Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion

Autor: Marion T. Turnbull, Zoran Boskovic, Elizabeth J. Coulson

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Degeneration of basal forebrain cholinergic neurons (BFCNs) precedes hippocampal degeneration and pathological amyloid-beta (Aβ) accumulation, and underpins the development of cognitive dysfunction in sporadic Alzheimer’s disease (AD). We hypothes

Externí odkaz: https://doaj.org/article/704920360754404cb02cc93e4f74a758

Gas7 Is a Novel Dendritic Spine Initiation Factor

Autor: Pushpa Khanal, Zoran Boskovic, Lauri Lahti, Aruna Ghimire, Rimante Minkeviciene, Patricio Opazo, Pirta Hotulainen

Funding Information: This work was funded by Academy of Finland Grant SA 307735 (to P.H.); the Doctoral Programme Brain & Mind, University of Helsinki (P.K.); the United Kingdom Dementia Research Institute partner funders (Medical Research Council, A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8081d8bf4452ff202c79d07347ad7
https://aaltodoc.aalto.fi/handle/123456789/120822

Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors

Autor: Yunpeng Wang, Zoran Boskovic, Michael R. Milne, Tessa Onraet, Elizabeth J. Coulson, Sonja Meier, Angelo Tedoldi

Publikováno v: Neuronal Signaling

Cholinergic basal forebrain (cBF) neurons are defined by their expression of the p75 neurotrophin receptor (p75NTR) and tropomyosin-related kinase (Trk) neurotrophin receptors in addition to cholinergic markers. It is known that the neurotrophins, pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cc56fb32126626c91c1d43b65de93d
https://doi.org/10.1042/ns20180066

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Autor: Xiang Li, Michael S. Kobor, Yi E. Sun, Zoran Boskovic, Vikram S. Ratnu, Wei Wei, Carlos M. Coelho, Kevin J. Dudley, Danay Baker-Andresen, Timothy W. Bredy, Quan Lin

Publikováno v: Nature Neuroscience. 14:1115-1117

MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85ba938c03babd7ec357927587c17cb
https://doi.org/10.1038/nn.2891

Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

Autor: Henri Autio, Peder Madsen, Simon Glerup, Elizabeth J. Coulson, Dusan Matusica, Eero Castrén, Anders Nykjaer, Alex M. Sykes, Sune Skeldal, Zoran Boskovic, Nickless Palstra

Publikováno v: Skeldal, S, Sykes, A M, Glerup, S, Matusica, D, Palstra, N, Autio, H, Boskovic, Z, Madsen, P, Castrén, E, Nykjaer, A & Coulson, E J 2012, ' Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis ', Journal of Biological Chemistry, vol. 287, no. 52, pp. 43798-809 . https://doi.org/10.1074/jbc.M112.374710

Neurotrophins comprise a group of neuronal growth factors that are essential for the development and maintenance of the nervous system. However, the immature pro-neurotrophins promote apoptosis by engaging in a complex with sortilin and the p75 neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05a65529a8a86c954c7c8f93b46169
https://pure.au.dk/portal/da/publications/mapping-of-the-interaction-site-between-sortilin-and-the-p75-neurotrophin-receptor-reveals-a-regulatory-role-for-the-sortilin-intracellular-domain-in-p75-neurotrophin-receptor-shedding-and-apoptosis(e5b557c1-ee9b-4673-a152-80a30d548ed5).html