Výsledky vyhledávání - "Zoraida Diaz"

Akademický článek

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

Autor: Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A. Casero, R. Grace Zhai

Publikováno v: Cell Death and Disease, Vol 15, Iss 5, Pp 1-10 (2024)

Abstract Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy

Externí odkaz: https://doaj.org/article/df16f6f1f6604cb3868b67740e22aee2

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Akademický článek

Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells

Autor: Xianzun Tao, Yi Zhu, Zoraida Diaz-Perez, Seok-Ho Yu, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero Jr., Richard Steet, R. Grace Zhai

Publikováno v: JCI Insight, Vol 7, Iss 13 (2022)

Polyamine dysregulation plays key roles in a broad range of human diseases from cancer to neurodegeneration. Snyder-Robinson syndrome (SRS) is the first known genetic disorder of the polyamine pathway, caused by X-linked recessive loss-of-function mu

Externí odkaz: https://doaj.org/article/a6c751f5d2ab41d29f14f66b38a91469

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Akademický článek

NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

Autor: Jiaqi Liu, Xianzun Tao, Yi Zhu, Chong Li, Kai Ruan, Zoraida Diaz-Perez, Priyamvada Rai, Hongbo Wang, R Grace Zhai

Publikováno v: eLife, Vol 10 (2021)

Gliomas are highly malignant brain tumors with poor prognosis and short survival. NAD+ has been shown to impact multiple processes that are dysregulated in cancer; however, anti-cancer therapies targeting NAD+ synthesis have had limited success due t

Externí odkaz: https://doaj.org/article/583ee0b6603f436bb75eba4397cd08fb

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Akademický článek

Trypanosoma cruzi loop-mediated isothermal amplification (Trypanosoma cruzi Loopamp) kit for detection of congenital, acute and Chagas disease reactivation.

Autor: Susana A Besuschio, Albert Picado, Arturo Muñoz-Calderón, Diana P Wehrendt, Marisa Fernández, Alejandro Benatar, Zoraida Diaz-Bello, Cecilia Irurtia, Israel Cruz, Joseph M Ndung'u, María L Cafferata, Graciela Montenegro, Sergio Sosa Estani, Raúl H Lucero, Belkisyole Alarcón de Noya, Silvia A Longhi, Alejandro G Schijman

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008402 (2020)

A Trypanosoma cruzi Loopamp kit was recently developed as a ready-to-use diagnostic method requiring minimal laboratory facilities. We evaluated its diagnostic accuracy for detection of acute Chagas disease (CD) in different epidemiological and clini

Externí odkaz: https://doaj.org/article/957c41d6cf8341b38112db105e8a2f81

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Akademický článek

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Autor: Chong Li, Jennifer M. Brazill, Sha Liu, Christofer Bello, Yi Zhu, Marie Morimoto, Lauren Cascio, Rini Pauly, Zoraida Diaz-Perez, May Christine V. Malicdan, Hongbo Wang, Luigi Boccuto, Charles E. Schwartz, William A. Gahl, Cornelius F. Boerkoel, R. Grace Zhai

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Mutations in spermine synthase lead to Snyder-Robinson syndrome, a form of intellectual disability syndrome. Here the authors develop a Drosophila model of this disease, and show that lysosomal dysfunction and oxidative stress contribute to the morph

Externí odkaz: https://doaj.org/article/5308d37db71b41d29e24ce8ca83bcc96

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Akademický článek

Exposure to Aerosolized Algal Toxins in South Florida Increases Short- and Long-Term Health Risk in Drosophila Model of Aging

Autor: Jiaming Hu, Jiaqi Liu, Yi Zhu, Zoraida Diaz-Perez, Michael Sheridan, Haley Royer, Raymond Leibensperger, Daniela Maizel, Larry Brand, Kimberly J. Popendorf, Cassandra J. Gaston, R. Grace Zhai

Publikováno v: Toxins, Vol 12, Iss 12, p 787 (2020)

Harmful algal blooms (HABs) are a rising health and environmental concern in the United States, particularly in South Florida. Skin contact and the ingestion of contaminated water or fish and other seafood have been proven to have severe toxicity to

Externí odkaz: https://doaj.org/article/eb3342f05e144c5e97f6dd255b96cf5a

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Akademický článek

Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The originally published version of this Article contained errors in Figure 1. In panel c, the grey shading denoting evolutionary conservation and the arrowheads indicating amino acids affected in Snyder-Robinson syndrome were displaced relative to t

Externí odkaz: https://doaj.org/article/e8956b7df6b54d48be6047c1abdfabb6

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Akademický článek

Analytical performance of a multiplex Real-Time PCR assay using TaqMan probes for quantification of Trypanosoma cruzi satellite DNA in blood samples.

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 1, p e2000 (2013)

BACKGROUND: The analytical validation of sensitive, accurate and standardized Real-Time PCR methods for Trypanosoma cruzi quantification is crucial to provide a reliable laboratory tool for diagnosis of recent infections as well as for monitoring tre

Externí odkaz: https://doaj.org/article/349310f3589b4050947ab76a6fc836e7

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