prostate cancer (PCa). Upon androgen-binding the AR dimerizes with another AR, and translocates into the nucleus where the AR-dimer activates/inactivates a
Externí odkaz:
https://doaj.org/article/540315149f484863b24ccb2561a69445
Autor:
Margareta Pernar Kovač, Vanja Tadić, Juran Kralj, Marija Milković Periša, Slavko Orešković, Ivan Babić, Vladimir Banović, Wei Zhang, Zoran Culig, Anamaria Brozovic
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115349- (2023)
Background: DNA methylation, histone modifications, and miRNAs affect ovarian cancer (OC) progression and therapy response. Purpose: Identification of epigenetically downregulated miRNAs in drug-resistant OC cell lines with a possible role in drug re
Externí odkaz:
https://doaj.org/article/3a5adc27b66f4d39b8655e906c2fbaec
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/91e4cbb22d284d98a4e0cedad096ca1c
Autor:
Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer, Sarka Pospisilova, Helmut Dolznig, Wolfgang Wadsak, Zoran Culig, Suzanne D. Turner, Gerda Egger, Sabine Lagger, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. However, the biological consequences of
Externí odkaz:
https://doaj.org/article/5aaf49f7c7c74c4eb49241877d305439
Autor:
Maria Frantzi, Zoran Culig, Isabel Heidegger, Marika Mokou, Agnieszka Latosinska, Marie C. Roesch, Axel S. Merseburger, Manousos Makridakis, Antonia Vlahou, Ana Blanca-Pedregosa, Julia Carrasco-Valiente, Harald Mischak, Enrique Gomez-Gomez
Publikováno v:
Cancers, Vol 15, Iss 4, p 1166 (2023)
(1) Background: Prostate cancer (PCa) is the most frequently diagnosed cancer in men. Wide application of prostate specific antigen test has historically led to over-treatment, starting from excessive biopsies. Risk calculators based on molecular and
Externí odkaz:
https://doaj.org/article/75d352ee6ec144a384735a9995b500c8
Autor:
Olesya Vakhrusheva, Holger H. H. Erb, Vitus Bräunig, Sascha D. Markowitsch, Patricia Schupp, Patrick C. Baer, Kimberly Sue Slade, Anita Thomas, Igor Tsaur, Martin Puhr, Zoran Culig, Jindrich Cinatl, Martin Michaelis, Thomas Efferth, Axel Haferkamp, Eva Juengel
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to exhibit tumor suppressive properties. Therefore, the therapeutic potential of artesunate (ART)
Externí odkaz:
https://doaj.org/article/e8bf3189c0f242e381ae779a1a745f9c
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Andrea Katharina Lindner, Tobias Furlan, Jacob J. Orme, Gennadi Tulchiner, Nina Staudacher, David D’Andrea, Zoran Culig, Renate Pichler
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 8, p 2208 (2022)
Platinum-based chemotherapy is the standard of care with concern to first-line systemic therapy for metastatic disease in urothelial cancer (UC). Resistance to chemotherapy despite an initial response is linked with the ability to remove platinum-bas
Externí odkaz:
https://doaj.org/article/c454740aa4e9418bb19b177b51ab4f5b
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Externí odkaz:
https://doaj.org/article/150e35241d6a4464be7e559790c1cedd
Autor:
Holger H H Erb, Julia Bodenbender, Florian Handle, Tamara Diehl, Lukas Donix, Igor Tsaur, Martin Gleave, Axel Haferkamp, Johannes Huber, Susanne Fuessel, Eva Juengel, Zoran Culig, Christian Thomas
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237248 (2020)
Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of trans
Externí odkaz:
https://doaj.org/article/4e67266c59d74563ae1dc628b1acd121