Regulatory Crosstalk between Physiological Low O2 Concentration and Notch Pathway in Early Erythropoiesis

Autor: Véronique Labat, Eva Nguyen van Thanh dit Bayard, Alice Refeyton, Mathilde Huart, Maryse Avalon, Christelle Debeissat, Laura Rodriguez, Philippe Brunet de la Grange, Zoran Ivanovic, Marija Vlaski-Lafarge

Publikováno v: Biomolecules, Vol 12, Iss 4, p 540 (2022)

Physiological low oxygen (O2) concentration (2 concentration, via the stabilization of hypoxia-induced transcription factors (HIFs), intervenes with Notch signaling in the control of cell fate. In addition, Notch activation is implicated in the regul

Externí odkaz: https://doaj.org/article/c9ec872aa2fc44619424e9fe40f0b2f9

Normal Hematopoetic Stem and Progenitor Cells Can Exhibit Metabolic Flexibility Similar to Cancer Cells

Autor: Marija Vlaski-Lafarge, Veronique Labat, Alexandra Brandy, Alice Refeyton, Pascale Duchez, Laura Rodriguez, Nyere Gibson, Philippe Brunet de la Grange, Zoran Ivanovic

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

It is known that cancer stem cells (CSCs) with the largest proliferative capacity survive the anoxic and/or ischemic conditions present inside tumorous tissue. In this study we test whether normal stem cells can survive under the same conditions due

Externí odkaz: https://doaj.org/article/f651b76c7a114986917cb75371690dd8

α-Tocopherol Attenuates Oxidative Phosphorylation of CD34+ Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance

Autor: Laura Rodriguez, Pascale Duchez, Nicolas Touya, Christelle Debeissat, Amélie V. Guitart, Jean-Max Pasquet, Marija Vlaski-Lafarge, Philippe Brunet de la Grange, Zoran Ivanovic

Publikováno v: Biomolecules, Vol 11, Iss 4, p 558 (2021)

Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic hypothesis of stem cells, we studied the impact of αTOA on the metabolic energetic profile and

Externí odkaz: https://doaj.org/article/07711e9f716f41cb8dec20444779abdf

Correction: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

Autor: Pierre Milpied, Arnaud Villacreces, Christelle Piperoglou, Eric Vivier, Frédéric Vély, Laurine Gil, Adeline Crinier, Pierre-Yves Dumas, Zoran Ivanovic, Emilie Narni-Mancinelli, Bertrand Escalière

Publikováno v: Cellular and molecular immunology
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2021, ⟨10.1038/s41423-021-00771-z⟩
Cellular and molecular immunology, 2020, ⟨10.1038/s41423-020-00574-8⟩
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2020, ⟨10.1038/s41423-020-00574-8⟩
Cellular and molecular immunology, 2021, ⟨10.1038/s41423-021-00771-z⟩
Cell Mol Immunol
Cellular and Molecular Immunology
Cellular & Molecular Immunology

SummaryNatural killer (NK) cells are innate cytotoxic lymphoid cells (ILCs) involved in the killing of infected and tumor cells. Among human and mouse NK cells from the spleen and blood, we previously identified by single-cell RNA sequencing (scRNAse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db9a272e1824050ed6f9da921d0a723
https://doi.org/10.1038/s41423-021-00771-z

Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells

Autor: Marine Dupont, Mathilde Huart, Claire Lauvinerie, Audrey Bidet, Amélie Valérie Guitart, Arnaud Villacreces, Isabelle Vigon, Vanessa Desplat, Ali El Habhab, Arnaud Pigneux, Zoran Ivanovic, Philippe Brunet De la Grange, Pierre-Yves Dumas, Jean-Max Pasquet

Publikováno v: Cancers
Cancers, Vol 14, Iss 453, p 453 (2022)
Cancers; Volume 14; Issue 2; Pages: 453
Cancers, 2022, 14 (2), pp.453. ⟨10.3390/cancers14020453⟩

Simple Summary One of the most frequent molecular anomalies in acute myeloid leukemia (AML) is the mutation of the fms-like receptor tyrosine kinase 3 through internal tandem duplications, giving rise to a constitutive proliferative signaling. Even t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9d3730986691e7846176276cdc4e5d
https://pubmed.ncbi.nlm.nih.gov/35053612