Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles

Autor: Tareq B. Malas, Wouter N. Leonhard, Hester Bange, Zoraide Granchi, Kristina M. Hettne, Gerard J.P. Van Westen, Leo S. Price, Peter A.C. 't Hoen, Dorien J.M. Peters

Publikováno v: EBioMedicine, Vol 51, Iss , Pp - (2020)

Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common causes of end-stage renal failure, caused by mutations in PKD1 or PKD2 genes. Tolvaptan, the only drug approved for ADPKD treatment, results in serious side-ef

Externí odkaz: https://doaj.org/article/233fc8102f9c4f019ed65089bafe6307

Genome sequence of Rhizomucor pusillus FCH 5.7, a thermophilic zygomycete involved in plant biomass degradation harbouring putative GH9 endoglucanases

Autor: Silvia Hüttner, Zoraide Granchi, Thanh Thuy Nguyen, Sake van Pelt, Johan Larsbrink, Vu Nguyen Thanh, Lisbeth Olsson

Publikováno v: Biotechnology Reports, Vol 20, Iss , Pp - (2018)

We report here the annotated draft genome sequence of the thermophilic zygomycete Rhizomucor pusillus strain FCH 5.7, isolated from compost soil in Vietnam. The genome assembly contains 25.59 Mb with an overall GC content of 44.95%, and comprises 10,

Externí odkaz: https://doaj.org/article/5bdd8918156647c3a89b885da4be1952

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles

Autor: Kristina Hettne, Wouter N. Leonhard, Leo S. Price, Hester Bange, Peter A C 't Hoen, Tareq B. Malas, Dorien J.M. Peters, Zoraide Granchi, Gerard J. P. van Westen

Publikováno v: EBioMedicine
Ebiomedicine, 51
EBioMedicine, Vol 51, Iss, Pp-(2020)
EBioMedicine, 51, 102585
EBioMedicine, 51. ELSEVIER

Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common causes of end-stage renal failure, caused by mutations in PKD1 or PKD2 genes. Tolvaptan, the only drug approved for ADPKD treatment, results in serious side-ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d901869cbb1ae0301ec51281fa4381a6
https://doi.org/10.1016/j.ebiom.2019.11.046

Draft Genome Sequence of the Basidiomycete White-Rot Fungus Phlebia centrifuga

Autor: Steven R. Ahrendt, Zoraide Granchi, Thomas Chin-A-Woeng, Igor V. Grigoriev, Matthieu Hainaut, Mao Peng, Bernard Henrissat, Robert Riley, Sake van Pelt, Ronald P. de Vries, Kristiina Hildén, Rosa Hegi, Miia R. Mäkelä

Publikováno v: Genome Announcements
Genome Announcements, American Society for Microbiology, 2018, 6 (14), pp.1414-1431. ⟨10.1128/genomeA.01414-17⟩
Genome Announcements, 2018, 6 (14), pp.1414-1431. ⟨10.1128/genomeA.01414-17⟩
Microbiology Resource Announcements 14 (6), 1-2. (2018)
Microbiology Resource Announcements, 6(14). American Society for Microbiology

Here, we report the genome sequence of wood-decaying white-rot fungus Phlebia centrifuga strain FBCC195, isolated from Norway spruce ( Picea abies ) in Finnish Lapland. The 34.66-Mb genome containing 13,785 gene models is similar to the genome length

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284769c96ca5a8e3eb1d35175a3d728b
https://hal-amu.archives-ouvertes.fr/hal-02094600/file/e01414-17.full.pdf

Combined genome and transcriptome sequencing to investigate the plant cell wall degrading enzyme system in the thermophilic fungus Malbranchea cinnamomea

Autor: Thanh Thuy Nguyen, Lisbeth Olsson, Vu Nguyen Thanh, Dag Ahrén, Thomas Chin-A-Woeng, Johan Larsbrink, Zoraide Granchi, Silvia Hüttner

Publikováno v: Biotechnology for Biofuels
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-16 (2017)

Background Genome and transcriptome sequencing has greatly facilitated the understanding of biomass-degrading mechanisms in a number of fungal species. The information obtained enables the investigation and discovery of genes encoding proteins involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54a59c35b81416b92ff647cd8d0b540
https://doi.org/10.1186/s13068-017-0956-0